11: Breaking the Cycle: Biotoxin Removal and Healing CIRS
27 Jan 2025 · 32 min
Two clinicians discuss the Shoemaker protocol for treating chronic inflammatory response syndrome, starting with identifying and removing biotoxin exposures. Cholestyramine is the gold standard binder to block recirculation. MARCoNS, a resistant sinus infection, is commonly missed and requires prolonged topical treatment with EDTA, antibiotics, and other agents.
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And so you, you feel this graded, sometimes precipitous improvement in all the manifestations that you should expect. If your mitochondria are healing, if your brain is repairing and your immune system is balancing, think about the global state of those three things. If your brain's on fire and that's put out, and then from those ashes you're building new brain tissue, because that's truly what VIP can do.
Foreign. Welcome back, everybody. We're going to talk about all things chronic inflammatory response syndrome. Just as a reminder, this is all based on a blog series that we have on maternal grade functional medicine that kind of walks through these. So we're going to kind of keep going forward, talking through step by step by step and say we're talking about the serious treatment protocol. And so the first thing is to ask ourselves today, you know, most people familiar with Richie Shoemaker, his work, the shoemaker protocol. So, Dr. Jensky, you know, what is the Shoemaker protocol and how does it address the fundamental issue of chronic inflammatory.
So it's the protocol that was designed by Dr. Shoemaker to essentially identify the source of exposure and ultimately work your way up in a stepwise fashion through removing that exposure and correcting any of the underlying abnormalities. And so to be more specific, it's shaped like a pyramid and at the base of the pyramid it's what's my exposure or exposures and what am I going to do about it? And then as you work up, you're correcting these abnormalities and or biomarkers that we're seeing related to SIRS protocols. And so is there immune dysregulation, are there gliadin antibodies, are there issues with hormones and inflammation, et cetera. And all along the way, the whole point is to remove the toxins, detoxify that patient, decrease inflammation, try to balance the system best you can, get it as close to the finish line as possible, and then when able to do so, get them on vip, which is a neuropeptide nasal spray that reverses sirs, turns off the dysregulated transcription, turns the mitochondria back on, and in essence essentially reverses sirs. So the shortest version is it's the way to treat a CSRS patient from bottom up. And really it hasn't been modified much since it was first put out there. I mean, Andrew Heyman has taken it and kind of made it a little bit more mainstream and added some more nutraceuticals and natural treatment options that we can use for some of these steps. But the steps remain the same. And the most important step, which is step one is identify the source of the exposure and remove the patient from it or help them detoxify it some way. So can you speak to that about sources of exposure and the importance of these, the removal of these biotoxins?
Well, the thing about, you know, a lot of people want to get better but not treat the source. And so part of what functional medicine is, what we do is identifying triggers or removing them. And if you have a trigger for your innate immune system, being dysregulated, being overactive, and if you don't remove it, it's still gonna tickle, tickle your immune system. And ultimately this is kind of like an adjuvant type response, which is like how vaccines kind of work. That's how your native immune system kind of works. You had these foreign things, your body chews it up, you know, it presents its immune system. And what happens with this, it's staying on one side of that spectrum. It can bleed over or pop over to the antibodies, but usually it's stuck, some stuck on that one side. And so what can happen is it just, you get this low grade inflammation, but it's not the standard inflammation of like regular blood markers. It's in your native immune system. So hence person goes to the doctor, they get labs tested, they're all normal. There's nothing wrong with you because they're not looking at their innate immune system. And so you really do have to remove the exposure. And that's the reason why sometimes you can remove the exposure. But if the person has stored up so many of these, these toxins in their fat cells and their cell membranes, then they can feel a little better, you know, but unless you really actively detoxify those with binders, lipid medicine, you know, all the kind of things that we've talked about before, then you don't necessarily lower that activation of your immune system. The immunization immune system can still stay dysregulated. Like you get a vaccine the first time you get it, immune system reacts, second time, it reacts more robust, third time, more robust. So what can happen with these people is as they've been exposed, they remove it, but now their body's primed, they get a, they get an exposure and they have a more robust response. So really, you know, you need to remove the exposure to do the, it's the first step of the treatment protocol. Makes sense. Yeah. But also gives you body breathing room to start the healing process.
Yeah, I mean it's, it's so important because it's really the key is that these individuals don't have the ability to clear these toxins. So it's not that the exposure in and of itself is a problem, but it's the exposure and the fact that they stockpile them. So the way I explain it to my patients is we're all born with a toxin bucket. And in your case, you get exposed and your bucket fills up a little bit and you leave and you take those toxins with you, whereas someone else might empty them out and come back with an empty bucket and have more room to fill. You come back with that bucket that's partially filled and you take on more toxins and you leave. You take those with you. And over time, that bucket's filling up. And over time you're feeling the effects of that clinically and we're seeing that in objective data. You're more inflamed, you're more immune dysregulated, you're more mitochondrially impaired, and that's a problem. So to, to not let this sinking ship sink. Right, you want to patch the holes, but ultimately you gotta get that, that exposure sorted out. And the next step is the binders, as you alluded to. So the, the old gold standard is cholestyramine. And, and why is that such an important binder? What are the effects of cholestyramine? What's that doing essentially for an individual?
Well, the thing that's unique about these mold, like the biotoxins associated with chronic inflammatory response syndrome, is that they have, they both, they're kind of this weird, amphipathic is a fancy term. They're both water soluble and fat soluble, which means they can literally cross right through cell membranes. And one of the ways you should buy detoxifies these, these types of toxins is putting in bile and you poop it out. Well, the problem with these is because they have that ability, they can kind of just go right back in your system. Yeah. And so what happens is your body just recycles it. You like, your body tries to get it out, it gets dumped in your stool, your colon, and it comes right back in. So, and people who have the genes for this are especially susceptible to that aspect of it. So binders are kind of like cutting that whole process off. These bile acid sequestrants, they're called, they actually specifically bond on the bile. And so what happens is these particular type of molecules, they will specifically bind to them, prevent that recycling and you proof it out. So it's literally for people who have this gene, this deficit is like let me help you with this. And it's actually they work really, really quite well. Cold Star mean being the, the very first one. Now we're using more well call these.
Days because nobody likes the chunky orange powder.
No one likes it, people hate it, it comes with a nasty flavor and they get the light work. It does work. Yeah, it works great. But so we're using more well call which is you know, about half as effective, you know as Cold Star if I remember that correctly. Works well but just not as good as cold staring. But if you don't take it, it doesn't matter how well it works.
Yeah.
And you can also take as a pill but the versus why don't you explain this Dr. Jensky? Dr. Jensky. Yeah, so we talked about these two. There's all these other binders, you know, activate charcoal and claim a bunch of other things like how, how is is cold starmin and well call. How are they different than charcoal? Clay, alginate. Yeah, Zeolite.
All these other that are often told to patients are also biotoxin binders which is not true and that's, that's one of the misconceptions. So as you mentioned, they're bio sequestrant acids. So basically they're used for lipid lowering. Right. They're, they're anti cholesterol drugs and they were kind of used for that reason and are still used for that reason for people that, that don't tolerate others or choose to not tolerate others. And then there's that off label used for secretory diarrhea which is how shoemaker kind of fell into all this. Everybody was pooping their pants and so they got cold styrene and their headaches went away and their autoimmunity reversed and their joint pain got better. And he was like, well there's something to this. So basically the way I explain it to patients is it's kind of like a pitcher and a catcher. Your liver is the pitcher, to use a baseball analogy. And the cholestyramine or the cholecevalam AKA Walcol is the catcher. Otherwise you get that enterohepatic recirculation that you were describing. So there's a polarity that develops and like a magnet, negative, positive, it claps together and then you poop it out, assuming you're pooping. Side effect of these medicines, constipation. So you gotta make sure the patient's gut's working. And so in that case it's binding. Truly the inflammagens that are associated, these inflammatory mediators created by innate immune activation. And in essence, indirectly that means it's pulling toxins out as well. Whereas something like clay or charcoal or zeolite, they are not the same. They are more adsorbent or doing something different or porous in a way that they are maybe effectively detoxifying that patient for other reasons. Environmental pollutants and things of that nature. Biological metabolic byproducts. But they are not biotoxin inflammation binders per se. Charcoal zeolite clinic. They're not gonna do the same thing that these binders will do in patients. They're not gonna have the same outcome. And so that's a little bit misleading. Cause there's a lot of patients that believe that they're the same same same. And that's not true. There is, however, a natural B version. There's a good study that showed that okra and beet extract actually can help to have the same mechanism of action and binding. Much weaker, but natural and more tolerable by people that are very sensitive as the cholestaramine and colacevolam. And there are a couple of decent brands on the, on the market that do that. So I have utility for all those things in these patients because they, they're not just biotoxic, they're just toxic. And so you have to get them on the right binders. But you can use those other binders too and maybe use those other binders to decongest the system as a whole, allow their liver to be less stagnated and then they can tolerate the prescriptive binders for iotoxin specific later on. But it's not same same. And I think that's a little bit misleading.
There's a couple new nuances of that. You know, the okra and this was the same article that they pulled Schumacher and Heyman pulled up. It worked. It has about 20 to 25% of the binding capacity. Yeah. So it's. It's much weaker. Yeah, weaker, but it works. Yeah. The other thing I think is interesting with well call and cold Stein is they also REM solvents. There's actually great literature because of their fat soluble. And there's similar diseases like Asia syndrome, which is an adjuvant related. Yeah, but part of that is actually adjuvant. The original adjuvants were fru adjuvant which was, you know, being primarily from our studies. The original vaccines actually use petroleum distillates, acid juvent before they advance to things like metals and things and so in our environment, petroleum exposure, petroleum distillates, car gas, diesel gas, can actually, if you're exposed like an airline pilot, there's a thing called aerotoxic syndrome can have a similar inflammatory kind of responses. So that the cool thing about the bile acid like the cold stymine and wall call is they can actually get that stuff out of your body. The new, the unique thing about activated charcoal, which I find personally really fascinating, is it two things it does. One, it actually increases your cloth gene activity, which is a new buzzword right now. Yeah.
Longevity gene.
Yeah, it was kind of cool. And it actually binds into toxins which some of our patients. And this is one of the nuances with know chronic inflammatory response. And part of that is endotoxins.
Right.
From the environment.
Polysaccharides.
Yeah. Which is a big trigger for chronic inflammatory response syndrome. So maybe some of these people have really great responses with some of those binders because they have you treat your gut and you're getting that endotoxin which. Yeah. So it's kind of. It's cool to know all those things because then when the patient comes in, you have here the store and you're like trying to put the pieces like hey, that worked. That didn't work. That worked. And you're trying to figure out, okay, is this the building? Is it your SIBO gut issues?
Is it? And you can measure, right. You can do a SIBO test, you can do a stool analysis, you can do a Swiffer test that measures endotoxins in their home. And so if you're correlating a home environmental endotoxin exposure or you get SIBO positive or they're growing gram negative bacteria in their gut.
Yeah.
You know those make lipopolysaccharide. Then you might layer in some charcoal. I mean that's the beauty of all this is you have these tools. Talk about Marcons a little bit. What the heck is that?
It really amazes me how many people who go to mold people don't test and treat for Markovs. It's so Markons is it's really important like in the other the triangle. If you go to the website, it's.
The bane of my existence.
It's the bane of. Yeah, yeah. So but it's important part. Yes it is. But it's multidrug resistant Staphylococcus aurus that releases hemolysins which are chemicals that actually affect MSH production in your brain. They actually the POM C molecule, which is the same molecule, it turns into that makes cortisol. CRH also affects alpha MSH melatonin. It's like a really, really important molecule and the toxin made by this thing in your sinuses actually messes all that stuff up. It can increase people with pain syndromes, chronic fatigue and fibro. It can affect your sleep quality. It affects some of the downward inhibition. Like the shoemaker talks about the regulation, regulation, regulation. Part of that thoughts coming from midbrain. It's actually affecting that via nsh. And so if you don't test it and treat it that can actually keep your MSH suppressed which ultimately affects your natural killer cell count, your immune system. The natural killer cell count is downstream innate stuff upstream is more like MSH kind of stuff. And so it, it makes it hard for your body to heal. And I've had patients you probably have as well who do binder treat the mark comms and all of a sudden they're like oh my gosh, I feel so much better after this. It is the beginning of your existence because it's always positive tends to come back. Yeah, it took a long time.
It takes a long time to treat. It also affects gut right? So tight tight junction dysfunction which could potentiate or spark off autoimmunity in someone. It affects androgen levels suppressing those. So I think about something that's going to cause you to be more tired, cause you to have more pain, cause you to sleep poorly. Hormones suppress your your testosterone and your guts off. Like that's probably important. And there it is. And really the reality is you get the biotoxin exposure. MSH comes down as part of that pathway and now you're susceptible to colonization of Marcons which suppresses it even more. And now you're in a chase youe tail phenomenon. So I don't know how you don't diagnose and treat it. The problem is treating it. So how do you go about treating it?
You know there's been a lot of variations and originally using beg which was bacitracin, EDTA and gentamicin and I'm, I.
Still use that a little bit. I'm concerned about the ototoxicity but I always disclaim to patients.
I said one patient lose hearing from it.
So I have a couple that that have said you know what, I got a lotonitis so I'm gonna stop it. The rest do fine on it. And I use it very sparingly in like I've been on EDTA for six months and it's still not going away. What are you doing differently. And if it's sensitive to gentamicin, which you can see on these Marcons, swab results. Right. You see sensitivities, you see resistance patterns, then I might use it.
Yeah. So then we kind of.
With consent, obviously.
Of course. Yes, of course. Informed consent of.
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And so then we kind of moved to more using a combination of EDTA and Coital Silver, and then using more. Now we're using more just plain edta, which is a biofilm buster. I tend to use that add on Coital Silver to it because as you see alluded to, it's just really hard to clear people. You know, the technical protocol, which is one of the sticking points is you do this for six weeks and then retest them. And I stopped doing that early on because I realized it's taken three, six, nine months sometimes for people to clear first. This is anecdotal toy, but personally, I actually cleared mine Marcons with Betadine. I just switched out the coil silver one metal with another metal. And using any pot.
Yeah.
Was actually able.
I can't use an edipod. It checks me out.
There's a new one, actually nowhere in Greece that Becky introduced me to is my wife.
Yeah.
And it's actually, it's. It's almost like a. Like a gravity fed that he bought.
Oh, cool.
And so what happens is it takes the water, it puts in a column up. So it gives you a little bit of gravity. Yeah. So it gives you a little bit of pressure, not too much. And you push the button on top and.
Yeah. Goes through my patients do that and they use biocide and liquid. I have them do that sometimes. I've had heard patients sit on their own using some iodine.
There's a new thing in one of my patients. Right. Told me about because she called the people from Micro Biodx and they're recommending. Because some of their. They, the people do the culturing using ACS supreme or. Yes, it's a silver. It's just. It's coil silver. But they also have echinacea, a couple herbs in there.
Yeah.
So.
So X layer, which is xylitol as a biotin buster that you can use and that sometimes has grapefruit seed extract in it. Some other things I think they make one with echinacea and then citri drops, which is homeopathic but very effective and was designed by an ENT in Georgia who treats a lot of mark on the new citri drops. All that Citri drops, okay. It's microbiologicalformulas.com they always run out and then they restock and then they run out. Nasal spray. Nasal spray, yeah. It's basically homeopathic citrus antifungal antimicrobial has some biofilm disruption. I have some patients that are intolerant of the edta even when I go really low strength that they do well on the citri drop. So you gotta. It's a crapshoot. You gotta use a lot of different stuff.
So what I'm hearing is we're willing to try whatever. Yeah, you gotta get it go away, you gotta get going. Fair enough.
And the. And most importantly, if they have an ongoing exposure, they're probably not going to eradicate the mark ons. So get the exposure. Right. Because that might be the issue.
So we're back to step one.
Right. That's why it's step one. Get the exposure right. Then maybe reassess the mark ons. And sometimes in rare situations the patient might have a root canal gone wrong and a cavitation that's harboring the bacteria. And that needs to be addressed. And so that's. Sometimes that's a possibility.
So part of the Schumacher protocol is actually eliminating getting your anti gland antibody down, which is related to like wheat gluten kind of stuff. Why don't you talk about that a little bit? Because it's not celiac disease, but you have to remove gluten. So why don't you walk us through that? Because. Because that's an important part of the.
Yeah. So I mean really all my service patients are gluten free for that. I measure the gliadin antibodies. Even if they're negative, I just say don't eat gluten, your gut's already leaky. Cause we talked about how suppressed MSH is gonna do that. I essentially tell em your tight junctions won't work until you're outta service. Even though you're doing all the right stuff. We can get em better. It won't get across the finish line. The last thing you want is something that's gonna propagate, potentiate that. And we know gliadin does that. It's the protein from gluten. And when you see these antibodies, it's a conversion that's presenting like non celiac gluten sensitivity and therefore like celiac, although not autoimmune. It's the cure is avoidance. And so strict avoids the gluten and cross contamination so that their gut can heal and calm down. Because the last thing you want is potentiate that to the point now that if they have the gene that now you're triggering something like celiac to fire off. So I just know this patient's gluten free.
The thing about, about gluten, everybody gets a little bit of leaky gut with gluten immediately. So it's one of those things if you've already got gut issues. MSH is already low. Yeah. Which you're propagating that a little more than eating it is just going to make your healing process. You know and really, you know, step one and you know, and healing is remove. If there's something stopping your body's natural healing process, remove it. Yeah. If your body's lacking something, give it to your body.
Yeah.
And your body has a natural, this amazing ability to self heal and self repair.
Yeah.
But the first step is going to be remove that thing that's blocking your body from healing. So.
Yeah. And then you know, I'm going to leapfrog a question about androgens and hormone imbalances. I mean I feel like we can talk about hormones all day and, and that's something we can touch on. I want you to touch on the ADH osmolality dysfunction that we see because I know that you speak on a lot of our social media channels and have done blogs on, on dysautonomia and knots and, and I consider you to be one of the leading experts in this area on this. And so I'd like your thoughts on kind of some of the ADH osmolality stuff that you're seeing and how this Is a little bit unique in how it affects almost a POTS like or dysautonomic picture that in this case is potentially reversible, which is pretty amazing.
Yeah. So the ADHD osmolalti. What happens is because of that dysregulation, again, the regulatory part of your brain, you know, adh, cortisol, those are the regulatory centers. That's also where your other hormones get regulated, become dysregulated. So one of the effects is that your body has a hard time keeping recycling water, basically. And so the phenomenon is people drink water like, I'm drinking water, I'm thirsty, but just come, I just pee right out. It's really an interesting phenomenon because one of the effects of that is you actually, you get, you know, hype. You actually get hypovolemic. You actually, your white volume actually goes down and the cells actually become dehydrated. And one of the effects is, is actually the sodium chloride, the salt in your skin goes up a little bit. So it's really a bizarre phenomena that people actually conduct stack electricity more. So one of the questions you ask people when we do the intake, you know, the cluster analysis is do you get shocks? And it's really bizarre how the ADH osmolality can actually affect how. How well you hold and create stock electricity. So much so that during the wintertime around here, people be like, oh, yes, I shock everything. I never thought about that.
Right.
No one ever does. Yeah, yeah. And sometimes, sometimes it will be to the extent that people actually will mess up electronic equipment. And so in that. So walking back, that ultimately is our bias inability. You're actually developing of type of dehydration and you drink water which dilutes out your electrolytes and it gets even worse. And so what can happen is you get this pots like phenomena. There's three types of dysautonomia. Right. I'm sorry, three types of pots. You know, one's autoimmune, one's neurogenic, and then one is neurogenic, autoimmune and adrenal. And so what happens is, is this one doesn't. It looks like that, but it doesn't fit the same kind of paradigm. People can still get better if you do the electrolytes. Right. Which is helpful and you do the fluids. But you really need to address the whole mold kind of thing. Yeah. What can happen, however, is this is one of the neat things I've discovered is there's this. Well, I haven't discovered this part. This is part of Just in one of the weird worlds that we kind of live in, there's this thing called the Pentad super syndrome, which is hypermobility, dysautonomia, GI dysfunction, autoimmunity, and mass activation. Thanks for that. So, so when you see one of Those, and then 6 and 7 are cranial cervical instability, there's a bunch of other things outside that. So. But one of the things that sets people off, this is hypermobility, which about 20% of our population is hypermobile. So all of a sudden, someone's in a multi building, they start developing pots and dysautonomia. Go to the pots experts and they're like, let's do IV fluids, let's do 80, let's do Adderall for your brain fog, let's do midrine to get your blood pressure up, whatever. And the triggering event is actually mold.
Yeah.
And so all of a sudden, when I see these dysautonomic patients and we've learned from the pandemic, you can actually have the COVID vaccine, can be a trigger for dysautonomia. So can Covid. We've known about that for, from other viruses. People get like the flu and they get dysautonomia, get concussion, gets dysautonomia. Concussions are one of the peripheral serious phenomena. Right. There's like the 80% total damage building, then 20% and that 20% concussions, head injuries are on this. So all of a sudden now we're seeing links between like what we thought were standalones, dysautonomia pots, and they're not, they're linked. And so now when someone comes in and they have dysautonomia pots, I'm like, okay, stepping back. Is mold at play here? Since half of all buildings have water damage.
Right.
Or any other, these serous phenomena, which include endotoxins, and that's where you're getting some of the gut stuff. And with dysautonomia, there's an interesting case in Texas that had a patient cured with pots and they did ivigg, low dose naltrexone, which we use a fair amount of. They treat sibo. In my mind, that's all still okay. You know, gut stuff, endotoxins, immune dysregulation, TH TH12 with the lenos, naltrexone, then Ibigg's immune modulation. All of a sudden that's. With that. Okay. All of a sudden. Now how can we track those dots for some of our patients? So. So The ADH osmol. I think it's intriguing. I did do some. Some patients try nasal. Yeah, nasal's helpful. But ultimately it's like you really. To get that, you know, I will do one thing. This is not part of the Shoemaker protocol. For those people, I will give them cell salts. I'll do potassium citrate, magnesium citrate with trace minerals. I would. I'll try to al alkalinize the urine, which helps improve the redox potential with. And that's all put into the fluids it should be drinking. You know, 1 ounce per kilogram of body weight of fluids at least. And if they need extra sodium, I found out with. That actually is more benef. Can be just as beneficial as people who do all the salt pills and stuff. That by itself can actually help improve some of their cell redox cell function. While you're like eliminating the mold and treating the Marcons and doing the binder. And it gives people a extra kick in the butt, which. It's cool.
Instead of being idle and being so symptomatic. I mean, I've had patients come in with POTS diagnoses. I've had two to date, and that doesn't seem like a lot, but when you come in having seen a POTS expert who are rare, and you're seen as a fringe patient, and you're on all these weird beds and you can't walk around the block without passing out or almost passing out, and then you get through Shoemaker protocol to VIP and reverse serves and you're off your meds and you write me a portal message saying, I just hiked the Blue Ridge Mountains, I would consider that a cool cure. And I've had two cases like that, so that's really cool. And so I think that until, you know, you don't know what the underlying etiology of what your condition might be. And a lot of times biotoxins are the answer, and I think that's a big deal. All right, what else?
I don't. You want me to touch on the.
Hormone stuff a little bit?
I mean, really, I think that's probably. That's not on the question list here, but I think talk about that because it's. It's an important part. Um, I'm not sure we want to dive into VEGF too much.
And then, I mean, the VEGF and the MMP9, just briefly, are just kind of the. Some of the. The biomarkers that we're using to make a case report, and eventually they're going to correct over Time. Now, if they're abnormal and they're progressively getting worse, you probably need to intervene. That might be a little bit beyond the scope of what we're trying to, to do at this point in time. But, but with regards to hormones, I mean, I feel like everybody kind of has a hormone problem. And, and we're talking about in this case things like sex hormones, that we see these abnormalities in particular androgens. And so that's the global term for what we would say is male sex hormones. So testosterone and things of like that nature. So we see them suppressed. And so how many times do you see in your practice an NF backed into a source diagnosis this way, a metabolic patient who has, you know, a little bit of hypertension, a little bit of that spare tire, their testosterone's low. And you're just assuming this is because this person's not eating right and they're not exercising or stressed out and their hormonal pyramid is off and now he's got to work on X, Y and Z. And it turns out that they're a biotoxin patient. And I've, I've had that happen a couple of times. And really the reality is, is that that testosterone can kind of autocorrect as you work your way out of the system. But you can benefit them by doing the low hanging fruit, which for me is making sure they're getting adequate protein, making sure they're getting some resistance training, getting adequate zinc, managing their stress, optimizing their thyroid function. And then do you want to do some things that might boost their thyroid or their testosterone naturally? I like libido stem or tea time or something along those lines. But in a younger male, you might consider something like clomiphene or enclomiphene. And in an older male or younger who doesn't want to have children, you can even do testosterone replacement. But that's really not anything I would do. Early in the course of this treatment, you want to really start with the biotoxic stuff because you really see a lot of auto correction along that way. And so the process is really about going in that stepwise fashion. And you can see this improve as MSH comes up, as that ACTH cortisol loop starts to balance out, as their gut starts to heal, as their nutrition starts to improve, and you just kind of see that kind of.
No, the way I want to end, I want, the last thing I want to talk about is the tip of vip, you know, and you've fluted, you've said a one ton much VIP in the past, how it resets the genes in the brain and how it's like amazing, it's dicing on the cake. And, um, I don't want to talk about that stuff, but I want you to tell us like your experience with using it. Yeah. And what you've seen with the use of Vip, because that's. I think people talk about all the, the fancy stuff, but like, you know, seeing it actually with.
Yeah, I've used it. So. And it's not because I was experiment three, it is because I had cers. Yeah. So it was a game changer for me. I mean, the main reason I came to see you is because my brain stopped working and. And I had all the things that I essentially were just attributing to poor lifestyle choices and getting older. And the reality was when my brain was basically broken is I said, something's not right. And you said, yeah, you're moldy. And I was like, okay, what does that mean? And I got the little lecture and hence, here we are. And so as I got on Vip is when I really realized the true nature of the extent of what was going on in my body. Because it was for the first time in probably, I want to say 15 years that I felt switched on. It was literally akin to a light switch. I woke up and I felt like my brain's working again. I'm thinking more clearly. There's my memory, there's my recall, there's my ability to learn, there's my energy. And so you feel this graded, sometimes precipitous improvement in all the manifestations that you should expect. If your mitochondria are healing, if your brain is repairing and your immune system is balancing, think about the global state of those three things. If your brain's on fire and that's put out, and then from those ashes you're building new brain tissue, because that's truly what VIP can do. If you have dendritic pruning, that isn't irreversible brain damage. VIP is repairing it. And the volume loss becomes volume expansion and normalization. I took a brain damaged patient and brought them back to normal. I don't know of anything else that can do that. If your mitochondria don't work, you don't work. Period. Hard style. It's not just the power plant in the cell. It is the sensor. It's the canary. It's the canary of our cell. Sensing internal environment, sensing external environment and then informing the cell. This is what we should be doing in the case of a biotoxin exposure. That information is, doc, get into battleship mode. We are in a cell danger response. And when you're out of that and VIPs turn them back on and they're cloning out, you get mitochondrial biogenesis. All of a sudden, that signal is, let's make energy party time. Right. You feel switched on. So I just remember feeling like I got myself back. I remember feeling like this is who I knew myself to be when I. You know that moment when you ask patients, when was the last time you felt well. And everyone kind of hates that question, but it's an important question because an establishment of a timeline, it tells you when things might have really gone wrong. Building up to that point, when you get on Vip and you reverse your surge, you get back to that, this is when I last felt well. But then you build upon that and you actually feel even better. So for me, it was akin to a light switch. It was transformative. It gave me my life back, it gave me my brain back, it gave me my health back. And it gave me the realization that what I was suffering from was something that was correctable and not this sentence that you're often told you have by conventional medicine, sorry, that's your lot in life. Sorry, that's genetic. Sorry, that's idiopathic. Not okay. I wasn't okay with it and we fixed it. And I mean, that's really my thought on vip.
Cool. Gotcha. So that's a walk through the Shinika Protocol.
Yeah.
Going through it piece by piece by piece. Hopefully that was helpful. Again, refer back to the blog series on this. And next we're going to talk about the appendix, which is a potpourri of some things. Hopefully we can get into some other kind of topics as well. Goals here by a really well rounded understanding of chronic inflammatory response syndrome. So they can be the healthiest version of them that they can be.
Yeah.
All right, take care.
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