28: The 400-Year-Old Therapy That’s Healing Brains – HBOT Explained with Dr. Aaron Hartman
20 Nov 2025 · 4 min
Dr. Aaron Hartman explains hyperbaric oxygen therapy, a 400-year-old treatment that pressurizes oxygen to boost mitochondrial function and increase stem cells up to 800%. FDA-approved for wounds and infections, it's used off-label for brain injuries, stroke, and autism. He recommends five dives weekly at $150-250 each, typically 20-40 sessions for concussion or up to 80 for stroke.
Questions this episode answers
April 25, 2025
Five days per week (sequential daily dives).
Chronic issues: ~1.5–1.75 atmospheres; acute stroke/TBI/concussion: closer to 2.0 atmospheres; soft chambers: ~1.3 atm; an animal-model low-pressure result cited at ~1.08 atm.
About 8,000 genes.
Up to ~800% increase in stem cells.
Chapters
You want to get the benefit of the hyperbaric timing. You have to do it five days a week. If you do it one day a week, the effect on mitochondrial efficiency and stem cell stuff that stacks and builds, you need to do it sequentially to get that impact. I want to talk about something briefly that I've been asked about that really is in many ways a cutting edge therapy that's been around for 400 years. And what is the cutting edge therapy that I'm talking about this program for 400 years? It's hyperbaric oxygen therapy known as HBOT. HBOT. I was actually first using the 16 came in the United States when the Brooklyn Bridge was being made. If you remember Caseon's disease, people actually getting the bends basically from going deep down and digging out the footings for the bridge and the, from the compression chambers. And in the 20s they actually had this big compression chamber. It was like a resort people were going to. But when World War II came around, they tore it down, used the metal, because we had issues with metal shortage. But the point is hyperbaric oxygen therapy, it's been around for hundreds of years. This is not new. It's FDA approved to treat non healing ulcers, radiation necrosis, non healing breast flaps, flesh eating diseases. About 15 different indications. When I did my hyperbaric oxygen certification, we spent two days just learning about all this kind of stuff. It's interesting how long this has been around, yet people are scared about the. They have concerns about it. Because you like anything, if you do it the wrong way, you have problems. If you go in 100% oxygen chamber and you don't have 100% cotton, you're not grounded. You take technology and you have a spark, it can blow up, which has happened. People died in these things before and it was pretty. That's one of the things that kind of scare me about it. But if it's one of those things, we do it the right way in the right situation, it's 100% safe. But why would you take, why would you want to do this? Why would you want to dive 1.5 to 1.7 atmospheres and 100% oxygen. There's four majors. There's a couple ways that hyperbaric oxygen therapy works. First of all, it just increases oxygen concentration. If you look at how much oxygen you have, it's about 760 millimeters of mercury of pressure in the atmosphere. About 140 of that is oxygen. So it's about 20, 20% oxygen by the time you get to your lungs that 140 becomes 100. By the time you get to your mitochondria, it's a 4 to 6 millimeters of oxygen. So this big gradient, that oxygen goes down already to get to your mitochondria. If you can jack that gradient up, all of a sudden you're going to have a lot more oxygen getting to your mitochondria and you're going to increase the efficiency of your mitochondrial function. So that's the first way hyperbaric works is by basically just improving oxy mitochondrial function. There's also about 8,000 genes that get upregulated with hyperbaric oxygen use. And you actually increase stem cells by up to 800% using hyperbaric oxygen. So all of a sudden it has a lot of cool things it can do. And also there's a seltzer effect which basically if you ever like taking open a coke at physics and you compress oxygen in tissues and it goes out once you have a tank, you have that effect in your cells. And that effect can last 46 hours after you get out of the dive. So actually hyperbaric sessions can impact for last last four hours. So it's really cool. But what can be used for. It's my go to for traumatic brain injuries, strokes, they can have impact on individuals. Actually is one of the therapies I used for my daughter to help with her brain injury that actually helped with her vision and her writing. A lot of times it's I've actually used with some of my pan as pans or autism kids because it just improves brain function. It's a brain anti inflammatory, it helps improve cellular function. Some patients who have chronic Lyme disease who can't boost their immune system up enough. If you're a patient who's hypermobile, has aches and pains, body aches and pains. Ehlers Danlos Part of that whole thing is that you have low oxygen tension in your connective tissues and if they're stretchy you have poor vascular blood flow. You can overcome that with hyperbaric and all of a sudden you can actually get oxygen to the tissues and oh by both hypermobility tend to have more Lyme because Lyme likes low blood flow tissues. And that's a bigger issue in hypermobility and all of a sudden you can overcome that. So hyperbaric has a lot of interesting uses. I'm trying to think what other questions people ask me about in regards to hyperbaric. The benefits people. Some people will mention the hard chamber versus soft chamber so this is like the deep dive versus the shallow dive. What I tell people is there's this literature looking at using 1.0, I believe 1.08 atmospheres. And these were in like an animal model for Alzheimer's showing change in brain function. So we do have data that it can blood flow even at a super low pressure. But the devil's in the details. You get the therapeutic effect, the big therapeutic effect. When you're diving 1.5 to 1.75 with 100% oxygen. If you have acute brain injury, acute stroke, acute TBI kind of thing, concussion, you do need to get closer to 2.0 atmospheres. You just need bigger pressure. For chronic issues, using 1.5, 1.75 can be helpful, but you do get a benefit with the soft chambers that go to 1.3. Again, just the devil to the details. When you do dive the 1.3, you're increasing the oxygen at the micon at the cell level. We Talked about about 400.
Ever lost trust in your own body or in the doctors who were supposed to help you heal? It happens to millions of people who are stuck in the cycle of prescriptions, tests, and more questions than answers. That's why Dr. Aaron Hartman wrote his new book Uncurable. As a physician and a parent, he's lived through the pain of being told there's nothing more we can do. But instead of accepting that, he built a new path, one that combines traditional and functional medicine to uncover what's really driving illness. Uncurable is more than a book. It's a roadmap to help you find the root causes your doctor might have missed, reactivate your body's natural healing systems, and finally believe in what's possible again. If you've lost hope or trust in the system, this book will help you take back control. Go to UncurableBook.com and grab your copy along with Dr. Hartman's free resources to help you start your healing journey today.
So it's, it's a big increase, but it's not 1600 or 1200%, which is what you get with the higher numbers. But again, if you do it daily, and that's when you probably need a tank at home. Something else people talk about is going to these tenders. Well, I'll go once a week. It's like the effects stacks. If you want to get the benefit of the hyperbaric timing, you have to do it five days a week. If you do it one day a week, the effect on mitochondrial efficiency and stem cell stuff that stacks and builds. You need to do it sequentially to get that impact. And some people just, that's, that's where it comes difficult because you have to commit to that. The other thing is price tip dives typically can cost anywhere from 150 to 250dol a dive. If you want to start 20 or 40 dives for tract brain injury, concussion kind of thing, up to 80 if you have stroke. My, my daughter's done two rounds of 40 and she does it five days a week now. She's done that for a couple years and at home 19, she continues to get better. She continues the provisions, the point. Now she's actually able to read cell phone without any problems. So there are a lot of benefits to it. But can you commit to that? And that's the problem. I think that's two big problems with hyperbaric is the commitment to the daily use of it for time and the cost. But it can be really super helpful. There are other, other ways you can kind of get similar effects depending on what's going on, whether it's peptides, whether it's central deprivation chambers, whether it's methylene, whether it's. Or light therapy. So those are all things to think about as well. Work with your practitioner, the person that you're working with, to find out if this is right for you or there's other things to try. But those are some of my thoughts about hyperbaric oxygen, its utility and how it can be beneficial to you. So if you have any additional questions, please put them below. If you have a topic you'd like to talk about, take a deep dive on. Please let us know and we'd love to just deep dive with you on a topic. Take care and we'll talk to you soon.
More from Aaron


Medical Gaslighting Doesn’t Stop in the Exam Room: How to Trust Yourself and Build the Right Care Team with Dr. Efrat LaMandre | E186


POTS and Dysautonomia: Could Nervous System Dysregulation Be Why You’re Still Sick? | E185


Best of: How Adopting a Child with Special Needs Led to a Medical Revolution | E184


Hypermobility and Fascia: Could Your Connective Tissue Be Why You’re Still Stuck? | E183


Best of: The Classroom Is Failing Our Kids – The Surprising Truth About Neurodivergent Learning with Dr. Roseann Capanna-Hodge | E182


Mast Cell Activation Syndrome: The Hidden Trigger Behind Food Reactions, Fatigue & Chronic Symptoms | E181


Best of: Are EMFs Making You Sick? – Environmental Sensitivities Explained with Dr. Neil Nathan


Could Lyme Disease Be Why You’re Still Sick? Symptoms, Testing, and What May Be Overlooked | E179


Why Your Child Is Dysregulated: Nervous System Regulation, Screen Time, and the CALMS Protocol with Dr. Roseann Capanna-Hodge | E178


Mold Exposure May Be Why You’re Still Sick: The Hidden Connection to CIRS and Chronic Inflammation


Best of: CIRS and the Bio Toxin Pathway: A Deep Dive into Detoxification and Healing with Dr. Jenski