Managing Machines vs. Managing Humans. What's The Difference? | Simon Shaolei Du, Apodex

28 Jul 2026 · 45 min
45:25

In this interview, Simon Zhu (chief scientist at Apodex) explains the company’s vision of building a "Heavy‑Duty Solver" – a large‑language‑model platform designed to tackle hard scientific, economic and engineering problems rather than just chat. He describes the first product, a deep‑research mode that emphasizes planning and problem decomposition, and how Apodex’s multi‑agent system (AgentTeam) breaks down massive tasks into many specialized agents to overcome context‑length limits. Key capabilities include sophisticated multi‑hop search (with state‑of‑the‑art performance on the BROS Comp benchmark), explicit verification agents that act as “organizers” to cross‑check results, and redundancy agents that run multiple stochastic copies of the same task to increase coverage. The conversation covers target domains such as drug discovery, finance, material science, and future prediction, and contrasts Apodex’s approach with traditional quant models and with other LLM providers (OpenAI, Claude). Zhu outlines the training pipeline (supervised fine‑tuning, reinforcement learning, expert‑annotated data), the importance of evenly distributed domain data, and the ability to ingest user‑provided data sources. He also offers career advice for graduates and engineers wishing to transition into AI research, emphasizing open‑source agent projects, referrals, and system‑level thinking. The interview ends with a recommendation to study operating‑system concepts as a mental model for building and using large‑scale agent systems.

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