Your microbiome produces butyrate, a chemical that tells your immune system to repair tissue damage instead of attacking it. Without that signal, your body can start attacking itself. Long-haul COVID may work this way.
Innate immune system responds to the presence of a pathogen. I remember I gave you the analogy that it's like a blowtorch response to dealing with mosquitoes, right? You're going to kill the mosquitoes, but you're also burning and damaging the wall behind it. So when the innate system responds, it's non specific, meaning it's not responding to.
Just one particular virus or one particular bacteria.
It's responding to a region where there's a problem.
And so it just comes in carpet bombs that region, which means that your.
Own cells are also going to get damaged in the process.
Right now one of the really important aspects of immune clearing is that your own cells have to be repaired and all of your own cellular debris have to be cleaned up. And there are cells that do that, There are cells that clean up all.
Of that damage, but they have to.
Be activated by activating G protein coupled.
Receptors, by stimulating Interleukin 22.
And all of those signals come from your microbiome. Now what happens if you don't fix the damage?
Well, if you don't fix the damage.
Then all of your own cellular debris can get caught up and accidentally presented to the adaptive immune system as part of the problem. Your macrophage or your dendritic cell may accidentally grab your own tissue proteins or.
Your own tissue structures and present it.
To your T cells and B cells as the problematic or invading species. And then now you start developing autoimmune conditions.
That's how an infection can lead to autoimmunity. That's what we're seeing in this pandemic virus as well. People with long haul syndrome are seeing an autoimmune induction of their neurological system, their muscular system and so on because there was so much inflammatory damage and.
Those individuals did not have a good, effective, clear repair and anti inflammatory mechanism. And so their macrophage and dendritic cells accidentally presented their own neurological tissue samp to the B cells and T cells and then they started developing antibodies and.
Memory T cells against their own tissue.
Right? That's called a bystander effect, where your own tissue becomes an accidental bystander in the war, in the damage, and then.
Accidentally becomes a target.
So in order for that to not occur, you need a healthy microbiome producing.
The anti inflammatory signaling, producing the butyrate.
To activate the G protein, couple receptors.
On cel and stimulating interleukin 22 to repair the damage that's going on.
That has to be happening as the.
Infection is coming under control and as the immune system is progressing along towards the adaptive right.
So we cannot overstate the importance of a healthy microbiome in that whole kinetic.
Aspect of how the immune system functions.
If you don't have a healthy microbiome.
You have a huge risk of going down the road of a cytokine storm and going down the road of auto.
Activation deprivation and then ending up with.
An autoimmune type of condition as a result of that infection.
