Dr. Jeffrey Gladden breaks hyperbaric oxygen therapy into four mechanisms: mechanical (reducing swelling), immunological (fighting infection), metabolic (boosting mitochondrial energy), and regenerative (tissue repair and collagen). He shows how to stack HBOT with fasting, NAD+, peptides, and red-light therapy to amplify results for specific clinical goals.
if you broke down the mechanisms of action into like 4 categories, mechanical from like a vasoconstrictive swelling edema management, immunological from killing anaerobic infections through upregulating the immune system's ability to fight infection, and then metabolic, the whole like energy production side of all the mitochondrial benefits, and then regenerative, all the, all the healing mechanisms, the, the VEGF, the BDNF, right? All these growth factors that stimulate tissue healing and repair, and then stem cell mobilization, collagen formation, all of those things. So if whatever it is you're trying to solve for fits into one of those 4 categories, it's like, okay, mitochondrial, okay, so here's the hyperbaric program for that. But what else can we do? Well, fasting is good for the mitochondria. NAD could be good for the mitochondria. CoQ10 could be good for them. You know, red light's good for the mitochondria. So you can create a stack based on a goal, right? Tissue repair, which peptides could we use for, you know, GHK-CU and, you know, shockwave therapy mixed with hyperbaric. So we pick a goal, like what role does hyperbaric play in it? And then what are the targeted therapies that we can add to it to create that synergy? That's, that's usually how I kind of take a patient through the thought process.
