What Medication Should LDN Not Be Used With?

2 Jun 2024 · 0 min

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In this brief segment, the speaker explains that low‑dose naltrexone (LDN) should not be taken together with opioid analgesic medications. Naltrexone works by blocking the opioid receptors that opioids bind to, so using both would counteract the pain‑relieving effect of opioids and place the treatments at cross purposes. Therefore, patients who require opioid pain control should avoid concurrent LDN therapy.

What medication should we not use it with? Well, the main medication you should not use low-dose naltrexone with would be opiate drugs. So opiates are a class of opioid analgesics, and naltrexone is made to block the receptors where those drugs bind. So if we have a patient who needs opiates for pain control, you don't want that patient on naltrexone. That's not— it's going to be at cross purposes.