Unlocking the Secrets to Skin Longevity | A Solution for Crepey Skin

Real quick, before we dive into this episode, I have a little sleep secret I want to tell you about. Look, sleep is crucial for your fitness, but it's crucial for just plain old everyday life and function. And I find I sleep great unless I have a migraine. And I've had more than my fair share since perimenopause all the way through postmenopause. My secret weapon was Blue Sky CBD sleep gels. Each gel contains 25mg of CBD and 25mg CBN for deep restorative sleep. Something about it helps to reduce inflammation, which I believe for me was key in helping me get to sleep. But the biggest thing is so many of the over-the-counter solutions, whether for sleep or migraines, can ruin gut health, and liver health. Neither one of those did I want to be problematic for me. So this option is recommended by healthcare providers worldwide and backed by thousands of happy customers, many of whom come from our Flipping 50 community. There is zero THC, so it's non-habit-forming. It's made by a trusted family-owned company that we all can feel good about. Third-party tested for purity and potency. And if you're interested, you too can try a sample for just $6. But even better, you can get 30% off forever with discount code FLIPPING50. That's FLIPPING50. Just go to flipping50.com/blueskycbd. We'll put that link in the show notes and you'll find it everywhere on Flipping 50 at My Favorites. What are you waiting for? Good night. You lift the weights, you drop the collagen in your coffee, and you hydrate like it's your job, but still, with the toned muscles, you see loose skin. A female scientist may have the answer for crepey skin. In 2018, I received hundreds of applications for the Flipping 50 TV show, an internet-based show. Don't get confused, it was not actually on TV. And we'll link to the episodes here, by the way. Popular questions made it to the show. That's how I vetted them. The 18th episode of the 39 done over 3 seasons was literally about this very topic— creepy skin. In the letter, it was from a woman who'd experienced significant weight loss, and yet her loose skin was an issue, and she's not alone. Even without weight loss, at some moment post-menopause when that estrogen needle bonks, almost all women notice a difference in their skin quality. But some seem to have it figured out. Not all women over 60 or 65 or 70 have the same skin. So what's the difference? Lifestyle habits do matter, and for secret weapons, this episode shares a relatively new discovery. In this engaging podcast episode, Dr. Alessandra, the co-founder and chief scientific officer of OneSkin, dives deep into the world of skin longevity. Now, You can take this as superficial as you want to, and trust me, I can be superficial. Can't you? I mean, when you look in the mirror and you're like, oh, that's not what I had in mind today. But it is also more about that. It's about health, and you'll hear us talk just a little bit more about that. My guest again is Dr. Alessandra Zanari. She's the co-founder and chief scientific officer of OneSkin. It's a disruptive and fast-growing longevity company developing products to address the root causes of aging so that skin functions, feels, and appears younger. Now, before we dive into, you know, crepey skin on your neck or décolleté, which I don't know about you, but maybe the egotistical side of me first goes to, don't ever forget your skin is your largest external organ and your first barrier against immunity. Okay, sermon over. The company OneSkin was founded by a team of 4 female PhD-level longevity scientists with 15 or more years of experience in stem cell biology, skin regeneration, aging, and bioinformatics. They started building a skin aging platform to validate products in the market. After they discovered that many anti-aging skincare products are not only ineffective— listen to this— but often accelerate the aging process— hello, this is not good— and compromise skin's health, they set a screening platform to identify new molecules that could target the root causes of skin aging. Dr. Alessandra led the team that identified the OS-1, the world's first cosmetic peptide. You put peptides in your coffee, you should probably listen to this. That reverses aging at the molecular level, showed significant improvement in skin health and appearance in 100% of users. That is rare. And according to a third-party clinical study, this was all proven. OneSkin has gained recognition from key opinion leaders in longevity science, including foremost authority in biohacking Dave Asprey, world-renowned aging research Dr. David Sinclair, and Tony Robbins. They have also been featured in many leading media outlets like CNN, Forbes, LA Weekly, and US Insider. Dr. Alessandra holds a master's degree in stem cell biology and a PhD in skin regeneration and tissue engineering. From the Federal University of Minas Gerais in Brazil. She led the OneSkin team that discovered a new molecule, OS-1, capable of reducing the skin's biological age. Dr. Alessandra is also the co-inventor of 5 patents and has published 20 peer-reviewed papers in scientific journals. And before we start this episode, I want to point out what everything I just read, and I did, really should mean to us. So I, I share a guest bio all the time, don't I? And what I want you to hear here is this is somebody who cares not just about the marketing of a product, but you're talking about somebody who's done a master's degree. That's fairly rigorous. Then a PhD. Even more rigorous, right? And, you know, in terms of discovering a new molecule and developing a product, seeing that to fruition is not for the faint of heart. And 5 patents, I mean, this is someone who cares about what they've created, discovered, identified, and now are basically nurturing into a product And I think I love the fact that this company is founded by 4 women. Now, they're all around their mid-30s. I kind of wish that we could see into the future what happens when they're around their mid-50s because they will be even more highly motivated. So I can't wait, right? And by that point, we will be— I will be, hmm, okay, I will be almost 80. Wow. Okay. But I'm guessing I'm not going to stop caring about the quality of my skin. Certainly, I hope the muscle and the bone. So let's dive into this episode. But first, I'm Debra Atkinson, and you're listening to Flipping 50, where I address your top struggles and concerns, and I share what to eat, how to move, and how to change your mindset so you can have the energy and the vitality that you want, need, and deserve in this second and better half. And look, if you're not exercising right now, I have resources for you. So number one is, how do you plan all the pieces? You most likely, if you're within earshot of this episode, are looking for muscle and bone and potentially brain health, even though we may not put it at the top of our priority list. We need balance, we need agility reaction skills so that if we are falling, we right ourselves instead of going down. And we need to have all of those pulled together in a way that is not taking up the same amount of time as a part-time job would. Exercise planning is the answer. And when I start listing The things that we need, like again, the balance, the agility or reaction skills, the strength, the power, the balance, did I mention that? The bone density, the brain health. We've gotta wonder, how do I fit all these things in? It's not nearly as hard as it might sound because within your warmup or within your agility, we can pull these things together and they will overlap. It's like beans. You're getting protein, you're getting fiber, and you're getting carbohydrates. We got 3 things there, check all the boxes and we count them all. But you need to have some kind of a plan. So I have a very specific e-guide plus a short masterclass. So you can go through the masterclass with the e-guide, use it like a worksheet and figure out, all right, here's my top priorities right now. 'Cause it may for you be bone density, maybe it's not, maybe it's lean muscle, maybe it's improving your body composition. Maybe you just realize your balance is terrible and you thought it was pretty good. There can be any number of things, but putting— okay, your top 3 and saying let's put them in order 1, 2, 3, and then looking at how do we plan your exercise so we're really catering to all the parts but really featuring those 1, 2, and 3. I walk you through exactly how to do that step by step. You will, in a sense, have a crash course in personal training and in program design. And know exactly what should happen when so that you have adequate stimulus for those things and adequate rest in between. I will put the link to that in the show notes and let's dive in. Alessandra, thank you so much for being here.

Thank you, Debra. I'm very excited to be here and to join this conversation.

And I'm so excited actually to say your name is so beautiful.

Oh, thank you.

So literally. Very fitting. All right. And before we dive into all things skin and skin quality and what impacts our skin in our— I mean, we're all going to have aging skin. There is no way out of that one. But how it will age. I want to ask, why are you doing this? I mean, of all the things you could have chosen to be when you grew up, but it was this always it. And why? Why this now?

Yes. So to give a little bit of context, I was born in Brazil and I would say when I was young, I I had no idea I would be living in San Francisco and translating my research into a skincare product. But at an early age, when I was around 10, I was already fascinated about biology. So I remember when I was 10 was the time that they cloned the first mammal that was the sheep Dolly. And I was like, oh, cloning. I was so afraid. Tell you honestly, I was so afraid of getting older or losing my parents because they would get older that I was super young. I remember I was watching the TV with my parents. And then when they showed about cloning, I was like, oh, when I grow up, I want to clone you, Daddy and Mom, so I would never lose you guys. And that's how I start to be interested in science. And then when I went to college, start studying cell biology. And I always knew that I want to do research and that I wanted that research to be translatable. So I went to a master and a PhD researching how to build organs in the lab. And during my PhD, I specialized on skin because I just realized that it's an easy organ to grow in the lab. So you can— it's less complex. Than, let's say, a heart. And then I started researching how I could build skin in the lab, use stem cells to promote wound healing. So this was— I did this research during my PhD and over 3 years of postdoc after my PhD until I get together with my 3 co-founders that they were just— Carolina was just moving to San Francisco to join an accelerator program. They were all like my colleagues from PhD. In Brazil. And we started with this idea of like reproducing the skin in the lab. But let's understand the aging process of skin and let's look— let's try to validate on this crowded market that has so many products that claims to be anti-aging. Let's try to validate if they are really promoting any type of skin rejuvenation. So I just saw myself like embrace on leading this research team here in San Francisco to dig in to skin aging. And from the beginning, when we started the company, we started to correlate skin aging with the longevity and how even like if we prevent or if we accelerate the aging process on the skin, how we can promote more overall health. There is a huge connection of our skin and our overall health. And I just got completely fascinated about the whole field of skin aging. And I just realized, okay, I'm doing really, I couldn't see myself doing anything else. And as we were doing the research and we developed this new molecule, we decided eventually one day we thought we would be licensing molecules to the market. And then we realized that our data was better than what was in the market. And we decided to bring this to the consumers as a brand, as a direct-to-consumer brand. And that day when we made that decision, this was back in 2019, I mean, my dream of translating science. So far I have been doing science for over 15 years in my life and I saw an opportunity. Okay, our science will be translated into a product. This was a dream. And we've created this brand and we have been developing this skincare routine, continue doing research. I'm still leading the research team of our company and we are bringing always like innovation on how we can like preserve the skin to help create to all of us age better.

And I love that. And I think one of the things that, you know, I will say a lot to women is, you know, we have had for a very long time when we talk about fitness, you know, we have judged the wrong thing. I mean, we often think, okay, someone thin is fit without ever knowing, you know, how strong are they? What kind of endurance do they have? You know what? What stamina. And, and yet I think one of the things that is really such a great judge of your wellness and your health is when you look in the mirror. I mean, with a naked face, you cannot fake that. You know, it's— your skin just tells all of what's under the hood. And it is ironically, or not so ironically, often with weight gain or weight loss, there are changes in the skin. And, you know, beyond, you know, increasing circulation and exercise being wonderful for that, sometimes it is weight loss that causes the most dramatic and sometimes negative effects in skin for women who are, you know, of a certain age. But before we unpack that and the crepey, loose skin that can happen at any weight, actually, even with minimal change. But what would you say are greatest contributors to skin aging when we talk about, you know, looking at women, you know, maybe 10 women who are 60 with the same, same age skin? Some of them seem much older.

Yeah, I mean, what I like— I love about science, and one fact that's very interesting because before I thought like, okay, I have my grandparents that had cancer, so I will have cancer when I get older. But now we know that like our genetics, they just contribute to 10 to 30% of how we are aging or what we will face in later ages. 70 to 90%, it's all lifestyle. So the way— the things that you're eating, if you're exercising, the quality of your sleep, all of that are influencing not only your skin aging, but your overall age. Specifically to the skin, we know that sun exposure is one of the most— the biggest drivers of skin aging. So a lot of like sun exposure without real protection can accelerate the aging process. Also, like long time with bad habits like smoking or excess of alcohol. This can cause dehydration. This can increase the free radicals on the skin. And this can also lead to an accelerated skin aging. So basically lifestyle choices, they can impact and they can make two persons that have the same chronological age have like different appearance on the skin. And what we have been doing as well is like measuring, like measuring the look into the DNA of the skin. I can tell if this person is accelerating the aging process or not because we're able to measure what we call the biological age. And this biological age of a person that's 36 years old can be like 54, 44, 39, can be 36 or younger, and mainly it's because of lifestyle choices.

Okay, so sun, I got it. Smoking, I got it. What does exercise do, and could it go either way?

Yeah, exercise, something like, especially for women, more and more we, we need to be careful with the amount of exercise. Some people get so crazy with the exercise and they over-exercise and create more stress to your body and even like deregulate hormones and things like that. So exercise, it's always beneficial. We need to move our body. We need to be active because— and also help our muscles to sustain our body as we are aging. And this, when we are exercising, we release a lot of like good, good things to your body that can help also on your mood, on your appearance. Sometimes I say like the skin is reflecting what you're feeling inside of yourself. And this all like if you're feeling well, if you're eating well, this will show on your skin as well. So exercise can help your skin to appear better and can help also like releasing some cytokines that can even like stimulate collagen production on the, on the skin. Excess of exercise can create too much of cortisol, increase of cortisol. Of stress level in the body. And this may be not beneficial either to your skin or to your overall health.

So good. Yeah. And I think that's such a great declaration that there's a saying, and this is very cheesy, but it's, you know, you usually older women and it's just beyond a certain mark. I don't mean old even. I really just women 40 and over, that you're choosing your face or your butt. Because if you're really going for the butt and you're trying to lose that, chances are you will begin to look a little haggard in the face.

You need to take care of both. Yeah, it can happen that, but there are also ways that you can take care of your butt and like take care of your face as well to not go to that problem.

That was just some locker room talk.

Yeah. Yeah.

Okay.

Sometimes they say, I'm a runner. I have run 2 marathons and they, I already heard like, oh, running, it's not good for your skin. And I say, it's good for my overall health. Like I'm sure it's not doing bad to my skin. Uh, so it's also, also a balance on things that you do. To look better, but more than just taking care of your appearance, like taking care of your health, I think is the most important thing that we, we need to keep in mind.

Yeah. So good. Well, I also think there is, for, for women who are here who have gone through that menopause transition, there really is a tipping point. I can remember, and many of my listeners will know, you've said this before. So I do know that I am recalling still people. But there was a time when I remember getting comments when I was on video and people would say, you don't even have any lines on your neck or anything. And I'm like, oh, you know, if you were closer, there are some, trust me. But then it was like 2 years later and it was like, boom, what happened here? You know? And it was right, you know, as menopause transition, so very likely tied to estrogen. And do you tend to see there's a dramatic— when you're looking at skin under the microscope? Do you see a drastic difference?

So what happened is like when you go over menopause, this lack of estrogen— estrogen also induces collagen production on the skin. So when you start losing this hormone, your skin starts like decreasing the amount of collagen that's being produced. And when you lose collagen, you lose the firmness of the skin, and the skin starts to become more sagging, and the fine lines and even wrinkles tend to appear more. And it's very dramatic because there is really a loss of collagen production. That's why, like everyone mentions, that they feel and they see that. So what, what one person can do is like try either to use topical creams that can help to boost that collagen production again, or also hormone replacement because you're really passing through a phase that with this dysregulation of hormones, there is a decline, especially on this collagen production and also on the hydration of the skin. And we can see like clearly in the microscope when I work with the skins from 30 years old up to 80 years old and we process them in the lab, we do several different tests. In the lab and you see the skin becoming thinner after like 50, 60 years old, it's very dramatically the amount of loss of collagen and the weakness that starts to appear on the upper layer of the skin. And this allows the water of the skin to get out. So you lose hydration, the skin starts to become dehydrated. So there is really like an impact of the menopause on changes on the skin.

Lovely. It's a, it's a two-for-one and then some, for sure.

Yeah.

What, what can women do naturally to improve collagen production?

So there are like, of course, eating a healthy diet, making sure you're having good intakes, amount of protein on your diet. And they're also like topical specifically. Sometimes people ask me like, oh, if I drink collagen, will this improve the collagen on my skin? So when you're drinking collagen, we just need to understand that the collagen that enters your stomach is not going directly to your skin and building up more collagen there. It's actually being degraded and being absorbed by your whole body and being used. It can help a little bit on the skin, but it's being used on your whole body. So, uh, heavy doing together, like having together a topical application with product that can increase the collagen, the natural collagen production of your cells. And this was what some of our research can help to counteract the fact that you're losing the collagen to try to boost that cells since they don't have the estrogen to kind of like boost them to continue producing that collagen.

That is so good. Okay, and I want to come back to this because I— you discovered that there are certain products, as you were discovering, you know, and deciding we're going to take our research and we're going to actually create a product, which I love. I remember being a master's student and, you know, having a major professor who so understood I just did not want to create a thesis that set on a shelf. I wanted something that was of utility. So she let me do a different kind of product, and that kind of project was like, okay, I'm sending this out to industry people who can use it and better. And I love that you've done that as well. But on the flip side, you discovered certain products on the market target women who are vulnerable because of noticing this skin change, that they actually accelerate aging. The very ones we're putting on to help. And every woman listening wants to know if she has something on her bathroom counter that is accelerating aging. Can you help?

Yeah. I mean, this was in the very beginning of the company and we were like reproducing the skins in the lab with different ages and we start like testing the products out there. And I remember like so clearly because I was even the one doing the experiments and we got like a very expensive number one set in sales in the US, a product that I always dreamed, almost $400 product. And I was like, oh my God, I've never seen a product that on my hands. I was dying to try on my face. But no, let's do the experiments first. And what we do is really like treat the skin in the lab and, and look how the skin will behave after being treated by that product. And we look if inflammation is increasing, if it's improving the skin barrier, if there is more collagen being produced. And this first test on this first product, when I was looking to the skin in the— under the microscope, and when I was checking the data, I I said to Carolina, that's my co-founder, I said, Carolina, I think I messed up something in the lab because the skin looks worse than it was before. So let me go back. Let me restart this experiment. And I went back and the result was the same. And we tested over and over and we started like looking to different products out there. Some were like more gentle, was not doing anything to your skin, was not being— deaccelerating aging, but was not causing any harm, which was at that time even good, but others were really irritating the skin. And this was a little bit shocking for us and was when we realized, okay, the products are not targeting what's causing aging. We have an opportunity here. But basically it's very hard, like, to someone to know, right? The market has so many products. How do I know if one, it's good or not? I would say like to look to the ingredients list. There are definitely products that contains parabens, sulfates, fragrance, mineral oils. They do tend to cause more inflammation to the skin. So there are some websites that they rate the products in terms of the safety of the products like SkinSafe. Leaf is one platform that does that. So kind of trying to look that way because it's very hard when you get on a shelf and have so many products to really to decide to yourself. I started Tessa, we test so many products here and I was like, no, no, no, no, until like, okay, we need to develop something, find something. And since 2020, I only use our products.

Oh my gosh. That's, yeah, that's a little nerve-wracking, especially if you're, you're investing Because you're— we are— we all do it. We associate the price of it with the value of it. Yeah. And assume that we must pay more for something that's really going to work. Oh yeah.

Not always is the case. Definitely. Yeah.

Yeah. So, so good to know. Okay, so the skin aging science behind One Skin, your product, results in things you're claiming to improve the skin skin barrier, the evenness, which is something most women deal with at some point in their lives, elasticity— that's a definite— reducing wrinkles, and ultimately the skin's biological age. So what has been the biggest shock? Like, skin is actually this chronological age, and yet biological age is this. What's been the biggest gap that you've seen ever?

Yeah, I mean, there are like usually most of the people have like depending on their age, there are some gaps sometimes like a skin that from a chronological age that's 50 can be like 75 years old biologically. But there are also good skins out there that sometimes a 45-year skin is like 20 years old biologically. Speaking. But basically what's happening to all of us that make also changes on this biological age is because when we are aging, we start to accumulate dysfunctional cells, cells that are damaged, that usually we call, scientifically speaking, senescent cells. But you can also hear about them as zombie cells. So when we are aging, we accumulate some damage. Our body, like our skin, usually like clean up very well the damage and everything like this. The cells still produce fibroblasts, collagen. The skin barrier is still strong. But with aging and depending also on lifestyles, you start accumulating some of these zombie cells that are cells that should be removed, but they are not. So when they stick around, they start secreting bad factors that contaminate and accelerate the aging of the skin.. And what we saw in our research was that product out there was not targeting this specific cell type. And then we start screening for peptides, new molecules that could reduce the accumulation of those zombie cells. And that's how we identified this new peptide that we call OS-1 peptide. That's a small molecule that's able to reduce the accumulation of this kind of garbage that's accumulating on the skin while we are aging. And by doing that, it can also like make the healthy skin to be in a better environment and allow them to produce more collagen. And this more collagen production also allows for a better skin barrier. And the skin barrier is so important because our skin skin does not only represent the way we look, but is an important organ that's protecting our internal body. So it's really a barrier that protects us against like several different stressors. So if your skin barrier starts to become weakened, it's weakening with aging, you are losing water, you are losing temperature, you are deregulating your system, you're being more susceptible to inflammation. So this molecule was allowing a stronger skin barrier. And we saw this like consistently in the lab on our like skin models that we have in the lab. And later on, when we did clinical studies in humans with our final product, we were able to see, measure using instruments that the skin after the use of the product is getting like stronger, this stronger skin barrier, and it's being more firm and more elastic. Wow. How amazing. Just to complement, because I'm forgetting. And then when we measure the biological age of the skin, at least in the lab, we are able to see that we can decelerate this. We can reduce the biological age of the skin. So the skin after days of treatment in the lab becomes younger. So what, what this product is doing is making your skin behave as younger while you are aging. So it's really protecting and protecting your body and protecting your skin with the skin barrier to be healthier and even at the end be a better looking skin.

Amazing. How was it that you actually— I mean, did you set out to find this? Did you stumble across it?

How did you— Yeah, we set out to found it. Like, when we realized the products were not doing that, we had a collaborator, a professor that has a library of peptides. And we said, we want to screen these molecules to see specifically if they reduce the accumulation of aged cells in the— on the skin. So, from these 200 peptides that we looked to all of them, we got to 4 molecules that was performing okay, was not like outstanding. So from these 4, we created a whole new library. So these are new peptides. And we created, we generated 800 new molecules. And we went back to the lab and we screened all these 800 molecules. And then we found, we identified, we select the top one that was the OS-1 peptide that we were able to see consistently that was decreasing up to 50% the accumulation of the damaged cells on the skin. And the end result was that was making the skin also to produce more collagen, more hyaluronic acid, more elastin, and the skin barrier was becoming stronger.

And how long has the product been out? What kind of results have you been seeing?

So that, just to have an idea that this is not an overnight thing, we started the company in 2016, only research at that time. We were like PhD scientists in the lab full time, and we were, we were like that for almost 5 years. So it took us 4 to 5 years to, to build the platform that understands skin aging, to look to the products that are out there in the market, to start screening to this new molecule, validating the molecule. And then in 2021, we launched our first product, a face moisturizer, in February 2021 in the market, direct-to-consumer. So, it's been into the market for almost 3 years.

So, that is such a— that is such a shift. I mean, really moving from academics, you know, into running what is kind of a disruptive startup, like something brand new. Nobody's heard of this, which I would imagine, like most things, skeptics, ridicule. I mean, have you had to overcome some of those obstacles?

Oh yeah, definitely. Especially because, I mean, we, we, the founding team, we come from Brazil. We did our PhDs in universities that are the best ones in Brazil, but they're not known here in the US. They are not Harvard or Stanford or Berkeley, but they have the same quality. So in the beginning, even we always worked on coworking spaces that has several different like startups, biotech startups. And you kind of feel like they are like, oh, what these girls are doing? Like, it's kind of hard in the beginning. But anytime that someone could doubt about our potential, we were working hard in the lab. And then we were like publishing our results in scientific journal. And this was like showing like, uh, how real consistent and how rigorous our science, uh, team was. And later on, we even start adding other scientists from these big institutes, uh, here from the US to our team. And it has been an incre— uh, incredible journey. Uh, the beginning was kind of like going from academia and starting the company was very still similar because we were doing only research. But then when we decided to become a brand and it's a whole new company growing around us and being like incredible to even to learn more about the branding operation, manufacture, like a lot of different things that before I never thought about it.

So I'm a little curious and this is kind of a sidetrack, but of the skincare industry, I mean, here you are, 4 women, which I really love. Love, love. I wish you were older, but I can't wish that on anybody. But because it will be so interesting to watch you and your skin age. Yeah. You know, along with the products. And, and here's the truth, your motivation will increase.

It is increasing because, I mean, I, I'm only going to one direction and I want to in 10 years from now look even better than like I look now. And although I'm still young, 36, I always had a little bit of a problem. My skin is very sensitive. Was always like, was very hard to find products that work on my skin, was always red, itching. And I mean, I see the benefits. Like I started the first version of the product that was really like a very basic Formula was done in 20— end of 2019. Since then, I switched for only using products that we, we produce. And I see that— I feel that today I look better than like 5 years ago. And I hope to keep seeing this progress with time. And I think it's even encouraging, like, to continue doing better, you know, but always in mind that more than appearance, it's like thinking about the healthy state of your skin, like keeping that strong skin barrier. This is our number one motivation.

Yeah.

Yeah. Because really, if you want to look younger, like Botox will do faster than our product. So it's kind of like this is for the long run of understanding the function of your skin and how can naturally appear better, and younger. And it's been fascinating over these 3 years to see our customers now using the product. And the majority— and we sell our products to people as young as 25 up to 80 years old, but the majority is still between 45 and 60. So our consumers a little bit older than what I am. And seeing every time, and especially in the beginning, every review that comes back, review from the product that comes back saying how this product had helped them improve their skin quality, improve like even the crepiness of their body skin. This motivated us so much to continue doing our research. And I simply— it's a part of the, of the journey that I also loved a lot. That's this interaction with our customers and learning the benefits. That they are having and the experience that they are having. That's even different from the one that I have because I'm a little bit younger.

Yeah. Well, and I so love that you're dealing with the crepey skin. I mean, honestly, that is the number one complaint from our community members. We did— gosh, with the pandemic, time is such a thing right now, but probably back in 2017 and '18, I did a series of Flipping 50 TV seasons. We did 3. There's 39 episodes, 13 each. But the very— I want to say it's, uh, it was episode 18, so it was in our first batch. Um, and right away we got the question, but it kept coming up. I was like, no, we're going to target ones about muscle and, and bone and brain health. And the neck kinks women get and all of those. And then this question about skin kept coming up over and over and I'm like, I have to answer this. And so, you know, I had to weigh in and then recruit a friend of mine to talk about skin, you know, from a plastic surgeon, you know, holistic skin doc side of things. It is crepey skin. It is whether or not you've lost weight. It's whether or not you're at your ideal body weight. I have it, you know, it's showing up. And, you know, I think it is one of those things that you don't feel that you should have that. You feel good, you're, you're fairly fit, you're energetic, and yet, huh, look at that. So it It's definitely an issue.

Yeah, absolutely. And especially because we are kind of like our mindset, we always, always take care of our face skin, but we never— we are not used to take care of our body skin. And because like the face, the skin in our face starts showing the signs of aging earlier, like even when you turn from 20 to 30, 30 to 40, you start seeing that changes. But the crepiness on the skin start to, to show up more later in our lives. So we have not like the use of like treating the body, this giving the care to the skin in our body as we do to our face. And then eventually when start to have the crepiness, then we realize, oh my God, I don't like this. So one very interesting thing, because the crepiness is also associated with the lack of collagen being produced on the skin, on the body. So we have formulated a body lotion that also contains our peptide, and we have been seeing like an improvement on crepiness skin. Like a lot of people like saying, oh, I couldn't use shorts anymore and now I feel comfortable, or like short sleeves, blouses with short sleeves. And it's very interesting to see that we can still treat crepey skin and improve. And it's very important sometimes. Yeah, the skin is also, you said, is very well associated with the muscles and the fat that you have like under the skin. So in cases of a lot of weight loss, a topical product can improve a little bit the appearance, but you still have the skin will not get completely rejuvenated by using a topical product. If you have like loss of weight and structural fat or muscles under the skin, but definitely you can improve a lot the appearance of the skin by using some topical products that increase the collagen on, on your body skin.

So beautifully said. All right, listeners, I know you probably got a few questions that I did not ask. However, we are gonna link you up, and then we're gonna put a link to the OneSkin product at Flipping50.com/oneskin. But for now, if you want to come over and review any of the show notes and some of the background of Alessandra's science and her her credentials, which are very, very justified. You can find show notes at flipping50.com/solution-for-creepy-skin. And what are you waiting for? Let's start flipping 50 today.