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In this segment Dr. Chris Shade explains that an overload of environmental or metabolic toxins manifests as chronic fatigue and general malaise. He describes how toxins can infiltrate joints and the extracellular matrix, impair lymphatic flow, and disrupt the clearance of waste. This leads to activation of sirtuins, which triggers altered mitochondrial biogenesis, reduced mitochondrial density and function, and a shift from healthy metabolic programs to survival mode, lowering overall cellular energy. The downstream effects include cardiometabolic disturbances such as insulin resistance and fatty liver disease.

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