293: Josh Wolfe On Investing In Frontier Technology

16 Jul 2023 · 86 min
Episode

16 Jul 2023 · 86 min

0:00

Podcast episode (Pomp Podcast #293) featuring Josh Wolfe, co-founder of Lux Capital. Wolfe discusses his background (Brooklyn, Cornell, early interest in biology), the founding of Lux to focus on deep tech/physical sciences (nanotech → deep tech), and the firm’s thesis: find outcast/contrarian scientific founders working on interdisciplinary, hard-science problems. He describes diligence practices (heavy use of external sources, networks, Nobel laureates), the virtue of outsiders in science (science as conjecture, not consensus), and concerns about censorship and leadership in shaping public beliefs. Wolfe gives nuanced views on Elon Musk/Tesla — admiring vision and engineering talent but criticizing mendacity and messaging — and on Ray Dalio (respecting research, wary of cult/opacity). He surveys technology areas he’s excited about: computational biology (in silico drug discovery, delivery vectors like virus/non-viral), searching for human genetic outliers (Variant), brain–computer interfaces/gesture control (Ctrl Labs), capture–simulate feedback loops (Matterport, AI + sensors), autonomy (Zoox, Waymo), satellite robotics/servicing, and near-term space economics (satellite constellations, defense). On crypto, he supports distributed ledgers’ math but is cautious on currencies; sees bitcoin as gaining intersubjective belief alongside gold as inflation/monetary hedges. Finale touches on aliens (open to microbial/extreme-life) and recommended reading (Poor Charlie’s Almanack, behavioral/mental models, Cialdini).

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