7 POWERFUL Ways to Reduce Histamine Inflammation Naturally

Have you ever wondered if you could lower histamine naturally? Today we're going to go over seven ways that I've used with patients over the past many decades to do exactly that. This would be sort of like one of those countdown videos. So we're going to go all the way from seven down to one. The first way would be to lower the supply side to slow the release of histamine. So if we think about histamine, it's released from inflammatory cells that are usually used by the immune system, trigger an immune response. The ones that we talk about the most are things like mast cells. And you've heard of mast cell activation syndrome, mast cell disorders, et cetera. Well, the mast cells release histamine and a bunch of other things that are generally pro inflammatory. So if we can do something to lower their activity, we can wind up with less histamine. Now in the drug world, if someone's having a real bad time, they might get steroids because that sort of stops them from releasing histamine. Go down a step to a drug like cromolyn, chromolyn sodium. And chromolyn sodium is actually a drug that is made from a plant. And the part of the drug that they use, the part of the plant that they use to make the drug, is the flavonoid part. But it is a drug. So what could you do naturally? Well, you could take natural flavonoids, often called bioflavonoids. So that's going to be our first step that we might do. So what do they do? They go and you get in your system, they go to the mast cells and they to the receptors on the outside and stop the mast cells from hyper reactively pumping out histamine and other stuff. What's the good part about flavonoids? They're very useful, they're very simple to use. They're easy on your body, very safe. What's the troubling part about bioflavonoids? They don't work like steroids where you take one dose and you can shut it off. You have to keep feeding your system with them. That's whether you use the drug kind like cromolyn or a bioflavonoid supplement or even in food, it has to keep going into your constantly. So for example, when we prescribe a drug, flavonoid, it's used usually four times a day. And people often don't like to take things four times. They forget. But that's the way it works the best certainly at least three times a day, but four or five times in really bad cases. So you have to use it persistently regardless of whether it's a drug kind, natural kind. So what would a bioflavonoid be from nature? Well, they tend to come. You can look up bioflavonoids, you get lots of info from the Internet but basically it comes from the protective part of plants, either in the fruiting bodies or other parts to it's sort of an antioxidant protection. So if you're going to take them supplement wise, you would think of things like hesperidin or quercetin or rutin or there's many, many bioflavonoids, right? Well, there are preparations that I have personally found with patients that are very allergic, atopic types of people that help the absorption of these flavonoids. And I usually have people do those if they're, you know, needing more support. So rather than taking just plain quercetin, we might use a quercetin chalcone, C H A L C O N E chalcone, which is just a way to manipulate the quercetin so it absorbs better in your gut. Or there's also a hesperidin methyl chalcone or hmc that's a really, really good one too. Both of those work really well. And then there's others that you can use. But bioflavonoids is going to be the first one on our, on our countdown here. Now the next areas are really going to focus around not the supp side but the elimination side. So the first one would be to assist elimination via a process called acetylation. And the bottom line with that is, is that this is the simplest pathway to help you get rid of histamine out of your body. And the simplest because it's got one step, but also it's an enzymatic pathway, meaning that there's cofactors, also known as coenzymes and it's a simple CO factor. So it's one thing you could increase in supp to help out. So the N acetyltransferasetylation pathway to get rid of histamine runs on vitamin B5, B5, pantothenic acid. Here's the thing, your B complex might have 10, 20, 100 milligrams of pantothenic acid in it. That's not enough to run the N acetyltransferase system. If you have allergy or histamine intolerance or something else, we generally start with a higher dose to support histamine removal and then work our way down. So what I generally do, and again you check this out with your healthcare provider. But just historically what I've done with patients all these years is somewhere between 500 and 1000mg of vitamin B5 with food three times a day and then do that for four to six weeks and then try less and see if that helps. So if it's helping at 1000mg 3 times a day, go to 1000mg 2 times a day and 1000mg 1 time a day and then you'll see if it helps along. And that's generally what we do. You do more on the front end and less as you go along the neck. Next, if you're keeping track, this would be number three would be to use a support for another pathway called DAO or diamin oxidase. So one way to do that would be to just take a DAO supplement which will help a lot in your GI tract. So there are DAO supplements that's actually supplying the enzyme. Your gut uses a lot of that. So that's fine to take. But way number four of helping out is going to be to support DAO via its cofactors. So DAO is also an enzyme, diamino, and it uses cofactors in it. It uses a number of them. The big ones that it uses are vitamin B6 and magnesium. It also uses vitamin C and copper. Now some people don't need extra copper, so you could leave that out. Or if you get it in a multi mineral at low dose, that's probably fine. But B6 and magnesium are going to be supportive no matter what. Vitamin C is going to be supportive no matter what. So we're halfway through a little bit more, then we get to the next ones. And this is supporting the complicated pathway which often is labeled by its first step, which is the histamine and methyltransferase or HNMT pathway. But that's really just the lead enzyme because it's got a number of steps. So you might say, well, why don't we just support the simpler ones like DAO and acetylation and leave the complex one alone? Well, the complex one has, it pulls a lot of the weight in the body. So it's good to support the simple ones. And I do those first usually just to kind of let off the extra histamine. But we want to support, support the HNMT pathway from the bottom up. Now why would we do that? Well, because in some People, because you got to remember at each enzymatic step, you could go really fast in one and then stop. And there's an intermediate that's made. Well, the worst intermediate for your allergy histamine symptoms is actually the first one that's made in the first step, and it's called methyl histamine. And I would tell students, methyl histamine equals evil histamine. It binds harder to your histamine receptors. So let's say I make a bunch of methyl histamine. I think I'm getting rid of the histamine, and it gets trapped. I can't get rid of it. My patient gets worse. Their histamine symptoms get worse. So what's one way around that? Let's not start at the top of this long pathway. Let's start at the bottom and support from the bottom up. Why? Because that opens the door at the end and gets that running, and then it opens the door in the middle and gets that running, and then it opens the door at the top. And so by the time I make the first step at the top, make methyl histamine, the other doors are open and it can get out. We don't want to trap any histamine metabolites. And there's others that can make you feel pretty bad, too. But methyl histamine is the worst. How do we do that in reverse order? So number five is the bottom of hnmt, and that is an aldehyde enzyme step. You actually make a histamine aldehyde at the end. Now, you may know what aldehydes are, you might not, but there's another aldehyde that you can in your body that makes you very sick also, and that's called an alcohol aldehyde. Okay, there's different forms, but alcohol aldehydes are responsible for hangovers and all sorts of unpleasant symptoms. Your body doesn't like to hold on to aldehydes. They're neurologically toxic and they make you feel horrible. So the aldehyde step at the bottom is the final way out. So let's get rid of that first. And there's two B vitamins that work there, vitamin B1, thiamine, and vitamin B3, which niacinamide, nicotinamide, etc. Now, in modern times, everybody's really hot on NAD therapy, which is active B3 therapy. That is the actual cofactor that works there. So you might say, well, all right, so what would I take to help that out? You could either just take thiamine, you know, around 2 to 300 milligrams or better. You could take active thiamine called benfetiamine, which we use in diabetes and other stuff, and that you only really need about 100 milligrams of benfotiamine, which is active thiamine. On the B3 side of things, you could take niacinamide, nicotinamide, the non flushing form of B3 niacinamide, 500 to 1,000 milligrams. Or if you're doing an NAD primer like nicotinamide riboside, you might only need 100 milligrams or 150. That helps the last step, the aldehyde step, open up. So that's number five. Number six, we're going to move up a step and that's monoamine oxidase. Now, we already said diamine oxidase is another way out, right? Monoamine oxidase is its cousin, right? And monoamine oxidase is super important to support, not just because histamine tries to get out through there, but also because other things try to get out through monoamine oxidase. Dopamine and norepinephrine go through there. Estrogen and other hormones go through there. It's a very busy enzyme step. So you imagine you have all this histamine trying to be taken out through monoaminoxidase, and then you're trying to get rid of, you know, excess dopamine, neurotransmitters, estrogen, other hormones. You're going to really bottleneck up there. So and uses lots of nutrients. It uses kind of the same ones that its cousin Dao uses. The important ones are going to be magnesium and B6, kind of the same as before. It also uses a little bit of riboflavin and then it also uses vitamin C. So pretty much, if you're going to support the nutrients on Dao, you're also going to support the MAO side as well. And you might say, well, relatively speaking, you know, what are we talking about here? If you have a good active B complex, you may get enough riboflavin in that to take care of it. Magnesium, you have to be careful with bowel tolerance and stuff. But let's say you have a absorbable form, magnesium glycinate, or one of those forms. One to 200 milligrams is usually plenty of that. Maybe a little bit more vitamin C, again, bowel tolerance, but at least thousand milligrams a day. And then the vitamin B6 depends on what's in your active B complex. If you have a P5P in your vitamin B6, which is better because it's active and you've got 30 to 50 milligrams, that's a good start. 100 milligrams for bad allergies. Allergies probably a little bit better. Now we can open up the methylation step and it won't get trapped at evil histamine, also known as methyl histamine. So that one is supported by vitamin B12 and active folate. That could be a number of different ways to take that methyl B12, the active form of B12 is a good one. The other forms preactive forms of B12 or collaterally active forms of B12. Sometimes you'll see a B12 that has, you know, a few different forms in it. It's got a methyl form and others that's fine too. And then on the folate side you want the active or preactive forms. So that is either folinic acid and or methylfolate. Folinic acid is right before the methylation step. It's less excitatory to people because it's not. It's pre methylated, but your body methylates it usually fairly easily. Especially if you have enough B12. You don't want folic acid. So folic acid way up here, down here, folinic acid and methylfolate very close together. In humans, the enzymes to make folic acid into the active forms are very weak. So either folinic acid or methylfolate. And again, you don't need super big amounts of this, right? Some people get really, you know, get really kind of super excitatory with folic acid that's active. So we usually start with somewhere in the B12 and folate numbers start lower, you know, 500 micrograms to a thousand micrograms. And then work your way up if you need it, but start low and work your our way up. But again we're working our way from the bottom. Acetylation, mon, aminoxidase, then the histamine methyltransferase step. And that way we've already opened the two collateral pathways, dao and nat, and we've opened the bottom and the middle of the long pathway. And now methylation is the last thing that we do. And what this basically does is it helps us in the removal of histamine on all of the natural ways our body has built into it to get rid of histamine. And it does least traumatic way. Again, first thing was what stabilizing with flavonoids. Next thing was elimination through B5 and acetylation. Next thing was two ways of DAO support and then finally we support the long pathway from the bottom up and this allows removal of histamine with less trauma, less aggravation of histamine intolerance, symptoms and signs. All right, I'm Dr. A. Please continue to like, share, subscribe, let your friends know about the channel. We do a lot public education, medical education for the public here and we really appreciate all of the support. We're going to put up some other videos. Also check out the playlist. We got a ton of histamine allergy and other type of content on the YouTube channel. I will see you all in the next video.