This YouTube monologue by McCall McPherson addresses whether newer GLP‑1/GIP weight-loss medications (semaglutide/Ozempic/Wegovy, tirzepatide/Mounjaro) are contraindicated for people with Hashimoto’s hypothyroidism. McPherson argues they are not contraindicated and reports clinical observations that these drugs can reduce TPO and thyroglobulin antibody levels, lower systemic inflammation, and rehabilitate metabolic dysfunction (insulin resistance and impaired weight-loss ability), while warning against widespread misinformation.
Chapters
Are the new class of weight loss medications contraindicated for people with Hashimoto's? I hear this all the time. You guys tell me it all the time because you've heard it. It's not true. And in fact, I believe the exact opposite weight loss medications like Manjaro, Semaglutide, Ozempic, Wegovy, Tirzepatide, these medications can actually serve a very impressive thing for people with Hashimoto's with hypothyroidism. And the reason is because it can influence this mechanism in this condition in a few different ways. Number one, you guys, I am seeing it actually reduce antibodies for Hashimoto's at modern thyroid clinic. I am seeing people's in their TPO and thyroglobulin antibodies move closer to remission and in some cases into remission with these medications. Why? Because we know that they influence the levels of inflammation in your body which drives antibodies, autoimmune disease, all of that. So number one, in fact, they're not contraindicated. In fact, they can help reverse and reduce the severity of Hashimoto's. Number two is they help to unravel and heal the metabolic damage that happens with Hashimoto's. These weight loss medications can take the damage that's done to your thyroid, Thyroid function that creates inability to lose weight, loss of insulin resistance, poor blood sugar, metabolism, and it can rehabilitate that so that in the future you can, with appropriate effort, lose weight when you diet and exercise, lose weight when you eat well, when a lot of times people with thyroid conditions actually can't do that despite massive efforts. So let's change this dialogue around this. It is so important to, to know the facts because there is a tremendous amount of misinformation circulating about these medications.
