Mast cell disorders are hard to diagnose because there's no definitive biomarker and doctors disagree on whether neurological and mental symptoms count. Most diagnoses rely on whether patients improve after taking histamine blockers or other mast cell-calming drugs.
So the big frustration there with the medical system, there's sort of 2 groups of science publications now about diagnosis. And some of the scientific publications have minimized the symptomatic changes that can help you with diagnosis, especially the neurological and mental-emotional changes. They've been minimized in some of the publications. So again, you have clinicians looking at this and saying, I can't diagnose you. We don't have a hard marker. So that makes it difficult too. So then you have to look at, do you have the symptoms? Do they respond to mast cell calming therapies? So that could be histamine blockade, that could be mast cell receptor blockers, could be steroids, could be all sorts of stuff. They do, you have some level of mast cell triggering issues.
