What causes skin aging? Find out more on The Longevity & Lifestyle Podcast #shorts #aging #skinaging

Name: What causes skin aging? Find out more on The Longevity & Lifestyle Podcast #shorts #aging #skinaging
Uploaded: 2023-03-24T14:11:30+00:00
Duration: 43 s
Channel: Claudia von Boeselager
Description: In this short excerpt from The Longevity & Lifestyle Podcast, the speaker explains that a key factor behind aging of skin and other tissues is the…

24 Mar 2023 · 1 min

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In this short excerpt from The Longevity & Lifestyle Podcast, the speaker explains that a key factor behind aging of skin and other tissues is the buildup of senescent cells—cells that have exhausted their capacity to divide due to accumulated DNA damage. While senescence serves as a protective mechanism to prevent these damaged cells from turning cancerous, the efficiency of this defense declines with age. Consequently, senescent cells accumulate in tissues and release inflammatory signals (the senescence‑associated secretory phenotype) that damage neighboring healthy cells, accelerating the aging process across the body.

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One of the main drivers of aging, and this is not only true for skin but for different organs and tissues in our bodies, is the accumulation of aged, damaged cells, also called senescent cells. These are cells that have reached their limit in replication, so they have accumulated a lot of mutation damage, and because of that, they stop dividing, which is good. Otherwise, they could become a cancer, a tumor. So So this is a mechanism of defense from our body. When we grow older, we lose that efficiency. So they start to build up in our tissues and they start secreting inflammatory signals that basically spoils the healthy cells around to age faster.