Matt Kelly explains the four histamine receptor types and where they actually work. H1 isn't just allergies, H2 isn't just your stomach, and H3 and H4 show up in your brain and joint linings. One chemical, four different receptors, wildly different effects.
You know, there's four main histamine receptors that we know about, and there's probably others. If you imagine that you get one trigger going out called histamine, then it can go to four different types of receptors that do all these different things, and you find out histamine type 1 is not just about my stuffy nose or my anaphylactic reaction. Histamine type 2 is not just about my GI tract. Histamine 3 and 4 aren't just about my brain. That adds to the thickness of the soup, as it were. When it comes to histamine reactions in your body, we now know that we've got histamine type 3 receptors and possibilities. Believe in 4 in our joint linings, synovial membranes, got histamine 1 and 2 in the brain, as well as 3, 4.
