Mast cell disorders often underlie POTS and dysautonomia. When mast cell disease improves, POTS symptoms can dramatically improve or disappear. Clinicians should test for mast cell activation syndrome when dysautonomia worsens, since it can hide behind more obvious symptoms.
Now, in the case of POTS dysautonomia, I've definitely seen people where either it completely goes away or it gets very, very, very low level when we get the mast cell disorder more under control. Now, if you think through what I just said, the common denominator in the triad is usually mast cell problems. A question that might want to cross your mind and your clinical team's mind is, If these are getting worse, we might wanna look at broader diagnostics, take a look at mast cell activation syndrome, because often it's lurking in the background and I'm so symptomatic from my dysautonomia, whether it's POTS or some other, that it sort of overshadows the mast cell part of the problem.
