Methylene blue dosing varies widely between people because of differences in digestion and how well products are absorbed. Start low, around 5-10 mg, and gradually increase. Some people need 50 mg or more, so pay attention to the milligram content on your bottle.
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Doses are really broad because of individualized digestion and absorption and the product that you're using. There are some products that are extremely concentrated and they'll deliver way more milliliter than another product will. So you do have to watch out for that. Even if it's gone through good quality control, not each strength is going to be the same. But I have seen people have good responses to 5 to 10 milligrams. I've seen other people where it took 50 milligrams and other people where it took higher. But generally speaking, because of this mitochondrial effect, we tend to start low and then work up as we need it.