Matt Kelly explains why MCAS symptoms often worsen during the first 1.5 to 2 days of fasting due to increased histamine and inflammatory mediators. He recommends working with a practitioner to manage inflammation beforehand, staying hydrated, and adjusting supplements as needed. Most people see improvement by days 2 to 3 and feel reset by days 5 to 7.
You're going to get worse in 99% of cases the first 2 days. There's very good research that shows in the beginning of a fast, you're going to dump more histamine and inflammatory mediators. This is why you may not want to do this right first, the fasting part. You might want to work with your practitioner and get some of the inflammatory mediators handled somehow, and then go into the fasting. And generally, what we hear from people is between the first day and a half to the second day, which matches the science. Histamines go up, you aggravate, you feel kind of worse. You have to stay well hydrated, maybe take extra of the other stuff you take. And then along about day 2 to 3, it starts to get better and better. And by day 5 to 7, you're often reset. Now,
