Vitamin C and glutathione protect water-soluble parts of your cells, while vitamin E protects fat-soluble parts like membranes. When these three molecules drop, your body can't restore its oxidation-reduction balance, impairing how it regulates itself.
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But our body runs on a very simple water to fat soluble triplet, which has vitamin C and glutathione in the water soluble areas, and then vitamin E family, which are the tocopherols and tocotrienols, and they take care of your fat soluble places like your cell membranes. If these are working, then when we need to oxidize, we can, and then we go back down and we reduce, and we— it's always a cycle. If these run low, which often happens, we have a hard time modulating, getting back to that balance that we really would like to live in.