#238 Data & AI for Improving Patient Outcomes with Terry Myerson, CEO at Truveta

26 Aug 2024 · 40 min
Episode

26 Aug 2024 · 40 min

0:00

In this Data Framed podcast, host Ritchie interviews Terry Myerson, CEO of Truveta, about the massive challenges and opportunities of using electronic health record (EHR) data to accelerate healthcare research and improve patient outcomes. Myerson outlines three core problems with current health data – strict privacy regulations, fragmentation across many providers, and the predominance of unstructured clinical notes. He explains how Truveta tackles privacy through HIPAA‑compliant de‑identification (safe‑harbor vs statistical risk‑based methods) and how the company builds a consortium of 30 leading health systems (covering ~18% of U.S. clinical care) to break data silos and add payer‑side longitudinal information. The conversation dives deep into the data‑engineering work required to normalize billions of records, map semi‑structured fields and free‑text notes to medical ontologies, and apply large language models (LLMs) for natural‑language processing. Myerson stresses the need for “regulatory‑grade” AI: high‑quality, expert‑curated training and evaluation sets, transparent precision/recall reporting, and rigorous validation to satisfy FDA guidance. He shares concrete real‑world evidence successes – comparative effectiveness of weight‑loss drugs (Mounjaro vs Ozempic), safety signals for stents and heart valves, and rare‑disease cohort studies – illustrating how real‑world data can complement or even replace parts of traditional clinical trials, especially in phase‑4 monitoring. The business model relies on compensating health systems for de‑identified data use, targeting B2B customers (pharma, academia, government) while planning future citizen‑science access. Finally, Myerson envisions a future where continuous, real‑time learning—similar to telemetry in tech products—drives faster innovation and better care across all disease areas, approached horizontally as a connected health graph.

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