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In this Longevity and Lifestyle Podcast episode, host Claudia von Boeselager interviews Sarah Kennedy, founder and CEO of Calocurb Limited, about the biology of hunger and a novel, plant‑derived weight‑management product. Kennedy explains how bitter taste receptors (TAS2R) are distributed throughout the gastrointestinal tract and, when activated in the upper gut, trigger the release of appetite‑suppressing hormones CCK, GLP‑1 and PYY, while activation in the stomach releases ghrelin. She describes the evolutionary rationale for bitter compounds as appetite suppressors and how plants and humans co‑evolved this signaling system. The conversation then shifts to the 15‑year, $30 million New Zealand government‑backed research that identified a hop‑derived bitter molecule, amarosaid, as a potent stimulator of these receptors. Clinical trials (male and female, including menstrual‑cycle‑controlled studies) showed 600 % increases in CCK and GLP‑1, 400 % in PYY, an 18 % average reduction in calorie intake, and up to 80 % reduction in hunger during fasting. Kennedy compares Calocurb to injectable GLP‑1 drugs (semaglutide/Ozempic), noting Calocurb’s lower efficacy (≈18 % vs 25 % calorie reduction) but its natural, short‑acting mechanism that avoids chronic hormone suppression and the “valley of death” rebound hunger seen when stopping GLP‑1 therapy. She outlines practical dosing (an hour before meals, twice daily, on an empty stomach) and special considerations for women (luteal‑phase appetite spikes, menopause). The discussion expands to longevity, emphasizing how excess visceral fat drives inflammation, insulin resistance and aging, and how appetite control can improve metabolic health. Kennedy also shares personal nutrition habits—high protein intake, careful sugar monitoring, and a salad‑centric diet—and the branding story behind the Calocurb name. The episode includes sponsor messaging, discount code details, and a call‑to‑action for listeners to follow Calocurb online.

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