BIO from the BAYOU: Build Your Biotech Network with Key Opinion Leaders and Investors

10 Jun 2026 · 28 min

0:00

In this BIO from the Bayou podcast episode, host Dr. Elaine Hamm interviews Dr. Rafael Rosengarten, founder and CEO of Genialis, a precision oncology company that leverages AI foundation models to accelerate drug development. The conversation traces Rosengarten’s personal journey from a 2011 post‑doc in Houston to founding Genialis, highlighting early collaborations with Slovenian data‑science researchers and the inspiration to build a cancer‑biology foundation model before the term existed. They discuss the technical challenge of high‑dimensional, low‑sample‑size (HDLSS) data in biomedicine and Genialis’s modular “Lego‑brick” approach that assembles small, interpretable ML models to create robust predictors from limited clinical trial data, especially using RNA‑seq as a rich yet practical assay. The dialogue shifts to the broader evolution of AI in healthcare over the past decade, noting the rise of big data, generative chemistry, and the post‑ChatGPT hype that pushed AI into mainstream biotech. Rosengarten emphasizes responsible AI adoption, the need for human‑in‑the‑loop guardrails, and the work of the Alliance for AI in Healthcare to address bias, data gaps, and regulatory education. They also reflect on societal concerns: energy consumption of AI, the impact on education, cognition, creativity, and the importance of soft skills. The episode concludes with announcements of upcoming industry events (ASCO, BIO), partnerships with Connect, Tulane, Cadenza, and a festive Fat Tuesday reception, underscoring the community aspect of biotech innovation.

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