https://www.youtube.com/watch?v=8twnNVQ8qiY

Welcome to the Gladden longevity podcast with Dr. Jeffrey Gladden, where our passion is helping you to become an AJ hacker. On this show, we want to help you optimize your life energy, longevity, health and human performance with impactful and actionable information by answering four questions. How good can we be? How do we make 100 the new 30? How do we live well beyond 120? And how do we live young for a lifetime? Now here's today's episode of the Gladden longevity podcast.

Hey, Dr. Jeffrey Gladden here. I just want to let you know I just had a really great conversation with Steve Reiter, who has been a co host in the past here on the Glad Longevity Podcast. We're talking about Men's Health Awareness Month and had a really fascinating conversation I think you're really going to love about optimizing male health. So enjoy that.

Welcome to the Gladden longevity podcast with Dr. Jeffrey Gladden, where our passion is helping you become an age hacker. On this show, we want to help you optimize your life energy, longevity, health and human performance with impactful and actionable information by answering four questions. How good can we be? How do we make 100 the new 30? How do we live well beyond 120? And how do we live young for a lifetime? I'm Steve Reiter, back for another monthly Q and A, which our schedules didn't exactly match up for the last month, maybe even two. I don't remember was. I remember the last one that we did, but. Dr. Gladden, it is glad to be on a call with you again.

Yeah, yeah. It's good to see you again, Steve. Yeah, really great.

How's your summer been?

It's been active. It's been really good. It's just. It's kind of been amazing. You know, I got hurt last August and then had to rebuild my knee with three regenerative injections that we did here. And then I got to a point where this spring I was able to start running again and biking again. And now I've been doing a process to really boost NAD levels for myself, and energy levels are just off the charts.

Like, so what, what, what are you doing for building up the nad?

Well, it's. It's really a combination of taking several supplements. Nucito Thyme, which is a really well constructed NAD supplement in that it supports NAD in the cell through several different mechanisms. It blocks the breakdown of nad, it increases the recycling of nad, both of which go haywire as we age. We tend to have CD38, which breaks down NAD and is the highest affinity for NAD. And the NAMPT enzyme that recycles, it also gets weaker. So it addresses both those issues, then supplies some niacin as a precursor for nad. And that works well. But then we couple it with. It also has some apigenin in it to block the CD38. Then we couple that with new. With the vitality. And vitality has different elements in it, has some nmn, has some D ribose.

Is it a capsule?

Is it's a cap, it's a wafer or a powder. The nuchito is actually six capsules. We just had a call with them. They're actually figured out a way to condense it down into three capsules for the same dose. So that's coming soon. But combining those two is helpful. But I will say that in using either one, either alone or together, I would notice a bit of a boost, but not the way we are now. Because what we're doing now is we're combining it with an ozone sauna. So what we'll do is we'll jump in the ozone sauna, we'll have taken the supplements, jump in the ozone sauna. And what the ozone does is it. It basically oxidizes nadh. NAD actually, basically is in two forms in your cells. NAD the oxidized and nadh the reduced form. And it goes back and forth between those two. So when you expose yourself to ozone in a sauna, you're actually oxidizing more of the NADH back to nad. And we talk about NAD all the time, but it's really the ratio of NAD to NADH that's so critical. So when you have the precursors to make NAD and protect the recycling of NAD and block the degradation of nad, and now you're oxidizing NAD th back to NAD to change that ratio in a favorable way. Oh, my gosh, you are. You are literally 18 again. It's like I go out and I hammer these rides on my mountain bike or whatever. It's just nuts. And if you want to. If you really want to get serious, you do plasmapheresis, which I'm also stacking in about every three weeks now. And then you do that after the plasmapheresis and the effects will last. Seems like it lasts for. For weeks. You know, I'm doing the. The ozone sauna now twice a week, just in general this way, but. And the effects of what I've talked about with the ozone sauna and the supplements, and then taking the supplements daily afterwards, that effect will last for three, four, five, Six days kind of thing, maybe, but with coupling with plasmapheresis, it's a couple weeks, two and a half weeks, something like that. So anyway, the point is that you need NAD not only for energy production, but for cellular repair. And so when you're combining all of this energy now with anything you want to rebuild, whether it's your knee, your brain, relengthening your telomeres, increasing autophagy with, you know, with spermidine, which has now been shown to be one of the most powerful longevity supplements you can possibly take. You know, you really, you really sort of start to turbocharge this whole system. We can do a lot of great things from a longevity perspective, but if the, if the system is being bogged down by low energy and high levels of inflammation, it's very difficult to, to actually, you know, get the thing going in the right direction. Right. You're just kind of struggling with low energy production and a lot of inflammation. So the plasmapheresis, you know, if you use senolytics before the plasma freesis like we do, and then you, to kill the senescen cells, and then you do the plasma freesis, you really clear out all the inflammation now you're boosting the energy production. So now you've actually put yourself back into a very youthful scenario where there's lower levels of inflammation, much higher levels of energy. The body can do what it's supposed to do in terms of healing, repairing, and, you know, the fun of life. Right. Which is doing whatever activity you enjoy most. So that's fun. Yeah.

Well, a number of those supplements that you mentioned are available at the, yeah.

They'Re all in the Glidemore delivery shop. That's right. All of them are in there because we believe in them, and we believe in them because we've been using them and seeing how we can make them work.

So, you know, I'd love one of these times for you to bring like in a dish, your daily supplement routine. So that way, that way listeners could go to YouTube or go to Facebook and see the amount of supplements that you take on a daily basis.

Yeah, it's always in flux. Right. So I, I, the, the idea is, I mean, there are some people that are taking 150 pills a day. That's never been my, you know, there's no, there's no trophies being handled, handed out for how many supplements you can take. Right. I think too many supplements is, it can be bad, it can be, it can be stressful on the body to try to assimilate all that stuff. Right. So I try to do it as elegantly as possible. And one of the. One of the. And maybe on the next one, I will kind of go through what I'm doing. But to give people an idea, the way that I go about it is I space it out. So I get up and I take my thyroid in the morning. You know, I do my. My meditation, my journaling, and things like that. I do my workout, come to the office, and then I'll take. I won't have eaten anything I like. I'm now taking spermidine in the morning because, you know, I'm already fasting. Exercise itself will induce autophagy if it's not weight training. Right. Like cardio will help induce autophagy. And then I take the spermidine to kind of boost it even further. But the thing about spermidine is it actually works on virtually every hallmark of aging. It's not just autophagy. And so that's really, really exciting. So you do that. Then I take my AM supplements, and then I will probably have something to drink in the morning, usually with some powders in it, some fiber, some protein, things like that. And then I'll eat lunch, and when at lunch, I'll take my noon supplements. And I have some things that I take at a meal. I had my gallbladder taken out over 10 years ago, so I need to take some digestive things to compensate for that. So I do that. And I also, at that point, I'm taking things that actually rebuild the glycocalyx in the. In the arteries, which is the key for arterial health. So we have a new way to measure that in the office and a new supplement. Yeah, so we. We like the glycocalyx pro that we have. A lot of it comes from an algae and builds. Rebuilds the glycocalyx. We did a study on it here in the office that demonstrated that. And we're adding to it now a new supplement called Rivaska, which is building the glycocalyx through a second mechanism so they complement each other. And so I do that at mealtime because it's at mealtime that you're actually destroying your arteries. It's not. That's really when. When we're. When we're breaking down the arteries is while we're eating. So when you're rebuilding the glycocalyx in the context of a meal, then you're kind of preserving your arterial function. And so that works out really well. And then I'll take, you know, some Supplements at dinner, and then I take some before bedtime. So I kind of spread it out is what I do. And even the bedtime supplements, I may take some and go to bed, and then if I get up to go to the bathroom, which I do once a night, I'll take the rest of them. So I'm never like, trying to take. It's not how many pills can I take? Right. So spacing it out like that and combining it with food and stuff like that seems to make it work pretty well.

One of the things that I've absolutely taken away from this time that I've spent around you on the podcast is how you will cycle supplements in and out. So you'll intentionally be spending a little more time on reduced, not adding testosterone, but really kind of focusing on, you know, the longevity. And then there are times where you'll be a little more anabolic, if you will, in terms of cranking up that testosterone, doing these kinds of cycles between muscle growth and really kind of trying to kick up autophagy to another level.

Yeah, that's exactly right. I think, you know, economies or the biology is an economy of balance. Right. So it's really about cycling in and out of these various states. You can't be building all the time or you die sooner. That's been shown over and over again. Power athletes die sooner. Everybody wants to talk about muscle as a currency of longevity. Well, if that were the case, bodybuilders and power athletes would live longer, but they die 10 years sooner. So. And I don't know if you just saw the data on the carnivore diet, but now that's been debunked as completely we've always known. Yeah, it's. It's. Yeah, it's. It doesn't make sense. You're getting all this protein, which is a massive strain on your kidneys, and all this methionine, which basically ages you. It's really not a healthy diet. Now, there are some people that benefit from it. There clearly are there. And there are people that just don't get along with plants and all that. And I get that. And, you know, God bless everyone. Diet is very, very individualized. But to just kind of generally adopt that as, you know, you know, a high saturated fat diet, and I mean, higher risk is a colon cancer. I mean, there's just a lot to not be excited about, about meat, eating meat all the time. Right. So anyway, that's. That's kind of interesting.

So this month, it is June Men's health Month.

Go, boys.

And we've. We've got the male longevity blueprint. So from your perspective, what are the most underestimated health risks men face as they age?

Not ejaculating often enough.

Oh, talk about that.

I think it's one of the. I won't make a comment. So the. Somebody just walked across Steve's desk. Anyway, yes.

My. My office has become a foster room. I'm fostering. I'm back to fostering cats for a local cat rescue organization. And my pregnant mama to be. Just walked by. Her tail just walked by.

Yeah. So I think that from the standpoint of prostate health, you know, men are at risk for prostate cancer, and the longer we live, the higher the risk is. And, and people talk about if you live long enough, you're going to get prostate cancer. We hope that that's not the case. But we do see quite a few men that have developed prostate cancer. And number one, it's important to know what your genetics are around that. Right. So in my case, I actually have a gene where excess androgens, testosterone, and things can increase the risk of prostate cancer. For me, there's no history of prostate cancer in my family, but knowing that there are things that I do that are pretty meticulous around taking care of the prostate. So I don't want to stay away from testosterone because I like a lot of the benefits. Bone density, muscle mass, general resilience, robustness. You know, libido comes on board. So all that's. All that's for the good. And yet I work to protect my prostate by doing things. Taking diandyl methane to help me metabolize the testosterone down the safest pathways. I do things with Genistein, which basically is a estrogen agonist. I don't want to basically knock down estrogen. I think one of the big mistakes that men make is getting on testosterone and trying to block estrogen production. Men need estrogen just as much as women need testosterone. And it's super healthy for your brain and your heart and your blood vessels, and it's actually better for your prostate. But you got to have the right metabolites coming through these hormonal pathways. When the hormones go in, your body's going to metabolize them to eventually, you know, break them down and get rid of them. It happens, you know, with everything, but you want to make sure they're going down the right pathways. And without knowing your genetics and then measuring how you're actually metabolizing it, I think that's a big hidden risk. So I would really Encourage people to get, you know, a test that looks at hormone metabolites. There are a couple of them out there now, the Dutch test a lot of people have heard about. And now there's a vibrant hormone zoomer that does a really great job of looking at this also. And you also want to get blood levels, so you need blood levels. And the problem with most T clinics is they're getting blood levels, but that's all they're testing. They have no idea what the metabolites are doing, which means you don't have really any idea how much risk you're putting your prostate at. And since people don't know their genetics, they don't really know if it's a risk to them in the first place or not. So you can see you're kind of playing with fire when you want to be not playing with fire. You want to be, you know, doing good things. So all that's super important. But it's been shown that men that have over 20 ejaculations a month have a significantly lower incidence of prostate cancer. And so it's really, really important. I think a lot of men, as they go through life, they get in relationships or they're not in relationships, and relationships can, you know, the flame can sort of die or whatever it is, you know, And a lot of people end up in lower sex activity, relationships or situations than they would like to be, but they kind of acquiesce to it. And I think it actually represents a big health risk for men. It's not only mental health, because I think men feel better when we're able to be sexually active. It's. It's a beautiful thing. It's not a physical act. It's really a psycho spiritual connection with an individual. Right? And so having that really sweet connection that's very nurturing and loving and giving and receiving and, you know, all the above is incredibly salutary for us, right? And it really releases a lot of oxytocin. And oxytocin is a molecule that has a massive number of longevity benefits also. So we're built for emotional closeness and sexual activity. And then ejaculations are incredibly helpful for protecting the prostate. So I think a lot of men, even men that are interested in longevity, have kind of acquiesced to the fact that they're just not going to have as much sexual activity as they did when they were 18. And yet they should be. They actually should be, one way or another, right? They should be having activity. So I think that's. That's really, really important to understand. And then when you think about that, well, what is it? What does it take? Well, you need to have libido, right? So having some DHEA on board, having testosterone on board, those are things that push libido. Dihydrotestosterone. You need some of that, but not too much, because that bothers your prostate. Also can enlarge. It can increase the risk of prostate cancer. So, again, you've got to get everything just right. But. But when you do that, you know, and your libido comes up, then you find yourself in a position, but then you've got to have vascular function to support that. So this is where the glycocalyx is so important. The real. The real root cause of cardiovascular disease is a destruction of the glycocalyx. And if you're not familiar with what it is, it's kind of like the fuzz that grows on the bottom of a river. So if you imagine your artery like a pipe, and the outside of the pipe is fairly tough, that's the adventitia, that's the fibrous tissue that kind of holds it in together, if you will. It's like if you were to run over your hose with a lawnmower and it had a tough outer coating, you wouldn't really cut it. So that's the piece. And then inside that is a muscle layer which can either constrict to narrow the artery or relax to expand the artery.

Right?

And if you're having sexual function or sexual activity, you need to actually have that relax the muscle, relax to allow blood flow to go into the genital area. And same for women. And so if the glycocalyx, which is this fuzz now that grows on the inner lining of the. Of the hose, right? It's kind of is a. Think of it as a sensory organ for blood flow. So as blood flows by, the glycocalyx is kind of waving in that breeze of that water flowing by, and it signals the artery that, hey, blood flow is increasing. We need to increase nitric oxide production. So it signals the lining of the artery, the skin that lines the artery, the endothelium, to produce nitric oxide. So having a healthy glycocalyx is critical, but then having the ability to back it up with the ability to make nitric oxide. So you have the healthy glycocalyx with the glycocalyx proxy and the revasca. Those two supplements together are magical because they're one.