Nitric Oxide: The Molecule That Reverses Fatigue, Brain Fog & Heart Disease | Dr. Nathan Bryan

Hey there, I'm Claudia von Boeselager, a former investment banker turned entrepreneur, longevity coach, biohacker, and mother of two. Once burnt out and overwhelmed with chronic health issues, I've transformed my life and helped thousands of people do the same. I've even reduced my biological age by 17 years. Yes, I'm 26 again. Now I'm here to share the tools, strategies, and inspiration to help you live healthier, happier, and longer. On this podcast, I interview world-leading experts in health, biohacking, mindset, and performance, and share personal stories and learnings to bring you the latest insights and tips. Think of this as your go-to space for real talk about all things health and optimizing your life. Ready to unlock your best self? Let's dive in. This is the Longevity and Lifestyle Podcast.

My guest today is Dr. Nathan Bryan, a world-renowned expert in nitric oxide biochemistry and physiology, a molecule so powerful It's been called the miracle molecule for its role in cardiovascular health, metabolism, longevity, and even brain function. With over two decades of pioneering research, hundreds of peer-reviewed publications, and multiple patents to his name, Dr. Bryan has been at the forefront of discovering how nitric oxide impacts everything from energy production to disease prevention to peak performance. As the founder and CEO of Bryan Therapeutics, N101, and Bryan Nitroceuticals, he's bringing science to the real world. Today we'll discuss the future of cardiovascular health, the longevity-boosting effects of nitric oxide, and why so many of us are unknowingly walking around with a dangerous nitric oxide deficiency. If you're looking to improve your energy, optimize your metabolism, enhance your performance, and even slow aging, this episode is a must-listen.

Please enjoy.

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Welcome to the Longevity and Lifestyle Podcast, Nathan. It's such a pleasure to have you with us today.

Claudia, thank you so much. Great to be with you.

Before we dive into all things nitric oxide, I understand you own an 800-acre working cattle ranch. Nathan, can you perhaps share a little bit about this? Was it a childhood dream or did you grow up there? It makes me think of Billy Crystal's City Slickers movie.

You know, that's a great movie. No, I grew up in small town Texas, and, um, you know, I grew up riding horses and around cattle, and so it's been part of my life for really all my life. And then, you know, when I moved back from Boston— I trained in Boston— and then when I moved back to Texas, an opportunity arose where land became, uh, for sale. So I just started buying up, you know, first I think it was 200 or 300 acres, and then new plots began to arise. So now I've Yeah, I got roughly 800 acres and run a couple hundred head of cattle. And, you know, it's a full-time— it's a full-time job. So I've got a staff that obviously helps me because I travel a lot. But now, for me, there's no other way of life. I mean, because we, we grow our own vegetables, we raise our own beef, and, uh, you know, I'm just extremely blessed and fortunate to be able to live that lifestyle and also provide my kids with that environment too. So we're isolated, um, pretty self-sufficient. Got well water, we've got the solar, we've got generators. So we're pretty much off-grid.

That's amazing. What a beautiful contrast to sort of the normal running around craziness of the day-to-day work and then being able to step outside and being so close to nature as well. I'm very envious. So well done, Nathan, for creating something so beautiful. Thank you. Amazing. Oh yeah. So let's dive into nitric oxide. And you've called nitric oxide the miracle molecule for health. Can you explain why?

Yeah, well, you know, probably 30 years ago it was called a miracle molecule, but today it's not. It does miraculous things, but we don't consider it a miracle because miracle implies that you can't explain what it does, or miracle is something that you observe that can't be explained. By conventional science. But, you know, the nitric oxide field has been so prolific over the past, you know, 30 years, really. There's now over 200,000 papers published in the medical and scientific literature. So nitric oxide does a lot of what would seem miraculous things, but we can explain it scientifically. We know how nitric oxide is produced, we know how it signals, we know where it goes, what it becomes, and what it does. So really, at the end of the day, it's a signaling molecule, but it's primarily recognized as its role as a vasodilator, meaning that when it's produced, it dilates the blood vessels throughout the body and improves oxygen delivery, nutrient delivery, tissue oxygenation. But that's just a part of its rich signaling characteristics. But it mobilizes our own stem cells. It's the signal that tells our own stem cells to mobilize and differentiate. It prevents the ends of the chromosomes, the telomeres, from getting shorter. It signals the mitochondria to produce more energy more efficiently with less oxygen. So everything we know about health and longevity is dependent upon the body's ability to produce nitric oxide. So when you understand that, and then you understand a loss of nitric oxide leads to high blood pressure, sexual dysfunction, increased aging, poor energy production, poor wound repair and injury, recover from injury, and shorter lifespan, now it becomes so important and obvious that we have to focus on nitric oxide if we want to live a long, healthy life.

I'm really excited to dive in because it wasn't completely on my radar. And obviously, I have the pleasure of speaking to amazing pioneers like yourself, but all across the longevity spectrum. So you can imagine it's quite a, quite a breadth as well. And so I love, you know, diving deep into something that is so fundamentally important. And I wonder, why do you think— obviously, I know you're in the world of nitric oxide and you probably think everyone knows nitric oxide, but perhaps there's people listening that are like, what is nitric oxide? Why should I focus so singularly on this? And, you know, what are my levels? How am I supposed to find out about this? Are they decreasing? So maybe you can take us a little bit on that journey of why people listening should really be focusing on this. I know you touched on a few points, but how can they test where they are and what is happening over time as we age to our nitric oxide levels?

Well, you know, you hit on a very good point. The people in the scientific community have been aware of nitric oxide. You know, we have international nitric oxide meetings now for the past 25 years where we bring the world's experts together. But, you know, I taught in medical school for a number of years, and what I quickly realized that most people in the lay public and even patients seeing physicians don't understand what this molecule is. And so really my, my objective was to bring about this global awareness and you know, I've published over 100 peer-reviewed papers in the scientific literature. I've edited and written— Congratulations. —mathematics books. But, you know, no one understands what this is in the general public. And so that's why I think these conversations we're having today are so important. But now, here's what the science tells us, is that when you lose the ability to produce nitric oxide, that's now recognized as the earliest event in the onset and progression of chronic disease. Things like cardiovascular disease, which remains the number one killer of men and women worldwide. It's the root cause of what we call erectile dysfunction or sexual dysfunction in both men and women. Loss of nitric oxide is what leads to the onset of dementia and Alzheimer's. Nitric oxide deficiency is a symptom of— or diabetes is a symptom of nitric oxide deficiency because we published in 2011 that nitric oxide is required for insulin to do its job and for to clear glucose from the circulation. So to answer your question, there's really— and the challenge has been, how do you know if you're nitric oxide deficient? Yeah, because if you go to your, your doctor, your primary care physician, or healthcare practitioner, it's not like vitamin D or triglycerides or these other kind of markers you can get from drawing blood. Because perhaps I failed to mention, but nitric oxide is a gas, and when it's produced inside the lining of the blood vessels or in a cell, it's gone in less than a second. So it's not a number that we can pull from your blood and say, oh, well, your nitric oxide levels is this, it needs to be this. I mean, we can do this through medical devices, functional instruments that give us a sense of what we call endothelial function and flow-mediated dilatation. But really what we, what we rely on are symptoms. Because once we understand what symptoms arise when you start to become compromised in the ability to make nitric oxide,, then we can determine what your nitric oxide levels are and what they should be. So we follow a hierarchy of symptoms. So if you become compromised in your ability to produce nitric oxide, usually— and again, this isn't kind of a global statement, but kind of on average it's a safe bet— but if you develop erectile dysfunction, then that's a sign of nitric oxide deficiency. Because if you can't dilate the blood vessels of the sex organs because can't make nitric oxide, then you don't get engorgement. And that's what's responsible for erections in both men and women, by the way. Then if your blood pressure starts to increase, then that's a sign of nitric oxide deficiency. Because think about this, and it's basically simple physics. We have a finite volume of blood that we're pumping through our entire vascular cardiovascular system. And if we can't make nitric oxide, now those blood vessels become chronically constricted. So now we're pumping the same volume of blood through a smaller volume, and blood pressure goes up. And 2 out of 3 Americans have an unsafe elevation in blood pressure, and I think that's probably a global statistic, and it's not just the U.S. So that's number 2. Number 3, you start to develop metabolic disease, things like insulin resistance, because nitric oxide is part— when insulin is secreted from the pancreas, it binds to the insulin receptors, and then initiates a series of intracellular signaling cascades. And part of that is activation of nitric oxide inside the cell. And if we can't make nitric oxide, then glucose isn't cleared from the circulation. So we become resistant to the actions of insulin, or insulin resistant. That's number 3. Then 4, you become exercise intolerant. If you can't, you know, do 20 or 30 minutes of exercise without getting short of breath and you know, tightening in chest and angina, what we call exertional angina, then that's a symptom of nitric oxide deficiency. And then fifth is you start to develop brain fog and cognitive decline, because if you can't regulate blood flow to the brain, you can't recall memory. And again, this leads to insulin resistance. You get proteins that misfold, and those are amyloid plaque and tau tangles, and that's what we call Alzheimer's. So that's just a symptom of nitric oxide deficiency. So really, all of the poorly managed chronic health conditions that at least the US doesn't do a good job in treating can all be traced back to a lack of nitric oxide production. So if we can focus on restoration of nitric oxide, we can ameliorate or mitigate a lot of these symptoms and disease processes.

Yeah, because it's, it's really sounding like such a fundamental piece across the whole system, right? The whole human functioning system that have so many cascading effects across the board. So thank you so much for elaborating on that, because many people focus on the, you know, farther down the road. My mother unfortunately suffers dementia, but now we know it's a type 3 diabetes. There's a huge metabolic health role, even gut health role that goes in there as well. But going back also to the ability of nitric oxide to support a healthy cellular function, you mentioned before it's hard to test for it. So help, help us understand, help listeners understand, you know, let's say we're talking about someone who's 30 years old or 40 years old or 50, right? Like, what should they be paying attention to? I know you mentioned some of the symptoms, but maybe some women are saying, oh, I don't know, is that, you know, hormonal? I'm, you know, haven't started HRT yet. How do I know where to start? Or is there a protocol that I can already follow that will ensure my nitric oxide levels remain at the right level, whatever that is? Or is there a right level? I guess is another question for you too.

No, there, there is a right level. We know how much nitric oxide you're supposed to make, and we've done this through radiolabeled isotope experiments to figure out, you know, how much nitric oxide is produced in the lining of the blood vessels per day. We understand now that there's a dietary influence on the foods we eat, the presence of bacteria, and the requirement for stomach acid production. So we've quantified that. So we know how much nitric oxide you're supposed to get in a day, and we can recapitulate that and give that back in the form of product technology now. But look, I think to answer your question, it's nitric oxide's foundational, but you know, it's not a panacea. It's not an end-all be-all cure-all, and it's not a silver bullet. It's not going to fix, you know, hormone disorders. If you have hypothyroidism, nitric oxide, giving nitric oxide is not going to correct that. But what we're finding is that if you, if you start with nitric oxide, and then you start to, you know, interrogate the system in personalized medicine and figure out what else may be going on and address those, then that's the best protocol. And the other thing is we find, okay, if you, if you focus on thyroid or HRT in women or men, but you don't first fix the nitric oxide, then all those therapeutic interventions aren't going to have the designed effect because, again, if you have poor circulation and let's just say reduced blood flow to the thyroid gland or to the hypothalamus or to any endocrine organ, then you're not able to sense that, you're not able to respond to it. So we first have to dilate the blood vessels, improve tissue oxygenation, so now that those target cells can actually function. So focus on nitric oxide first, and then start to do everything else. Because if you have endothelial dysfunction and your cells can't make nitric oxide and you do hormone replacement therapy, part of the benefits of HRT and even, you know, regular hormone signaling, whether it's estrogen in women or testosterone in men, it activates and stimulates nitric oxide production. And that explains the cardioprotective benefits of premenopausal women who make sufficient estrogen, or correcting and mitigating the increased risk of cardiovascular disease and HRT. We have to, you know, focus on restoring the function of the enzyme that makes nitric oxide. So now we can activate and stimulate it with estrogen or testosterone, and you can focus on that. But yeah, it's not going to replace magnesium deficiency or iodine deficiency or any other micronutrient deficiency. Focus on nitric oxide, do additional testing, and then figure out what you, the n 1, is deficient in or toxins you may be exposed to and address that.

Yeah, I think that's, um, very, very helpful to understand. So it's that foundation that you can restore essentially, and then on top of it, any of the specialized issues that you are having, then you go and correct that as well. But if you don't fix the foundation, there's no point painting the house if the, if the foundation is falling apart. It sounds like that. Super helpful. Thank you for explaining it that way. Let's touch on a little bit more in depth heart disease. And we know it's, as you mentioned, the number one killer worldwide. What do most doctors and even cardiologists get wrong about nitric oxide's role in preventing heart disease? And what should they be really focusing on instead?

Well, I'm not sure they get it wrong. It's just ignorance. You know, most cardiologists aren't aware of nitric oxide or even, you know, consider nitric oxide as a part of their patient's underlying problem and diagnosis and disease. And because there's no FDA-approved drugs on the market, then it's not part of their therapeutic armament. You know, that's what we're hoping to change, because the problem in diagnostics or early diagnostics in heart disease or cardiovascular disease is we certainly have devices and, you know, non-invasive and even invasive diagnostics. The problem is it's not always predictive, and the value is prognostics and predicting disease progression, or, and even diagnostics too. So the problem, and again, these are US statistics, but 50% of the people who die from sudden cardiac death from an acute MI have less than 50% obstruction in the coronary arteries. So when you hear this all the time, you go to your cardiologist as a preventive measure,, and they do exercise stress tests, they do diagnostic angiograms where they look at the, the patency of the coronary arteries to see if there's any obstruction. And yet we see in a lot of these, you know, less than 10-20% occlusion of the coronary arteries. But the problem is that plaque, that underlying plaque is vulnerable and soft. So then that plaque ruptures and it causes sudden cardiac death or acute MI. And then you have other people who go in for, you know, a coronary angiogram, and again, you have 60-70% occlusion of the coronary arteries, but yet they don't exhibit any symptoms because it's stable plaque. I mean, yeah, there's, there's an obstruction and a little bit of blockage going through the coronary arteries, but it's completely asymptomatic, and the risk of those patients having an acute MI or a thrombus or an embolus, you know, is really pretty low. So just looking at the kind of the physical characteristics of the coronary arteries really provides no prognostic value. But what you have to look at is the vascular reactivity. Are these blood vessels still reactive to stimulus where they can dilate in response to increase in shear stress upon exercise? So what we have to focus on is, because again, looking back, what starts the development of atherosclerosis? And it's when we lose the ability to produce nitric oxide in the lining of the blood vessel, then you start to get plaque deposition, you get what we call smooth muscle hyperplasia, you get the plaque development, then over time that plaque becomes unstable, it ruptures. And that's, that explains the number one killer of men and women worldwide. But now going back, we understand if we can prevent the vascular loss of nitric oxide production, you don't get the plaque deposition, you don't get unstable plaque, and you don't have a heart attack or stroke. So again, everything traces back to the production of nitric oxide. And so when we lose the ability to produce nitric oxide, that sets the stage, right? But the functional loss of nitric oxide precedes these structural changes that you see in coronary angiograms or through ultrasound on the carotid by many years, sometimes a decade or more. So if you have an increase in your media thickness, your intima, then that tells us you've been deficient of nitric oxide for many, many years. So that's what we have to focus on. And again, there's no blood markers. We, we see an increase in things like myeloperoxidase and unstable plaque. You can see an increase in C-reactive protein, this acute phase marker of nitric oxide production. And so nitric oxide has been— in fact, some of my patents on a method of reducing inflammation, and we can lower C-reactive protein by 37% in 30 days just by restoring nitric oxide. So again, you have to look at the entire clinical picture and don't rely on a single marker or diagnostic because, um, really it's, it's the whole picture that matters.

What would be some questions you would recommend people listening who potentially have family history of heart disease or potentially feel that they could be on that path? What are the questions they could ask their healthcare physician, um, or professional around nitric oxide, knowing that potentially the person sitting across from them might not be that familiar? So what would be that conversation you would encourage them to have?

Well, I think you have to do meaningful testing, and really the only meaningful test that we have a sense of nitric oxide production is an old technique. It's called venous occlusion plethysmography. And so what— in, in these devices you can actually occlude blood flow into the brachial artery. So it's done with a blood pressure cuff, and then you occlude the blood vessel in the brachial artery for 5 minutes. So your hands will get a little bit tingly because there's no blood flow. And then when you release that cuff, the normal physiological response would be to dilate those blood vessels really quick because to increase oxygen and blood supply to that part of the body that's been deficient in blood supply for the previous 5 minutes. So if those blood vessels can make nitric oxide, you get a rapid vasodilation. If those blood vessels don't make nitric oxide, then there's no resultant hyperemia or flow-mediated dilatation, and that's diagnostic for nitric oxide deficiency. Now there's some new, newer age technologies. It's non-occlusive or non-ischemic plethysmography where you can look at the structure and function of kind of what we call secondary arterioles and small blood vessels and how well they perform and how stiff those blood vessels are. So there's non-ischemic— one is called the CV Profiler. There's a number of these devices now, but you have to look at functional measurements because a biomarker in the blood, a stable biomarker in the blood, really doesn't tell us anything about the function of the blood vessels. And it's the function of the blood vessels that matters most. But you can do this, and I, you know, I always encourage people to go and do an exercise stress test if you feel you have risk factors for cardiovascular disease, whether they're symptomatic or asymptomatic. Go and have them hook you up to an EKG, put you on a treadmill, increase the workload, and see if you start to see changes in electrical activity, because that's a functional test. If you can't dilate, if you cannot dilate the coronary arteries in response to increased workload, then that— and you start to get shortness of breath, chest tightening, and you start to see changes in your EKG, then you have ischemic heart disease. And don't, don't let them give you the chemical-based or the stress test, because again, it's not— we have to look at function, functional load, and the ability to dilate the coronary arteries. Or if you get, you know, just walking up a flight of steps, then You don't need, you don't need to go to a doctor or cardiologist to measure it. If you get tightness in chest or shortness of breath walking up a flight of steps, then that's cause for concern. And then really the canary in the coal mine is ED. If you can't dilate the blood vessels when you're becoming intimate and you're stimulated sexually, then that tells us you have endothelial dysfunction. And if you have endothelial dysfunction in the vascular bed of the sex organs, you have that same dysfunction in the blood vessels of the heart, the brain, the kidney, the liver. It's a systemic disease.

So ED is the canary in the coal mine. So for, yeah, people listening, that it's something to really get on quickly before it becomes a major issue, I guess, as well. And so to have those educated conversations, to point to people like Dr. Nathan as well for resources that their physician could also hopefully take the time to understand a bit better as well and to better help them. So thank you for sharing that. Let's have a look at nitric oxide, longevity, and anti-aging. So emerging research suggests nitric oxide can enhance neuroplasticity, which I think is really fascinating, improve synaptic function, and even slow cognitive decline. How do you see this translating into real-world longevity applications?

Well, I think it's, it's certainly the anti-aging molecule, the longevity molecule. And I think the future of medicine is going to be dependent upon nitric oxide-based therapies and nitric oxide product technology. Because— and I call this the unified theory of aging, of the unified molecule of aging, many years ago. Because if you look at the objective measures of longevity, there's really 3 main functions, or 3 main kind of endpoints we look at. It's telomere length. So telomeres are the ends of the chromosomes that can become shorter with each cellular division. And it's very clear that the shorter the telomeres, the shorter the lifespan. Longer telomeres, longer lifespan. And nitric oxide is what activates an enzyme called telomerase that prevents the telomeres from getting shorter. They're like the caps on the end of the—

caps on the—

yeah, it's kind of like the, um, the end of a shoestring, right? They're the caps and, you know, prevents the fraying. Exactly. Good analogy. So yeah, if we can't make nitric oxide, we don't get telomerase activation, our telomeres get shorter, we have shorter lifespan. So that's absolutely essential. Nobel Prize was awarded for this years ago. Then the other thing that I mentioned earlier was stem cells. Nitric oxide is the signal that tells our own stem cells to mobilize and differentiate. So aging is just the inability to repair and replace cells that function properly. Right? So if we can't, if we can't make nitric oxide, we don't get mobilization of stem cells. We get senescent cells or zombie cells that aren't replaced and they become dysfunctional and we get end organ disease and we eventually die from that. So, and nitric oxide again tells our stem cells to mobilize, differentiate, and repair and replace dysfunctional cells. And then number 3 is mitochondrial function. You know, every age-related chronic disease is associated with lower numbers of mitochondria per cell. And less efficient ATP production in those mitochondria. And nitric oxide is what induces mitochondrial biogenesis and improves the efficiency of energy utilization by the mitochondria. So if you can't make nitric oxide, you get shorter telomeres, you, you don't get the stem cell mobilization, and you become energy inefficient. And to the contrary, if we can restore and reproduce nitric oxide, you get more mitochondria, more efficient energy production, more stem cells in circulation, and longer telomeres. And that's the basis for longevity. So it's absolutely foundational and essential if you want to live a long, healthy life free of disease.

It's the foundational stone there. I had a timeline, I don't know, on recently discussing Urolithin A's role in mitophagy or the autophagy of mitochondria. What is the correlation with, I guess, urolithin A, nitric oxide, or how's that been looked at, urolithin A, nitric oxide, and the mitophagy, which is such a key component, right, to remove the senescent cells, the senescent mitochondria?

Have you seen any research on that? Not directly related to urolithin A and nitric oxide, but again, it's a process and it's, it's part of cell signaling in the body because, you know, if we, if we take up and, and and kind of self-eat autophagy and mitophagy the mitochondria, but we don't have the ability to induce more mitochondria that work efficiently, then it's really no, no means to an end, right? So everything is working in synergy, and we have to be able to control intracellular signaling. You know, that's why the integrity of the cell membrane becomes so important, because the cell the single kind of function of life, has to be able to sense its outside environment, sense that and signal intracellularly to turn on certain things or turn off certain things. And without the integrity of the cell membrane, then we lose that signaling aspect. And that's why, you know, it's very dangerous to get your cholesterol below 200 because that affects the integrity of the cell membrane. That's why seed oils are damaging because they again disrupt the membrane fluidity and disrupt that intracellular signaling. So all of these kind of signals, whether it's urolithin A, whether it's insulin, whether it's, you know, other agonists, have to be able to transduce through that 7-transmembrane signaling protein and then initiate intracellular signaling and cascades to induce mitochondrial genesis, turn on longevity genes, slow down inflammation. But yeah, everything eventually is connected because it's a series of cell signaling and signal transduction that's dependent upon many, many things. Nitric oxide is just one of them. In fact, it just happens to be, in my opinion, one of the most important.

As we mentioned before, that aging is often defined as the gradual decline of nitric oxide production. And what's the, the secret to maintaining nitric oxide levels as we age? Are there any non-obvious habits or micro-optimizations people could implement daily to sustain high nitric oxide production? Like, what are some things that you do, for example? Sure.

Well, you know, now that we understand how the human body makes nitric oxide— because you, you can't start to inform on therapies or strategies if you don't know all the ways the body makes nitric oxide— and, and we know what goes wrong in people that can't make it. So it's really two simple philosophies. Stop doing the things that disrupt nitric oxide production, and then start doing the things that we've proven clinically to promote and sustain nitric oxide production. So we'll go through this one by one because these are very important.

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For those that don't know me, I'm Claudia von Boeselager, former Goldman Sachs investment banker and serial entrepreneur turned longevity and peak performance coach. After reversing my biological age by 17 years and counting, I now help high achievers like you do the same. My peak performance and longevity coaching is designed exclusively for visionaries, entrepreneurs, and leaders who refuse to settle for burnout, fatigue, or suboptimal health. Together, we'll optimize your energy, longevity, and performance so you can thrive in business and life. This is a bespoke, science-backed coaching experience integrating cutting-edge biohacking, longevity science, and high-performance strategies tailored to your unique biology and goals. If you're ready to unlock your next level, let's talk. Book a complimentary exploratory call now. Just answer a few quick questions to get started. Head to the show notes for the link, and I look forward to speaking with you.

So number 1 is you have to get rid of sugar in your diet because sugar is sticky. And the analogy I like to make is if you have a soda or orange juice or some sugary beverage and you spill it on your countertop, you come back the next day, it's sticky, right? You can see it. Yeah, that's what happens when we have elevation of sugar in, in our, in our body. It sticks. And glucose, which is the primary energy source, or what most sugars, sucrose is metabolized to, or fructose, and we see an elevation in glucose. And glucose is, as the name implies, glue, glucose. So it glues things together. It makes proteins stick together. It makes platelets stick together. And in biochemistry, enzymes have to undergo conformational changes so they can transfer electrons from one thing, one place to another. But if we have sugar stuck to it, it's locked, it's glued in a conformational state., and it can't do its job. And that's sugar stuck to hemoglobin is what we measure in hemoglobin A1c. And hemoglobin is the archetypical protein because to deliver oxygen, it has to undergo a conformational change when it goes from the arteries to the veins. And if sugar is stuck to it, it can't deliver oxygen and it can't pick up CO2. So we become anoxic, we develop, you know, acidosis, and that's metabolic disease. So you have to eliminate sugar from your diet. Number 2, you have to stop using mouthwash, you know, because we discovered and others discovered that there's bacteria that live in the mouth on the crypts of the tongue that are responsible for the continuous production of nitric oxide. And if you kill these bacteria, you shut down nitric oxide production, and we see an increase in blood pressure. So the antiseptic mouthwash, the chlorhexidine, the Listerine, the Scope, anything that's labeled as antiseptic, you must stop.

Yeah, just as a quick anecdote to that, we've had a biological dentist on as well, and I think it's so important for people to think everyone's focused on gut health, but actually the gut begins in the mouth, and it's like an atomic bomb for the, the mouth if you're using these Listerine, uh, products. So yeah, thank you for sharing that.

I just wanted to share a small anecdote. No, well, look, I mean, there's no physician in the world that would advise anybody to take an antibiotic every day for the rest of their life. Right? Because we know it destroys the gut microbiome and it causes systemic disease. Yeah, because it's causing dysbiosis. So by the same argument, why would you use an antiseptic mouthwash every day for the rest of your life? No one, including dentists who are up to speed with current science, would advise you to kill all the bacteria in your mouth every day, sometimes twice a day, for the rest of your life. Because Here's what we know. If you do it, your blood pressure goes up. If you use mouthwash, you lose the protective benefits of exercise, and it's causing systemic disease similar to the systemic effects of an antibiotic. So you have to get rid of mouthwash. We have to support the oral microbiome. We can't kill it. The other big problem, at least in the US, maybe in other countries too, is fluoride. You know, fluoride is a neurotoxin. It's a poison. It's an antiseptic. And it completely shuts down your thyroid function. You know, there was a paper published in the US by the National Toxicology Program, the organization that's kind of tasked with figuring out what's the toxicity of certain environmental toxicants that we're exposed to, and fluoride has been shown to lower IQ in kids by sometimes 7 points.

It's wild.

I heard— so they put fluoride in our drinking water, there's fluoride in our toothpaste. And if you look at the back, and, you know, companies sell toothpaste all around the globe, but if you're using a fluorinated toothpaste, look at the back of your Crest or Aquafresh or Colgate, and it'll say only use a pea-sized toothpaste, because that little pea-sized bit of toothpaste contains about 0.5 milligrams of fluoride. But most people put 10 times that, sometimes 20 times that. And now we're exposed to 5, 10 milligrams of fluoride, and this is a very small molecule. You don't have to swallow it for it to have toxic effects. It's, you know, molecular weight of 19, I believe. So it's absorbed immediately in the mucosa and it goes systemic. But if you look at the back of your toothpaste, it goes, if you swallow this, call poison control. And it gives you, at least in the US, a poison control number. So they're putting poison in our toothpaste, they're putting poison in our water supply, and we wonder why we have an epidemic, a pandemic of hypothyroidism, while we have dysbiosis, while kids have learning disabilities today. Their IQ is lower than it was, you know, 70, 80 years ago before they started putting this poison in our drinking water. Yeah, increased rates of ADHD, etc. Yeah, yeah. Fluoride in your toothpaste, antiseptics are really bad news. And then the other big contributor that leads to nitric oxide deficiency are antacids. These are what we call proton pump inhibitors. The Prilosec, the Prevacid, the Nexium, the omeprazoles of the world completely shut down nitric oxide production. And the consequences of that are now we're seeing a 40% increase in heart attack, stroke, and Alzheimer's. Wow. And people who have been on PPIs for 3 to 5 years. So These are very dangerous drugs. You know, the responsible thing to do was completely take these drugs off the market. So just— these are worse than that. Yeah, these are worse than the Vioxx and the Celebrex, the COX-2 inhibitors from 25 years ago, causing increased heart attack, stroke. And these drugs were taken off the market for a period of time. Now I believe they have a black box warning on them, but the same should be for proton pump inhibitors. And in fact, in the U.S. If you're admitted to the hospital, whether it's trauma, whether it's influenza-like illness, acute respiratory, or heart attack, standard of care, no matter what you're in the hospital for, they give you omeprazole and an antacid. And yet in the US, we wonder why people that are in the hospital don't get better. You have to stay out of the hospital. This has to change the data. It's malpractice and it's negligence to continue to give patients these proton pump inhibitors.

You know, it has to change. 100%. And I didn't realize the statistic is so high.

So 40% increase of heart attacks, etc. Yeah, this isn't risk. These are actual events. You know, that paper was published in 2015. I think in 2024 or 2023, there was data now showing about a 40% increase in Alzheimer's. And they cause— oh yeah, look at the package insert or listen to the commercials. There's already evidence that it causes kidney disease, kidney failure. They develop bone loss because without stomach acid, you can't absorb magnesium, you can't absorb calcium, you can't absorb iron, you can't absorb selenium, chromium, B vitamins. And now heart attack, stroke, and Alzheimer's. What other evidence needs to be presented before the regulatory officials and even the companies that are making these do the responsible thing and eliminate them from our supply.

Yeah. So here's to people listening. Hopefully someone can help to make a change. So just to recap, it was getting rid of the sugars, getting rid of the mouthwash, fluorides, not to drink the tap drinking water or use a very good filter. Careful with toothpaste, pea size, or ideally there are toothpastes out there that don't actually contain fluoride and antacids as well. Yeah. Just curious, I've had Dr. David Perlmutter on as well. We were talking about the difference between glucose, which I really like. It's like a glue, but that fructose can actually be more detrimental— liquid fructose, i.e., from juices and things like that, can be more detrimental than glucose, would— is in the case of nitric oxide.

But would you agree, or is it— no, absolutely. Look, David Perlmutter is a good friend and colleague, and he's the world expert. In fact, he's part of our team to develop our Alzheimer's drug and get to the root cause of, of Alzheimer's. But yeah, fructose is a toxin too, you know. Through David's work, we know that it leads to an increase in uric acid, and uric acid shuts down nitric oxide production. So there is a direct link between these. And so, you know, a good practice is just to eliminate— certainly high fructose corn syrup is a toxin, and that's rampant in the US, and I think it's probably global now. But yeah, eliminate simple carbs, anything that causes an increase in blood glucose, and eliminate soft drinks, sugar-sweetened vegetable or beverages, and just exercise. So it's just really— and then if we move on to kind of what— now that we understand what, what you should stop doing, now you've released the brakes on the body's ability to naturally produce nitric oxide. And then we can, you know, 20-30 minutes of exercise a day or 3 to 5 minutes of high-intensity interval training has been shown to improve and stimulate nitric oxide production. 20-30 minutes of sunlight exposure a day. So if you're going to exercise, exercise in the morning, that first sunlight is very beneficial. And then just throw in a few green leafy vegetables that are enriched in organic nitrate and support the microbiome so that these bacteria can convert that nitrate into usable forms of nitric oxide. And it's really that simple. I mean, but these are lifestyle changes. You know, most of the time it's cost savings. Right? Because if you're not using mouthwash, that's going to— you're not going to spend that money. Yeah. Buy a fluoride-free toothpaste. Get off your antacid drugs. That's cost savings. And then, you know, exercise is free. It's cheap. Sunlight is free and cheap.

So these are cost-saving strategies. And with the green leafy vegetables, especially in the US, I'd say organic is very important. Avoid the glyphosate. Roundup that's in Otherwise That. And what is your view actually with the organic? Because I've had different conversations about this. I obviously focus on buying organic as well, but speaking to people who work in farm areas, and I know you have a cattle ranch, so not exactly the same, but they say, yeah, but the, you know, the neighboring farm is spraying, so the wind carries it over anyway. It doesn't make any sense. Is your view organic leafy vegetables are really genuinely going to be organic, or it will depend the farm, the source, and how well they protect it?

Now look, the glyphosate is— it kills all plants unless they're genetically modified organisms that become resistant to the glyphosate. So if you've got neighbors spraying an herbicide or pesticide, then, you know, those crops won't yield any, any fruit or vegetables because it'll kill them because they're not genetically modified to withstand that poison. But no, look, I think organic is good because you have to eliminate these toxins— the glyphosate, the herbicides, the pesticides that are sprayed on our food. And what you recognize is that if insects and rodents don't eat this food, then why would humans?

And that's the point.

All of these smaller animals, exactly what are they doing? But here's the— here's kind of the caveat. Organic is good because you're not exposed to that. But what we found, and we've published this in 2015, is organically grown vegetables in the U.S. Have typically less nutrients, specifically less nitrate, than conventionally grown vegetables. Because in order to get an organic label in the U.S., obviously no herbicides, no pesticides, which is good, but they put restrictions. You can't add nitrogen-based fertilizers to the soil. Now you can add manure, compost, things like that, but unless you standardize the nitrogen you have no way of knowing what you're adding is going to replete the soil with enough nitrogen to assimilate nitrate or assimilate other micronutrients. So what we do, and we grow our own vegetables here, but I do soil samples. So I'll take, you know, soil samples all around my place and I send it to our US local US Department of Agriculture and they'll do an analysis of what's in the soil, what's lacking in the soil. So then we can develop a custom fertilizer that basically gives back what's missing in that soil. And every part of the country is different. You know, I live in an area where there's what we call sandy loam. So the requirements for that are much different than people, you know, an hour north of me who have blackland, really rich, fertile soil. And that's why I encourage people, you have to do soil samples and then replete what's missing from that soil in that particular environment.. So you can optimize the yield from your garden and your vegetables. But what I grow wouldn't be considered organic because I have to add fertilizer, nitrogen-based fertilizers to the soil. But I certainly don't add the herbicides or pesticides to any of the food that me and my family are eating.

So it's not considered organic, but it's certainly pesticide, herbicide, toxin-free. Yeah. Thank you for differentiating that. Learned something new today. I love it. What should people look out for or avoid when choosing a nitric oxide product? So people wanting to supplement, what are things to look out for?

Well, you know, these nitric oxide supplements hit the market back in the late '90s. So Nobel Prize was awarded for the discovery of nitric oxide in 1998. And really that created kind of a spark in consumer products. And when it was first discovered, so part of the body's ability to produce nitric oxide is dependent upon the enzyme nitric oxide synthase that converts L-arginine into nitric oxide. So there's 3, 3 types of nitric oxide products on the market. There's the arginine, and some people are putting citrulline in products now. And I tell people those really provide no benefit because arginine is a semi-essential amino acid. It's It's produced in every cell through the partial urea cycle. We get it from the breakdown of proteins, whether it's plant protein or animal protein. So we are never deficient in arginine. Therefore, we never need to supplement arginine. And so that's kind of basic biochemical principles. The other consideration, and really a concern, is that there's clinical data now showing that if you, if you've had a heart attack, or if you've got peripheral vascular disease,. And you give arginine, it actually makes people worse. So the VINTAGE trial in 2005 or '06 showed that if you give people who've just had a heart attack L-arginine, it actually caused an increase in death in those patients. Wow. Post-infarct mortality increased. In fact, the clinical trial was stopped halfway through because the steering committee deemed it unethical to give arginine because the placebo was actually performing better than the treatment group. So in the same thing with patients with peripheral arterial disease, patients who got the L-arginine actually got worse, intermittent claudication got worse, quality of life got worse. So just risk-benefit, there's no benefit, and there may be additional risks. So you just eliminate it. So any product that contains arginine or citrulline is typically not necessary. No go. And then the other thing in 2012, you know, beets became a hero vegetable after the 2012 London Games. Everybody was revealed that all these athletes were drinking liters of beet juice. And what we— and there was data showing that beetroot contains inorganic nitrate that produces nitric oxide if you have the right oral bacteria. And then the market's flooded with beetroot products, right? And I've tested these in my lab using analytical equipment, and we find that, you know, about 95% of the beet products that are on the market don't produce any nitric oxide. They provide zero nitric oxide benefit. In fact, there's some beet powders that we've used as placebos in clinical trials because they act as the perfect placebo, right? They're beets, they're desiccated beet powder, but they contain no nitrite, no nitrite. They don't promote nitric oxide. It's the perfect placebo. So beets typically, you know, again, provide no benefit. The other problem is that it's dependent upon the oral bacteria. So if you're taking beets, using mouthwash or you're exposed to fluoride, nitrate is inert, right? We just, we sweat it out, we poop it out, and we pee it out. So those are kind of the two product categories to where really the majority of them provide no benefit. There are some on the market that, that do. We make, we make a beet powder that's actually efficacious and promotes nitric oxide. And then the third are kind of what I termed nitroceuticals. So I trademarked the term called Nitroceuticals because nitric oxide is part of that core term. And what I was trying to do was when I started developing product technology, how does one know that this product actually produces nitric oxide? Because nutraceuticals, you know, there's thousands of products out there and most of them typically in terms of the nitric oxide don't do anything. So how do we differentiate that? So what I've done, because I know how the human body makes nitric oxide, I know what goes wrong in people that can't make it, now we can start to develop rational therapies or product technology. So what we do is we produce nitric oxide. If your body can't make it, then we do it for you. And we do it because we're not dependent upon the bacteria, we're not dependent upon stomach acid. So if you take my products or nitroceuticals, then, you know, we're providing a source of nitric oxide if even if your body can't. And we understand the enzymology and biochemistry to where we can enhance your body's ability to make it on its own. But again, that requires you to get rid of fluoride, stop using mouthwash, and wean off of your mouthwash. But the acute nitric oxide release from taking my products, it still works whether you're on antacids, whether you take fluoride or exposed to fluoride, or use an antiseptic mouthwash.. And that's, that's the difference. And so that's been my challenge over the past several years is how do you differentiate and educate and inform consumers to where they know they can make informed, educated decisions on which products they're buying and which may provide benefit and which, you know, may be a placebo product.

So very helpful to understand that. Is there the nutraceuticals, so the nitric oxide supplementation, the products that you have that have obviously lab tested, et cetera, coming from one of our leading experts Is there a certain protocol you recommend for people to take? Is it not for certain candidates? Maybe you can walk us through that a little bit to understand better.

Yeah, so our— we make what's called an orally disintegrating tablet, an ODT, because you have to understand nitric oxide's a gas. This isn't a pill you can swallow. We actually designed this to have a resident time of 5 to 6 minutes in the mouth. So you put the lozenge in your mouth. As it slowly dissolves, this matrix falls apart, and we're producing nitric oxide gas, and then it's absorbed. It recouples the nitric oxide synthase because it's an oral product. It's restoring the oral microbiome, which is responsible for the production of nitric oxide. So yeah, and it's made in a drug manufacturer here in the US, so we, you know, GMP manufacturing facilities, we go through the same rigor as prescription drugs or even, you know, drug manufacturing. But now I tell people there's only two people in the world who need nitric oxide. The first group are the people who are well and don't want to get sick, and the second group is those who may be sick that want to get well. So if you fall in one of those two categories, you need nitric oxide. You know, I've been taking my nitric oxide product for years, and I take it not because I need it, I take it because I don't want to lose my body's ability to make it. And I think that's the strategy and the paradigm change we have to undergo is because we have to be proactive instead of reactive. You know, medicine around the world, westernized medicine, is a reactive approach. Yeah. And you only go to your doctor if you get sick or have an issue, and then he puts you on medication, and it's a reactive approach. We have to be proactive and take steps to prevent this age-related loss of nitric oxide production. So we don't get sick, so we don't get symptoms, so we don't get diabetes, Alzheimer's, heart attack, stroke. It's a completely different way of thinking, but it's an absolute must or else, you know, the healthcare system's gonna bankrupt the entire world, the global economy.

And people's health are just gonna continue to go down the drain as well. Yeah. So I mean, all about prevention, stepping in on time. Is there a certain, is it one lozenge you take each day? Is that, that what you do? And from the age of 40, 50, 30, is there any, I know that's Have you done trials on that, or is it just for everyone? And is there a risk of overdosing, let's say someone produces high nitric oxide?

Yeah, let's take the last question first. So there's a risk of overdosing. Dose dictates poison. I mean, we can overdose on water, right? You see it on the news. People drink a lot of water over a short period of time, they get volume expansion, hypotonic lysis, and it's deadly. Yeah, so it's no different with nitric oxide. But what we look for in signs of toxicity are an unsafe drop in blood pressure, and what we call methemoglobinemia. So too much nitric oxide will oxidize the iron of hemoglobin and reduce the oxygen-carrying capacity of the red cell. But when taken as instructed with our products, we've never seen that. But yeah, so kind of broad— again, broadly speaking, it's individualized. We're in this area of personalized medicine, but one lozenge once, twice a day, 12 hours apart is sufficient to maintain optimal nitric oxide. But, you know, everybody's different. And in 2011, we published a paper on a pediatric patient, a 15-year-old kid who had a rare genetic disorder, had resistant hypertension, heart disease, kidney disease, and prescription medications were ineffective at lowering his blood pressure. So we dosed him with a lozenge I'd manufactured specifically for that kid. And he had to take one lozenge every 4 hours. And he had blood— he was in the intensive care unit with blood pressure of 210 over 115. Wow. And no prescription medication would lower his blood pressure. So we dosed him the lozenge. And we found with him, one lozenge every 4 hours was necessary to normalize his blood pressure. And with that dosing, we certainly didn't see an unsafe drop in blood pressure. We saw a drop in blood pressure to safe levels. But we monitored him for methemoglobin levels and there was no change in his meth levels. So At least we know in that population, 160-pound, 15-year-old kid, one lozenge every 4 hours doesn't lead to any signs of toxicity. But again, so I think one, one lozenge a day up to at most one every 4 hours is extremely safe. You know, we even had a drug trial during COVID where we were dosing a more potent lozenge in our drug trial. One twice a day in really high-risk susceptible patients, 50 to 80-year-old African Americans with underlying comorbidities. And even that dosing, one twice a day, a higher dose, there was no safety signal in over 100—

over 500 patients that we treated during COVID Amazing. And I think for my audience, we'll link to the products as well if people are interested in, uh, in upping their nitric oxide levels now that we know how important that is as well. Nathan, I'd love to touch on performance, metabolism, and brain function as well.. So we know athletes are using nitric oxide boosters to enhance endurance, muscle recovery, and cognitive function. What's the biggest untapped potential of nitric oxide in the world of peak performance?

Well, it defines peak performance because everything we know about performance, whether it's athletic performance, cognitive performance, or sexual performance, it's all dependent upon adequate blood supply, which is vasodilating, which nitric oxide does, adequate oxygen delivery, which is what nitric oxide facilitates— oxygen uptake and oxygen delivery— mitochondrial function, converting that oxygen into cellular energy. Nitric oxide does that, improves oxygen efficiency by the mitochondria and induces mitochondrial biogenesis. And you got to get the fuel into the cell, you got to get glucose into the cell so you can utilize that through the Krebs cycle to make ATP. Nitric oxide does all of that. And without nitric oxide, you don't get that signaling cascade, and your performance becomes compromised—your cognitive performance, your athletic performance, your sexual performance. So nitric oxide is the—probably the most—well, not probably, I think is the most ergogenic aid of performance that we know of.

And without it, you're just not going to perform. Do you have a memorable client story or athlete testimonial where nitric oxide made a life-changing impact on performance or recovery?

That you could share? No, for sure. Well, I mean, the obvious one was that 15-year-old kid that we, we saved his life with our, with our lozenges. But the other one was, you know, NBA athletes, you know, had an association or relationship with the Miami Heat and Pat Riley. And when they go to Denver to altitude, 5,000 feet— so Miami, obviously at sea level, they go to Denver, play the Denver Nuggets at 5,000 feet. They fly in sometimes the morning of. And, you know, it was revealed that they struggle. All teams struggle. At altitude. So they started taking our nitric oxide product and found that they could actually improve their performance and perform better at altitude. And once that happened, you know, many, most professional teams, whether it's NFL, NBA, use a nitric oxide product because it's been shown to enhance their performance specifically at altitude.

So all the climbers out there looking to summit Everest, listen carefully as well. And what's one thing the average person does in their daily routine that silently destroys their ability to produce? Like, what is the most typical thing you see? Is it the mouthwash?

Is it the glucose? Is it the antacids or the sugar? I think if you had, if you had, if I had to pick one thing, it's, it's sugar. You know, sugar, high carbohydrate, high sugar causes an increase in blood sugar, become insulin resistant. It causes hyperinsulinemia. That's the inflammatory component of diabetes. It completely shuts down nitric oxide production. So I think it's, you know, in the US we're overfed. And not only we're overfed, we're, we're overexposed to sugar, simple carbohydrates, high fructose corn syrup, and it's destroying the underlying metabolism. You know, 9 out of 10 Americans are metabolically unfit. And now it's become a national security issue because we don't even have young boys healthy enough to serve in the military. I mean, it's—

it has to change. And sugar's— sugar's the enemy. Yeah. And ultra-processed food with the seed oils and causing inflammation as well. What differences have you seen between men and women and how they respond to nitric oxide optimization, whether for metabolism or exercise or brain function?

Are there differences? No, there are— there are clear sex differences. In fact, there's some labs in the UK specifically that are looking at the sex differences of nitric oxide production. And we can see this through observational data. You know, premenopausal women are protected from heart attack and stroke more so than their age-matched male counterparts. However, at menopause, their risk actually surpasses that of their age-matched male counterparts. So we're still trying to understand that. Obviously, there's a protective effect of estrogen on activation and stimulation of nitric oxide. If you perimenopausal, premenopausal, you don't have production of estrogen, you lose the stimulation of nitric oxide production. That may partly explain it. Obviously, there are many other confounding factors, but no, you certainly see— so what we do in terms of nitric oxide restoration, there's not a sex difference because nitric oxide is really agnostic to sex, to race.

You produce it, it does its job. We know that nitric oxide plays a role in metabolism. Um, could optimizing nitric oxide be the missing key for weight loss? Do you think some people are struggling with weight loss because their nitric oxide levels are compromised, and maybe also insulin sensitivity you touched on before, and overall metabolic health. So is this a key component if someone is coming from the perspective of, I'm struggling to lose weight, you know, what's happening, my energy levels are low, to also really focus on nitric oxide levels?

I think in obesity and weight loss, it's what we call an epiphenomenon. It may not be directly causal for it, but it's certainly affected. Because again, you know, if you're eating too much carbohydrates, you're not burning it, you're storing it as fat, the fat becomes inflammatory, inflammation shuts down nitric oxide production, and then you get poor circulation, increased risk of diabetes, heart disease, stroke, all-cause mortality in the obese. So I think you have to take a step back. And these GLP-1 agonists now are remarkable drugs at lowering or losing weight in morbidly obese people where diet and exercise have typically failed them. Yeah. So I think it's, it's what we call an epiphenomenon, but again, goes back to the basic principles of nitric oxide's foundational. You have to focus on other things. The GLP-1 agonists are helping that process, but, you know, unless you correct nitric oxide deficiency, uh, you're not going to be metabolically as fit as you would be.

And that's an interesting point with the GLP-1s. For people listening who might be taking an Ozempic, Monjaro, whatever, uh, is it complementary then to also be upping their nitric oxide levels to support the whole system?

Absolutely. It's an absolute must because we now know that there's, you know, symptoms of gastroparesis or gut paralysis in that nitric oxide is what we call the non-adrenergic, non-cholinergic mediator that enhances gut motility. So if you're on these GLP-1 agonists, you must take our nitric oxide to prevent the gastroparesis. And now there's blindness associated with these. So, you know, there's associated risk with everything. And so you just have to understand, again, the risk-benefits and understand the risk to the extent that you can mitigate those risks and prevent bone loss, muscle loss. So, you know, if you're taking these, you must take an amino acid in the morning to prevent bone loss and muscle loss, because it's not just the fat loss.

You're losing protein and you're losing bone mass and muscle mass. As we finish up today, I'm aware of the time and I've still got so many questions, Nathan, so I'd love if we could do a round 2 at some point. But, um, a dear friend of mine has MS, and part of it, sometimes she loses her vision. I have another friend who has type 1 diabetes, losing eyesight. So is nitric oxide something that should be taken by people with these diseases, including also the type 1 diabetes, because of the risk of losing their eyesight?

Well, I think it can certainly help. It's probably not causal for that. There are other toxins exposed to that maybe cause symptoms of MS, neuromuscular symptoms. But, you know, the eye has to have adequate blood supply. We know in glaucoma patients, age-related macular degeneration, there's a vascular component to that. That's, you know, the eye is not getting perfused, so it can't perform. If we give nitric oxide, dilate the blood vessels, restore blood flow, reduce inflammation, then things seem to work better.

Great. Nathan, if you are looking forward to the future, what's your vision for the future of nitric oxides? Where would you— what would you love to see in the next 2 to 5 years in terms of awareness and use across the board, from practitioners to the population, in terms of knowledge, awareness, and use of nitric nitric oxide supplementation?

Well, that's a perfect segue to my shameless plug of my new book, The Secret of Amazing. Now, but I— look, the future is dependent upon nitric oxide. You know, we've got active drug programs for, um, through my company, Bryan Therapeutics. We're developing drugs for heart disease, Alzheimer's, topical drugs for diabetic ulcers. But nitric oxide is the future of medicine. The future of our entire mankind is dependent upon global awareness and safe and effective product technology. But, you know, in this book I tell the story of nitric oxide, how it was discovered, what led to a Nobel Prize, kind of my personal journey of discovery. And really, the last chapter is what's next, where I predict and look forward to the future. So I encourage everybody to read this book. This is really the story of nitric oxide. It's bringing the science to life. You can find it wherever books are sold.

You can go to NathansBook.com, buy it at Barnes Noble, Amazon. We'll link it all in the show notes for people listening and, and watching as well, which would be great. Nathan, it's been such an inspiring conversation. Thank you so much for taking on the nitric oxide journey. Um, so fascinating. For listeners who want to dive deeper into nitric oxide, there's your book. Is there any other resources, or where can they find what you're up to?

Um, maybe websites? Yes, I have a dedicated YouTube channel where all we're focused on is educating and bringing awareness around nitric oxide, and that's Dr. Nathan S. Bryan Nitric Oxide. You can follow me on social media, Instagram, Dr. Nathan S. Bryan. Same for LinkedIn, uh, Twitter, I'm at Dr. Nitric. Um, what else? I'm searchable.

You can put me in any search engine and, uh, you'll find me. You're findable. Nathan, do you have a final ask, a recommendation, or any parting thoughts or message for my audience today?

Yeah, look, knowledge is power, but only if you implement it and act on it. And so I think I think, you know, we've had a, you know, a decade or a generation of ignorance on nitric oxide because it's still new in the medical literature. So my only recommendation was get us informed and educated on the real science of nitric oxide. And I think that's been my motivation is to take the latest, greatest up-to-date science and kind of distill it down into something that's digestible for, you know, the layperson, the non-scientist, non-physician. But, you know, it's absolutely essential for optimal health and wellness.

So, digest all you can on nitric oxide and implement these really simple lifestyle strategies to prevent the decline in nitric oxide production. Beautiful. Thank you so much for taking the time to come on today. Thank you, dear audience, for tuning in.

It's been a real pleasure. Thank you. Thank you. Hi everyone, it's Claudia again. Before you take off, would you like to get a short email from me to you several times a month with top tips, insights, and strategies to help optimize your life, health, and business? This could be interesting posts or articles I've read on life and long longevity optimization, cool biohacking or lifestyle products that I've discovered, and other fun things to help you be at your best. It's a very short piece of inspiration for you, so if you want to receive it, check it out by going to llinsider.com.

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