Keeping Abreast Episode 77: Understanding Reproductive Health Signs with Jessica Preston

6 Jan 2025 · 78 min
1:18:16

A Keeping Abreast episode (Jan 6, 2025) featuring Jenn Simmons, MD and Jessica Preston exploring fertility as an early marker of systemic health. Key points: one-in-five infertility prevalence (≈19%); menstrual-cycle signs to watch (ideal ~28 days; concern if <27 or >32, heavy or very scant flow, debilitating cramps); common tests discussed: sex hormones (estrogen metabolites, progesterone, testosterone, FSH, LH, AMH), thyroid panel (TSH, free T3/T4, rT3), fasting insulin/A1c, inflammatory markers (CRP, SED rate), prolactin, cortisol rhythm (saliva/5-point), vitamin D, liver/kidney function, genetic SNPs (e.g., COMT, SLC6A4) and microbiome. Functional-medicine viewpoint: AMH can be improved with interventions (Jessica reports rises within ~90 days), TSH ideal ~1, mast cell activation prevalence mentioned (~30%), male-factor infertility ~40%, and ~55% of infertility falls into a broad/unknown hormonal/lifestyle-driven category. Interventions prioritize nervous-system regulation (biofeedback, breathwork, hypnotherapy), nutrition, sleep, relationships/coaching, toxin reduction, and targeted supplements; coaching programs and a year-of-the-healthy-baby campaign (6-week automated program) were promoted.

Questions this video answers

About 19% (they phrase it as ~1 in 5; also referenced 1 in 4/1 in 5).

Around 28 days; concern raised if under ~27 days or over ~32 days (ovulation ideally ~day 14).

TSH as close to 1.0 as possible; concern above 2.0 triggers action.

She reports seeing improvement within about 90 days.

Approximately 30% of people.

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