In this YouTube presentation Dr. A introduces a newly published open‑access review that synthesizes 139 peer‑reviewed studies on long COVID and related "spikeopathies." The review is organized into three sections: background science, clinical assessment, and treatment algorithms. Dr. A explains that spike protein can originate from SARS‑CoV‑2 infection, vaccination, or a combination, and that its presence can cause primary organ damage, secondary cytokine cascades, and aggravate pre‑existing conditions. The review details how immunologic testing (spike vs nucleocapsid antibodies) can help distinguish infection‑derived from vaccine‑derived spike exposure. A central clinical tool is the Kloc et al. 0‑4 graded dysfunction scale, which guides the depth of laboratory work‑up and therapeutic intensity. The treatment algorithm addresses (1) comorbid condition management, (2) coagulation and clotting risk mitigation, (3) pharmacologic blocking and degradation of residual spike protein, (4) immune rebalancing, (5) antioxidant nutrient repletion, and (6) mitochondrial support. Finally, the review provides expected timelines for recovery, noting that lower‑grade dysfunction tends to resolve faster than higher‑grade cases. Dr. A emphasizes that the full paper is freely accessible, encourages clinicians and patients to read it, and ends with a call to subscribe and share.
Chapters
I wanted to take a couple of minutes and go over a new publication that reviews 139 peer-reviewed scientific references and goes through both the background, the assessment, and then the treatment of people with both Long COVID and psychopathies, which we'll talk about in just a moment. Hey, it's Dr. A, and probably one of the most popular topics that we talk about here on this channel, and also that I get asked about clinically, is the topic of long COVID and COVID recovery, et cetera, et cetera. So let's get into that. First off, this is a review that I published last month, so it is very recent and new. And as I said, in going through this to try and gather all of the latest science with this very emerging problem, I went through 139 peer-reviewed references from the scientific literature and merged that with my own and others' personal clinical experience and came up with a systematic discussion and treatment algorithm for long COVID and spikeopathies. So the first thing is long COVID and spike protein damage have a lot of crossover. So as we know, we can get spike and spike increases in the body from a COVID infection. We can get spike and spike increases from vax. We can get them from both together. One of the common cores is the damage that the spike protein can possibly do, and that can be primary damage such as restrictive pulmonary disease, inflammatory disease of the heart or the kidneys, et cetera, brain dysfunctions, secondary things such as cytokine reactions and all manner of other disruptions, and then also aggravation of preexisting conditions that go on. So what we look at in this review is In the first part, we go through the science and the data that talks about what do we know as far as what comes from the post-infectious era. So you had an infection with COVID now you have these signs and symptoms. What do we know about the relationship of your COVID infection to those signs and symptoms? And then also, either alone or with a COVID infection, we look at what are the psychopathies that are potentially possible based on the current research that we have available for that. Vax and vax injury potentially, and also we look at the collage effect of what if we have both things going on. So we look at all of the data behind that. That's all in the beginning in the introduction. We look at the possibilities for different types of collateral health problems that may come from one or both of those triggers for these problems, and we look at what the research says about what we know about them to date. The next thing that we look at are ways to test to see indirectly at this moment anyway what the spike protein. And we look at ways that are based on the research to say, is that load more likely from the COVID infection itself, or is that load more likely from the vax, or a little bit of both? And there are ways using immunologic tests to not only look at spike effect, but also the presence or absence of the nucleocapsid or N protein, which we can then use to decipher, is this more likely coming from the infectious trigger or a non-infectious trigger? Yeah, I think that's a great point. So all of that has gone through in the very beginning of the article, and it goes into some depth because there's been a lot of conjecture and a lot of interesting proposed ideas out there in the world. And what I was trying to do is get through the conjecture and look at the science and look at the published data and see, well, what do we really know from what's been published up to this point? And it would take us probably an hour to go through all of that. So we're going to put a link in the description below to the article. You can go through there and take a read if you want to. Now, this is on a public access web server. And so if you're not a member of the particular site, there's no charge. You just log in as a guest and it will take you right to this publication. So the next thing is, what is a rational way that I and others who work with this clinically have found to approach people regardless of where the psychopathy came from, whether from post-infectious illness or vax-induced psychopathy or a little bit of both? At the point where you're sick, it doesn't matter as much because we have to do something about that. So what does the research tell us about ways to look at and assess and then potentially treat patients? And what does my and others' experience tell us about ways to assess and potentially treat these patients? So in the paper, in the second two-thirds of the paper, again relying heavily on current research plus all of the clinical experience of myself and others, what we go through is a graded dysfunction-based assessment. And while there There are a couple of published ways to assess post-COVID illness, long COVID, whatever you'd like to call it. What I have used all through since we started getting people with post-infectious illness, et cetera, is a particular rating scale by Kloc et al., and that is listed in the paper as well. It's a very simple rating scale, but it has a 5-part rating, 0 being no real problems, 1 being mild disability, and all the way up through 4 being severe disability. And what we know in the spikeopathy, long COVID, post-COVID world is that some people are not affected. Obviously, some people are mildly affected and some people are very extremely affected, and we have everything in between. So based on the research, we have a way of assessing people, and you can actually take a look in the paper and see the level of dysfunction and disorder disease, and you can see it's pretty easy to categorize into one of those, especially 4 pathologic categories. Now, why would we do this? The reason is that, like any complex chronic illness, post-COVID issues, psychopathies, long COVID, whatever we're calling it, have a lot of potential laboratory investigations that may need to be done, examinations that may need to be done, history that needs to be taken, and even imaging and other types of studies that need to be done. And sometimes people will come to other practitioners and they will have had pieces of the workup done, but maybe not everything. They need, but to help the practitioners prioritize by using this validated scale from the medical research. If you are at a grade one, we're going to do some basic laboratory tests, etc., that are appropriate to that level of dysfunction. But they're going to be very different than the list of things we're going to consider at a grade three or a grade four, and that's because the level of dysfunction is completely different. Now everybody essentially gets the same basic testing algorithm, and then things are added on as. As there is a higher level of dysfunction. That's just the way that it works. So this helps to save from testing and things that you don't need, but also to give ideas to you and your practitioners as to what should we include if I'm still at a heavier level of illness or disability. So that's the reason for using a graded approach. So the first part of the graded approach is what's the assessment, what grade are you in as far as dysfunction, etc., and then what kind of testing and other stuff do we need to do. Then the The next part is to look at the therapeutics that are appropriate for that level of disability and disease state. So if you are in a grade 1, the level of therapeutics you need might come from a broad list that you can pick from to see what works best, but it may be less intense than somebody who's a grade 3 or 4 needs, which is usually the case. And the people who have the most intense sort of experience and progressive disability, et cetera, usually are going to wind up being at grade 3 or grade 4, they're going to have a lot more options as far as what might be needed to be tested and treated. Regardless of where you are in that spectrum of disability and disease, as far as long COVID, post-COVID psychopathy, we're going to look at what we can do in the following areas. So one is to identify and treat comorbid conditions. So this might be something you already knew about. You had a thyroid problem or hormone imbalance or blood sugar problem. Maybe you already knew you had Epstein-Barr virus or some other chronic thing. Long COVID, spikopathies, etc., can make all of that worse. So our idea is we need to treat the rest of you. The other thing is that there's a lot of research showing that you can get a person who didn't have any trouble with Epstein-Barr— I'm just picking on that as one example— and after you start treating that person, you'll find out that the spike protein, the spikopathy, wherever it came from, is reactivating those types of virus. So to be treated at the same time. Just one of many examples. The next thing, which is very critical, is to support coagulation and clotting issues that are going on. It's almost universal that people with any level of psychopathy are going to have an increased potential towards clotting. And we want to take a look at potentials for clotting and either just be doing some preventive things that are very global, or even doing some clotting assessment and maybe doing some direct treatments. And all of those things are listed in the algorithm in the publication. The next 2 areas that are critical is to potentially block the spike protein from entering cells and then degrade the spike protein that's there. One of the problems that we see now in the research, and we see it clinically, is spikopathies that tend to be from treatment as opposed to infection can continue to produce spike protein. We now know over 200 days after the treatment was given. And so we not only need to look at spike protein impact on the immune system, but we need to do treatments to both break it down and block it from entering. And again, those agents are listed in the review as well. The other thing that is universal with COVID either during the acute COVID infection or the post-COVID psychopathy period, is it causes a lot of immune deregulation, immune imbalance. And as we go along, immune imbalance has to be addressed and treated so that we have an easier time of our body getting back into a healing state. So when we address and we treat the rest of the problems going on, we need to remember that the immune system has to be addressed so it's not getting too over or understimulated. And that's something that is spoken about in the review as well. Antioxidant nutrient status— we take a big hit in the area of just our general nutrients, but also antioxidant nutrients in the body. And usually those don't go totally away, or you wouldn't be here, but they can get depleted through the process. And so we want to make that we have support for that going on. And then a universal need is the support of mitochondrial function. And this is something that certainly is a range of things. We have a ton of mitochondrial information on the YouTube site here, but we have this big range of dysfunction that can go from primary mitochondrial inherited illness to functional mitochondrial illness, to simply disease-associated mitochondrial dysfunction, meaning it's not an inherited disease or anything, but your mitochondria, which produce all the energy in your body are still not working the way that they used to. So we're going to need to, at some point, maybe from the beginning, maybe a little later as you heal up, address the level of mitochondrial function and it might need to be supported through the process. And then the last thing discussed in the paper is really timelines and expectations for timing of healing, et cetera. So when we think about this, it is somewhat, in my personal experience, analogous to the initial disability and disease assessment. Assessment that we're going to do. So you kind of have lower grade and higher grade problems. Lower grade problems usually are going to resolve more quickly. Higher grade problems are going to take a longer time to resolve. And so we give some guidelines around the amount of time that on average people are taking to not only go through the process, but to implement the healing strategies. So again, what we're going to do here in the description box below is put a link to this paper. It's a free link. If you go to the site and you're not a member, You can sign in as a guest. You don't need to be a subscriber. You can sign in as a guest and you'll get free access to the paper. And again, it's a number of pages long and it has 139 peer-reviewed references that are cited and related to what we're saying in the paper and also related to what we're saying about assessment and treatment for people in anywhere in the spectrum of post-COVID, long COVID, psychopathy, et cetera. Really glad that we were able to get this paper out. It's been able to help a lot of clinicians work their way through this very complex problem that people are having. And it is open access. I wanted to get it out and make it published that way so it was easy to get by anybody who wanted it. And it is free for access for you, your clinicians, anybody who's interested. Thank you very much. Please do subscribe, like, share, do all the things. We love that the community is growing here. Check out the link below and we'll put some other video links up here for you as well. Thank you very much.
