Matt Kelly explains how infants build their microbiome from birth onward. Maternal gut bacteria reach the fetus in utero, vaginal bacteria shift during pregnancy to include more Lactobacillus johnsi, and breast milk delivers 400 to 600 bacterial species plus prebiotics. The gut reaches an adult-like state around three years old.
100 trillion organisms.
10 trillion cells.
Lactobacillus johnsi.
400 to 600 different species of bacteria.
Oligosaccharides.
We've got 100 trillion organisms that live in and on us. We've got 10 trillion cells that make up the entire human body. So from a cellular standpoint, we are 10 times more bacteria than we're human, actually. And so then the question is, well, where do they come from? And if we each have a unique microbiome, then how is it that we've developed this unique microbiome? So what they found is that, number one, it used to be the idea used to be that in utero everything was sterile. The baby was sterile in utero, there was no bacteria in there. It's a very serene and pristine environment. But what they're starting to find now is there's actually inoculation of the baby's gut and the body and the internal systems by mother's gut bacteria. So there's actually immune cells that will go to the mom's gut, grab good bacteria from her gut, transport them through the umbilical cord into the fetus. And that's such a specific system in place just to get the baby's body ready for this big inoculum that's coming. Then the big inoculum comes during childbirth itself, passing through the birth canal. Here's another interesting fact. When you look at the birth canal in an unpregnant woman, vaginal bacteria is very different than gut bacteria, of course, because you're not digesting anything down there and there's a very different environment. But at the end of the first trimester of pregnancy, there's a huge shift in the vaginal bacteria population. And in fact, the vaginal bacteria population starts to mimic the gut bacteria population. One very interesting bacteria that tends to grow in much higher numbers now in the vaginal bacteria is a species called Lactobacillus johnsi. And the primary role of Lactobacillus johnsi is to digest milk. So you may ask yourself, what is a milk digesting bacteria doing down there? And so it's really there just to prepare the fetus for life in world. Because what's the first thing a baby drinks is milk from mom. The pregnant woman's birth canal is shifted to reflect more her digestive bacteria. And then as the baby passes through the birth canal, it gets a huge inoculum of that bacteria. It swallows it, it's all over its skin and body. And that's the initial huge inoculum that you get from mom. So most of the bacteria you get, you get from your mom. Now the second part of it is a close interaction with mom. I think a lot of people have heard the whole importance of skin to skin contact, that skin to skin contact is actually important for inoculating the baby's skin with friendly skin based bacteria from mom. The second part is the breastfeeding itself. Breast milk contains 400 to 600 different species of bacteria. And what's fascinating is the biggest nutrient within breast milk are oligosaccharides. These are basically non digestible sugars that the baby can't digest, so the baby can't use these for energy. It's purely there as a prebiotic to seed the bacteria that you got from your mom. One of the biggest nutritional components of breast milk is a prebiotic for the gut bacteria that the baby just got from mom. That's fascinating. What they've shown is about 868 days after birth and breastfeeding and all that you end up with about your adult microbiota, close to three, three years is what it takes for you to end up with your adult functioning microbiota. Then what's interesting now, the way we develop the uniqueness from each individual because let's say you take a set of twins, they both got the same microbes from mom, yet they end up with different species diversity. There is some sort of co selection process that's going on when your body is introduced to all this bacteria. Your body's immune system has a co selection process where it chooses the kind of bacteria that it wants to allow to take seed and live within your gut. The ones that it doesn't choose, it rejects. So this co selection process is kind of a tissue compatibility type of thing which is not really well understood yet, but that's really where the diversity comes in. So you give person A and person B the same inoculum, 800 days later they have different species of bacteria because their body selected for different ones.
