Dr. Tabatha Barber explains how hormone pellets deliver a high initial dose that creates a supraphysiologic hormone level, then slowly release hormone over about three to four months before levels fall sharply. She notes patient experiences vary: some women feel dramatically better soon after insertion but may worsen when levels decline months later.
Hormone pellets are a pretty hefty dose. You often get a supraphysiologic response, meaning your levels are going to be higher than any normal range that you would shoot for in a normal situation, because the pellet gets put in and it goes to this high level, and it gets slowly released every single day until it wears off three to four months later and the levels drop down really low again. Some women tolerate it well and they feel amazing, like they get their pellet and two weeks later, they're on top of the world. They're super productive. They're doing all the things they're like, life is awesome. This is fabulous. And then three months later, they're in the toilet and they don't want to function. And so it can be that dramatic.
