In this MIT Technology Review Narrated episode, editor Matt Honan introduces a story by Antonio Regalado about recent claims from pharmaceutical giants Eli Lilly and Novo Nordisk that their GLP‑1 weight‑loss drugs—tirzepatide (Mounjaro/Zepbound) and semaglutide (Ozempic/Wegovy)—slow biological aging. The companies presented data from clinical trials using molecular aging clocks, including proteomic clocks (protein‑level based) and epigenetic clocks (DNA‑methylation based). Across large cohorts (Novo’s 10,052 participants, half on drug, half on placebo) and smaller Lilly studies, participants on GLP‑1s showed reductions in estimated biological age of roughly 2–3 years overall, with some organ‑specific clocks indicating up to a 4‑year slowdown. Experts such as Steve Horvath, Vadim Gladyshev, and Alejandro Aguayo‑Orozco discussed the geroprotective implications, noting both enthusiasm and caution. The episode also covered broader health benefits of GLP‑1s (improved kidney function, lower blood pressure, reduced mortality) and side‑effects like muscle loss. Industry impact is highlighted, with GLP‑1s generating over $36 billion in 2025 revenue. Future directions include a $38 million ARPA‑H study in Texas to test semaglutide’s anti‑aging effects in healthy older adults and to shape regulatory pathways for longevity therapeutics. The narrative balances promising early data with the need for further validation.
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Antonio Regalado writes, weight loss drugs show signs of slowing biological aging, say drugmakers. Popular weight loss drugs may do more than help people shed pounds. They may also melt away the years. Drug giants Eli Lilly and Novo Nordisk say patients taking their drugs age less quickly According to readouts from molecular aging clocks. Such clocks assess a person's biological age by looking at changes to DNA that accumulate with time, or in newer versions, by tracking levels of key proteins. Both companies found that overweight or diabetic patients taking the drugs, called GLP-1s, had reduced biological age compared to those taking a placebo, although the difference varied widely depending on which type of clock was used and what organ was tested. Overall, the difference was around 2 to 3 years, according to Nikolai Rhode, a global project leader at Novo, who says the company has been seeing improved biological age in our patients across trials and across different tissues. The findings add to wide speculation among scientists that GLP-1 drugs, as they are known, are acting on basic causes of aging and might be a true longevity treatment. 2 years is a pretty strong effect in my book, says Steve Horvath, a professor at the University of California, Los Angeles, who's credited with inventing aging clocks. Horvath says the emerging data could provide evidence that these GLP-1 drugs are actually what is known as geroprotectors— medications that slow or possibly even reverse biologic aging. The companies shared their findings over the weekend during Aging Research and Drug Discovery, a conference devoted to seeking scientific remedies for old age. While that quest has not yet produced any clear-cut success, some scientists now think Novo's drug semaglutide, sold under the names Ozempic and Wegovy, is coming close. In an unhealthy population, I do think it's an anti-aging drug. says Vadim Gladyshev, a Harvard biologist who assisted Novo with its molecular measurements. But in a healthy population, no one knows. The drugs cause weight loss by stimulating a receptor, GLP-1, that tells your brain you're not hungry. Yet real-world studies have shown much wider benefit. The drugs improve kidney function, reduce blood pressure, and even sharply cut the overall chance of death. If the question is, can semaglutide reach several diseases relevant to healthspan and aging, we know we can say the answer is yes, said Alejandro Aguayo-Orozco, a senior scientific director at Novo, the Danish drug giant, during the meeting. The next question to answer, he said, is whether such effects are accompanied by changes to molecular measures of biological aging. When you intervene with semaglutide, does it actually move the clocks in any direction? And the answer is yes. The company found that over time, the drugs cause a wide slowdown in aging clocks, as much as 4 years in the case of a clock that looks at heart proteins. I think it's pretty clear that the organ age is shifting, said Aguayo-Orozco. The studies are also a huge boost for the science of aging clocks. Although these measures reflect a person's age, it's been uncertain they are useful as true biomarkers. Now, clockmakers have evidence that their readouts show a drop in age when people take drugs with broad, well-demonstrated benefits. The clock people have been pushing for a decade to get this kind of study done, says Yuki Ji, a biologist who previously worked in the field and now runs a startup, Reflector Bio. It's huge for them. As part of its study, Novo took blood draws from 10,052 people, Half on the drug and half on a placebo. Their blood, collected at the start of the study as well as months later, was then measured with proteomic clocks, which use levels of key proteins to predict a person's age and risk of dying. Scientists at Eli Lilly performed similar research on their GLP-1 drug tirzepatide, using so-called epigenetic clocks that assess age by counting accumulated changes to DNA. Lilly's study was smaller, but also found that for the most part, molecular time moved more slowly for people on the drug. All the clocks are telling a consistent story that we're seeing a reduction in age, Kevin Duffin, vice president for aging research at Lilly, said during the conference. It's not like we're going to reverse age by 30 years or something, but it's a significant reduction. The molecules have become the best-selling drugs in the world, with Lilly's tirzepatide sold as Mounjaro for diabetes, and Zepbound for obesity topping the list with more than $36 billion in revenue to the company in 2025. Novo's semaglutide, also sold under more than one name, was a close second. Alex Zavarankov, the founder of Insilico Medicine and the organiser of the Boston meeting, says that extending lives by even one year across the world's population would be equal to tens of millions of lifetimes. Last month, Zavarankov showed that one of his company's drugs for a lung disease also reversed the signals from aging clocks. That drug is experimental, but Zavarankov has sought to promote the idea that humanity is entering a new era of longevity medicines. He also disclosed during the event that he has been microdosing the available weight loss drugs, even though he is not overweight. I am on tezepatide, and I am an equal opportunity injector of semaglutide as well, Zavarankov said. It was part of an effort to directly raise the question of whether the first mass-market anti-aging remedy is already here. Do you think a reasonable person should start taking semaglutide? He asked Aguayo Orozco, the Novo scientist, in front of a crowded audience. I'm not a physician. I cannot answer that question. replied. Several people cautioned that GLP-1 drugs do have side effects, including muscle loss. That is one reason they might not help most people, says Horvath, who says he isn't ready to take the drugs himself, although he's thought about it. Clearly, the drugs have many benefits in obese people, but I did not yet see sufficient evidence that they will benefit skinny people, he said. I guess we will have to wait. Answers could start to emerge in a year or two. In January 2026, a US agency, ARPA-H, put $38 million toward a study in Texas that will attempt to determine whether semaglutide has anti-aging effects in healthy people over 60. That research will look at changes in cognition, mobility, and acuity of the senses. That project also seeks to help define a regulatory pathway for anti-aging drugs and to build a new therapeutic industry around longevity. You are listening to MIT Technology Review, where Antonio Regalado writes, Weight loss drugs show signs of slowing biological aging, say drugmakers. This article was published on 6 October 2026 and was read by Jane Wing. Fennoa.
