Dr. Jeffrey Gladden explains that hormone replacement therapy works best when hormones are balanced, not maximized. The goal is optimizing growth hormone, testosterone, estrogen, and others together to strengthen bones, build muscle, and sharpen cognition. Poor results usually mean the regimen wasn't personalized enough.
Hormone replacement is probably, probably one of the earliest forms of quote unquote functional slash longevity medicine when people realize that they could feel better if they had hormones put back in. And what we've discovered also is that growth hormone is very important—not too much and not too little—but being able to boost growth hormone. We don't really give growth hormone, but it's really the balance of all those hormones: growth hormone, IGF-1, testosterone, estrogen, progesterone, DHEA, the metabolites. When you get that all dialed in, people can feel remarkable. You can feel amazing. You can have bone density and muscle strength and a clear brain and lots of energy and things like that. But if you're doing hormone replacement therapy and you're not getting where you want to go, chances are it hasn't been looked at thoroughly enough to actually understand how to make it work for you. So I'll just point that out.
