In this brief instructional monologue, the speaker outlines a cautious titration protocol for low‑dose naltrexone (LDN) in highly sensitive individuals. The approach recommends starting at very low doses and increasing in half‑milligram increments (0.5 mg, 1 mg, 1.5 mg, etc.), closely monitoring for agitation or other side effects. If side effects emerge at a given level (e.g., 2 mg), the clinician should back‑track to the highest previously tolerated dose (e.g., 1.5 mg or 1 mg) and maintain that plateau while addressing other health issues. After a period of stability—typically one to two months—the patient can be re‑challenged with a modest additional increase (another 0.5 mg) to see if tolerance has improved. The overarching principle is that achieving a dose that the patient tolerates is more valuable than forcing a higher dose that provokes adverse reactions, emphasizing flexibility and patient‑centered dosing.
