Dr. Jeffrey GladdenFounder & CEO of Gladden Longevity

The Power of CCK

12 May 2026 · 1 min

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In this brief conversation, Speaker A highlights that cholecystokinin (CCK) not only acts as a potent appetite suppressant but also actively stimulates the gallbladder to contract, increasing bile production. They contrast this with injectable weight‑loss therapies, which can lead to gallbladder stasis and reduced bile flow. Dr. Jeffrey Gladden expands on why a functioning gallbladder is essential, explaining its partnership with the pancreas to emulsify dietary fats and facilitate the absorption of fat‑soluble nutrients such as fish oil, vitamins D, A, E, and K. The dialogue underscores the importance of preserving gallbladder activity when using appetite‑modulating agents.

Chapters

I think the important thing with CCK, remember CCK, and that's why gastroenterologists love it, uh, squeeze the, um, the gallbladder. Yeah. So you are producing more bile with it. Uh, and I, you know, with the injectables, you often get a stasis, uh, of the gallbladder or the gallbladder doesn't squeeze. So certainly with these, with the CCK, um, it's not only a very potent appetite suppressor, Uh, but it also does express the gallbladder.
Yeah, no, that's great. And that's really important because you need the gallbladder in conjunction with the pancreas, but you need the gallbladder to emulsify the healthy fats that you want to absorb, whether it's the fish oil or the vitamin E or, you know, whatever it is you're trying to take in vitamin D for that matter, vitamin A, vitamin K. So it's very important that the gallbladder is working. It's really part of the whole nutritional cycle.