Dr. Jeffrey Gladden argues that standard thyroid blood tests miss dysfunction without measuring resting metabolic rate and checking the DIO2 gene, which controls T4-to-T3 conversion in the brain. He dismisses the claim that gut methylation drives this conversion and says clinicians need blood work, metabolic testing, and genetics together for accurate diagnosis.
We find biometric testing, you know, to be incredibly useful. For example, when it comes to thyroid, we find thyroid misdiagnosed all the time.
Yeah.
Because people are looking at blood tests. It's like, well, your T IS station is normal. You know, your T3 looks okay. You know, all that, and it's like it might even be optimal. What we find is that if you don't know the resting metabolic rate, you know, you don't really know where they're at systemically. And if you don't know their genetics for their DIO2 gene, about how they convert inactive T4 to T3 in the brain, you're missing another massive piece. Right. So it's. And then you got
talking heads out there that are saying T4 to T3 is. Is a methylation pathway and it happens in the gut. I don't know if we want to drop names, but
yeah, I mean, these people are just lying. It's crazy. Exactly. The gut will impact stuff. But I'll tell you, I originally tried using T3 T4 ratios, and I'm very quickly got very disenchanted with it. But we find resting metabolic rates to be super, super helpful. So that and genetics as well. The point being that if you're listening to this is that you want to be working with somebody that can give you really precision, and that means that they have the understanding capability to actually look at you through multiple lenses, to actually get your stuff to come into focus. Otherwise it's going to be blurry and you're going to make mistakes.
