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In this segment of Renee Fitton's presentation, she explains how the natural decline in estrogen during perimenopause triggers a cascade of metabolic changes that lead to muscle loss, weight gain, and increased insulin resistance, contributing to higher rates of prediabetes and type 2 diabetes in people over 40‑50. She emphasizes that estrogen is crucial not only for reproductive health but also for maintaining metabolic health. Fitton then introduces fasting‑mimicking as an intervention that can improve insulin sensitivity, reduce insulin resistance, and even enable some individuals with type 2 diabetes to discontinue medication and achieve remission, highlighting its potential as a therapeutic strategy for mid‑life metabolic health.

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