Dr. Preema VigClinic Owner & Medical Director, Dr Preema London Clinic · Medical Director | 20+ years of experience performing injectable treatments

What Are Polynucleotides? Dr Preema Explains Skin & Under-Eye Treatment

29 Sept 2026 · 2 min

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2:05

In this video Dr. Preema Vig explains the use of polynucleotides—highly purified DNA fragments derived from trout—as an injectable regenerative treatment aimed at improving skin quality rather than adding volume. She describes how these DNA fragments support the skin’s natural repair processes, enhancing hydration, elasticity, texture, and reducing fine lines. The doctor emphasizes the particular suitability of polynucleotides for the delicate under‑eye area, where skin quality issues often masquerade as tiredness or fine lines, and clarifies that the goal is not to fill or reshape but to rejuvenate the skin itself. Dr. Vig differentiates polynucleotides from hyaluronic‑acid skin boosters and traditional dermal fillers, noting that each serves a distinct purpose. Finally, she outlines the assessment‑first philosophy at her Dr. Preema London Clinic in Mayfair, where treatment decisions are based on a thorough evaluation of the patient’s skin, facial anatomy, and underlying concerns rather than a one‑size‑fits‑all approach.

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Polynucleotides are something we are using more and more in clinic, particularly when we're looking at improving skin quality rather than adding volume. They are an injectable regenerative treatment, and the polynucleotides we use are derived from highly purified trout DNA. Essentially, we're using these DNA fragments to support the skin's own repair processes and help improve things like hydration, elasticity, texture, and fine lines. One of my favorite areas to use polynucleotides is around the eyes. The skin here is incredibly delicate, and when someone comes to see me saying their eyes look tired, or they're noticing fine lines or that slightly crepey texture, my first thought isn't automatically, you need filler. Sometimes there is a loss of volume and filler may be appropriate, But very often what we're actually looking at is the quality of the skin, and that's where polynucleotides can be really useful. We're not trying to fill or change the shape of the eye area. We are looking to improve the condition of the skin itself, which for me fits very naturally with the way aesthetic medicine is moving towards regenerative treatments and more natural-looking results. And polynucleotides aren't only for the under eyes. We can use them elsewhere on the face and neck where skin quality is the concern. They are also quite often described as a skin booster, but I think it's important to understand that polynucleotides, hyaluronic acid skin boosters, and dermal fillers are different treatments and they do different jobs. At Dr. Preema London Clinic in Mayfair, we don't start with the treatment. We start by looking at your skin, your facial anatomy, and what is actually causing the concern, because ultimately it's not about whether polynucleotides are a good treatment, it's about whether they're the right treatment for you.