You Taste Food With Your Gut

Name: You Taste Food With Your Gut
Uploaded: 2026-01-13T21:26:53+00:00
Duration: 58 s
Channel: Claudia von Boeselager
Description: In this brief presentation, the speaker reports findings from a study that collected 300 biopsies during upper endoscopy and colonoscopy, revealing that…

13 Jan 2026 · 1 min

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In this brief presentation, the speaker reports findings from a study that collected 300 biopsies during upper endoscopy and colonoscopy, revealing that bitter taste receptors (TAS2R) are present throughout the gastrointestinal (GI) tract, not just on the tongue. Activation of these receptors elicits location‑specific hormonal responses: in the stomach, stimulation of TAS2R triggers the release of ghrelin, a hormone that promotes hunger; in the upper duodenum and proximal small intestine, activation induces the secretion of the appetite‑suppressing hormones cholecystokinin (CCK), glucagon‑like peptide‑1 (GLP‑1), and peptide YY (PYY). The speaker links these mechanisms to the use of aperitifs, which may exploit stomach‑based TAS2R activation to stimulate appetite, and highlights the broader role of gut taste receptors in regulating food intake.

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They took 300 biopsies from right endoscopy and colonoscopy from right down the gastrointestinal tract and actually showed we have taste receptors right down our gastrointestinal tract. So not just on our tongue, we have 25 on our tongue, but they go right down through our gastro and these are called TAS2R, but they're bitter taste receptors. And at different locations in the gastrointestinal tract, they release different hormones. So in the stomach, if activated, they release ghrelin, the hunger hormone, which is why we have a lot of these aperitifs, as you know, because they're to stimulate hunger or to get you ready to eat. But if you go past the stomach into the upper duodenum or upper gut, they stimulate CCK, GLP-1, and PYY. So 3 of the very powerful appetite suppressing hormones.