The Secret Cause of Cancer That No One is Talking About

In this monologue Dr. Dino Prato argues that cancer is rarely caused by a single factor such as genetics or sugar; instead, it arises from a complex interplay of epigenetic changes, immune dysfunction, mitochondrial damage, hidden infections, mold/mycotoxins, chemical toxins, heavy metals, and lifestyle influences. He critiques conventional oncology for relying on a limited set of tumor markers, imaging, and one‑size‑fits‑all protocols that ignore these deeper drivers, leading to suboptimal treatment choices for most patients. Prato promotes a functional/precision oncology model that employs deep multi‑omics profiling (over 1,000 markers, RNA/DNA sequencing, immune spatial biology, and immune profiling) to identify individual “fingerprints” of cancer and its supporting environment. He outlines practical steps patients can take, including asking specific questions about immune support, detoxification, mitochondrial health, and targeted therapy suitability, and recommends comprehensive testing for infections, toxins, and metabolic dysfunction. Throughout, he emphasizes that restoring immune surveillance, mitochondrial function, and reducing chronic inflammation can improve treatment response, enable micro‑dosing, and sustain long‑term remission, positioning precision oncology as a more effective, personalized alternative to the current cancer care paradigm.
Chapters
There's an underlying cause of cancer that no one's really paying attention to, but it could change the way research is done and the way we treat cancer forever. My team and I have been treating cancer for over 25 years, and it has been a huge work of thousands and thousands of patients. And what I'm gonna walk you through is what I believe is one of the most unappreciated drivers of cancer and why mainstream care isn't looking at it, and the specific things I'd have you bring up to your next doctor's appointment so you can get help immediately. And here's a secret. It's not one thing. That's why most people miss it. The secret cause of cancer is not just sugar. It's not just genetics or toxins or inflammation or a hidden breakdown in a mutation. The terrain of your cells, a hidden infection, molds, mycotoxins, chemical toxins, heavy metals, mitochondrial dysfunction or damage. See, it's more than all of this. It's more than just poor metabolic function or weak autophagy or p53 mutations. Mitophagy, the cleaning up of your mitochondria., and one of the biggest ones, an immune system problem where it's no longer seeing the target and able to clean up the cancer cells, meaning your immune system is being evaded from fighting the cancer because over 10,000 times a day, if you have a healthy immune system, it knows to get rid of rogue mutated cells when it's healthy, when it has the right markers. And that's one thing people aren't talking about. Most patients think cancer starts because they've inherited a bad gene, but all those things that I've listed, it's not just one of those, it's the combinations and they're each unique for each patient. That's only one small still piece of the puzzle because according to the National Cancer Institute, up to 10% of all cancers may be inherited genetically. So that's very few. I think it's even maybe 2 to 7%. That means that the overwhelming majority is simply not due to genetics. It's due to epigenetics. These are changes that happen in our life that affect our immune system, our mitochondria, our toxins, infections. These all impact the epigenetic changes that are caused by environmental exposures, aging, inflammation. Yes, poor diet and lifestyle. I'm not recommending you eat sugar. This leads to a multitude of factors, including immune breakdown, and more so as we age if we don't take care of ourselves. That's epigenetics. It changes our expression over time. Epigenetic means your genes are not just fixed instruction, they're responsive. That means you can change them. That's the exciting part. And they respond to things like diet, lifestyle, exercise is huge, sleep, rest, stress, food toxins, infection, metabolic flexibility, more than just blood sugar, mitochondrial damage, immune signaling. And this changes the terrain of our body. That means the question is not only what genes did you inherit? Yes, some people have BRCA breast cancer, other genes they inherit, but that's not the majority of people. The bigger question is what are the environmental telltale signs, things that you're doing every day? Maybe you're already eating well and exercising. You think you have everything covered. And that's when I'm saying you need to look a little deeper because cancer's usually not just one bad moment. It's a series of things that happen over time. Cancer's often years in the making. Biological pressures, inflammation, oxidative stress, unknown infections, immune distractions, toxins, mitochondrial stress, poor membrane repair, and your body's whispering way before the cancer screams and comes out. We need to make these changes. So if you're working with a great functional medicine doctor, you can do a lot of this work. You can really get into great detail. And that's one of the things a lot of people are missing. They're not looking that deep to prevent the disease. Even during treatment, these are the things you want to correct. For long-term remission. So this is where standard medicine misses the bigger picture. Standard oncology is mainly built around basic markers, National Comprehensive Cancer Network guidelines like tumor markers, biopsy, imaging, maybe 24 markers and a scan, and then you're building a treatment plan. And that works for the averages because remember, that's not personalized or precision care. We look at over 1,000 markers. So we even find that people are on the wrong chemo, they're on the wrong immunotherapies, PD-1 inhibitor isn't going to work that well. So we're learning that we have the data, we have the information, but why isn't it being used with the patient? Because the cancer industrial complex is not designed to utilize this information because it's really built by a big pharma, big hospital, big insurance billing system model, which all the hospitals and major cancer institutes use to treat people. So it's the fundamentals— chemo, surgery, and radiation. And though those can be helpful, they have to be targeted. And so most people have very little targeting, if any at all. Basically, they're using the standard of care, which was built on a double-blind placebo clinical trial, not you. The difference of N of 1, which is precision oncology, it's built directly on you because we can tell from the whole story of the patient with deep 1,000+ markers, RNA transcriptomics, DNA mutations, immune spatial biology, immune profiling, 1,000+ markers. We can now see where the smoke is, exactly where the targets are, take the guesswork out and be very precise with treatment so you don't have the same side effects, better quality of life, and better response. That's the promise of precision oncology. Even when you're talking about dietary supplements or those causative factors I just listed, we can break those down and fix those with diet, lifestyle, nutrients, biohacking, right down to the point where the patients have the best chance of responding. So if you already have cancer, you need to ask bigger questions, not just what cancer do I have, but what is my body doing to allow this cancer to form? What are the right targets to treating my cancer? Not just a one-size-fits-all modeling that's used right now, but a detailed testing that's showing you what your cancer's doing, what are the right drivers to treating your cancer, What would be the right immunotherapy? And then be able to model this to predict the outcome. See, that's what the future of oncology is able to do in precision is predict the outcome with the datasets so we can improve on those and monitor in real time the response. You don't have to wait for imaging later or some tumor marker. You're gonna see if the treatment is working right away. You can find the hidden drivers or causative factors like infections, chemical toxins, heavy metals, or depending on the patient, you need to do the testing to find these things because these things play an important role to the growth and spread of the cancer., and it takes a detailed analysis of looking at these changes that need to be made. Is there fungal overgrowth, parasitic exposure, dental infections causing immune weakness, gut microbiome issues, you know, infections like H. pylori, which can cause gastrointestinal cancer, chronic sinus infections, mold exposures, mycotoxins. See, these aren't just a number of things that I'm naming. These are things that are directly related to your body's immune system and your ability to fight cancer. That's completely overlooked by standard oncology. Why is it so important? Because it ultimately impacts your immune system, and your immune system is your first and last defense against cancer. And if we want our immune system to respond and we want to shut down our chronic inflammation, this is gonna have a massive response to our cancer outcome. And that's what a lot of people are missing. Almost never are patients looking at these factors in great detail. They'll focus only on maybe imaging, biopsy, and tumor markers, which are okay to give you a basic treatment plan, but no one's asking the deeper question. Am I on the right chemo? Am I on the right immunotherapy? Is it being delivered correctly for me? We find that over 90% of the patients we see are on the wrong chemotherapy. And what are the drivers? Does this patient have mold exposure or immune dysfunction that no one's ever diagnosed? Because they may be great runners and ate well and were healthy, but they were missing this deeper diagnosis, this hidden viral load, if you will, that might be driving this immune system problem, or a dysfunction in the gut lining. No one's asking these deeper questions, and by not asking them, we're not doing the best by our patients, right? That's how we can really change patient care. This is one of the biggest blind spots in in care because it's like, why do we need to bother with these things? Let's treat the cancer and we'll see in a few months and see if it comes back. And we're missing this deeper analysis which can change your response to care long-term. How many times we've heard somebody get cancer and they get like a 30, 40% shrinkage and then the tumors come back and they're even more resistant and difficult to kill. We never asked the question, why weren't their natural killer cells targeted correctly? Why didn't we get rid of the driving factors to their cancer? Maybe an infection or issues that were wrong. And so these are the deeper questions to hold those responses and to hold remissions long-term so we can, dare say, help people live long with a high quality of life without the cancer coming back. That has a lot to do with understanding the full body's response to cancer. So when you ask these questions, you're gonna get better responses. We need to pick up the fingerprints of the cancer that are in the body, the terrain, if you will, the crime scene. We need to see the full immune system, natural killer cells, dendritic cells, or custom designed treatment to stimulate the proper immune system. This goes way beyond a basic, let's PD-1 inhibitor immunotherapy your doctor's prescribing for you, because that may only work short term. In fact, the data shows us that it maybe works 10 to 12 months if you're a candidate. So we want immunotherapies that work a lot longer than that. And so we can custom develop those. We want to remove the toxins and infections and causative agents that are leading to immune weakness, inflammation, and hence pushing the growth of the cancer. We want to fix mitochondrial health, which is the energy of your body. It's where the apoptosis takes place, that p53 breakdown of the cancer. We want to fix mitochondrial dysfunction. Membrane health, and all that can be done with diet, lifestyle, good immunity. And that's the key to having strong protective anti-cancer responses for patients. And it should be right built into your care. So when you're working in precision oncology, you're looking at all of this information. You're not just simply looking at a tumor marker, imaging, and biopsy. And that's the difference. It gives us a lot more information because we see the immune system is not just a secondary thing. It's the main thing. We want chemotherapy and its treatment to be cytotoxic, killing the cancer, and not just cytostatic, managing the cancer. The natural killer cells, for instance, are on the front line. So if we have a broken tumor microenvironment that's suppressing your immune system from getting to the cancer, we need to fix that before we even build an immunotherapy program. See, these are the right questions we want to ask the doctors when we're getting treatment. How do we strengthen my immune system? What are we doing for my immune system to attack the cancer? How can we combine all the treatments so I have intelligent immunity and the right targets? What targets are we using to treat the cancer? Are we using DNA, RNA, immune profiling, immune spatial biology? Are we using making a decision to treat the cancer? Because if we're not, we're really missing the boat. And that's what I want to teach you is those are the questions. Are we tracking my inflammation? Are we tracking my immune suppression or surveillance? These are the questions we want to ask our oncologists. And if the answer is, well, I don't know, maybe you need a new doctor. You want to know what your microbiome health is. You want to know what the signaling is to your cancer and the terrain, because that's going to change the entire picture of the disease. And that's what years of experience have taught us in our work. I mean, we have like 400 people on our team and well over 60 physicians, and the whole team sees this. Over and over again where patients are ill-equipped. They don't have the detailed testing and they don't have a detailed plan to hopefully get in remission and hold remission. It's just not being done in standard oncology, and that's where precision oncology can help patients move from fear, unknown questions and answers, to getting a detailed plan that's like a fingerprint specific for the patient, getting rid of the hidden drivers, improving the mitochondrial health, restoring the patient's energy, and responding to healing Getting rid of oxidative stress and improve immune signaling, regulating cell death, knowing what our targets are for your specific cancer and mutations. That's the questions that we should be asking the doctors so that we know the care that's being given and we're not just guessing because right now there's a lot of guesswork happening through the National Comprehensive Cancer Network guidelines and it works for some and not for others. That's where precision oncology can help with repairing the system, getting to the root cause, improving things like insulin sensitivity, inflammation drivers. This is why I tell patients you can't separate the cancer from the patient's total health and causes. They work together. A weak cell isn't resilient. It doesn't return to health. So if you're weakening the whole body with chemotherapy, for example, maximum therapeutic dose, which is done in standard oncology, you're weakening all of the cells of the body. You're damaging the mitochondria and the patients are fatigued, losing their hair. That doesn't need to happen. When you have the right targets, you can microdose and keep your strong immune system and have good health. And we need to deal with the stressing influencers like inflammation, immunity, insulin insensitivity, detoxification, and combine these into deeper layers of care that are customized for each patient. See, that's how we strengthen the healthy cells of the body and remove the ones that need to be taken out with an intelligent approach. So that's what I really want to encourage you today is to see the body and how it's being affected and to get to the root cause so that you're getting better care and a better detailed plan. Think of your body or your cell membranes like an antenna on a radio. Back in the old days, there's a signal that may be out there and quite a few signals that are interrupting your cell's messaging, your body's health, your hormone signaling, immunity, nutrient, enzymatic pathways. It can go on. We can tune these in, we're going to always have better response to care. And if we can tune the treatment in so that we can disrupt the signal of the cancer with the precision targets, it changes the entire outcome for patients. That's the promise of precision oncology and why it's so important that patients have access to this, and it's not a second thought, because now they can combine the best of diet and lifestyle and targeting and immune targeting and put it all together to get the best responses that patients deserve. We can't expect the body to run with a high level immunity and repair and basically eradicating the cancer if the basic architecture is broken. So we need to look at it in great detail. So I hope this episode helped you look at the secret cause of cancer, right? It's not one thing, it's the right combinations that are needed to bring healing to your body or help you keep and maintain prevention, or keep and maintain remission, or get into remission. We need to know what those drivers are so that we can help patients restore to total health. I hope you found this episode helpful, and may the Lord bless you on your journey to healing.
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