From PCOS & Hypothyroidism to Long COVID

1 Oct 2026 · 37 min
36:59

In this podcast episode, host McCall McPherson interviews Nicole Duran, co‑founder of PureForm health clinic and host of The Healthspan Collective. Nicole recounts her health journey that began at age 16 with a diagnosis of PCOS (now termed PMOS) and later hypothyroidism, describing the rapid weight gain, hormonal changes, severe fatigue, and brain fog she experienced. Conventional treatments such as birth control and metformin failed to improve her condition, leading her to explore functional and integrative medicine. She emphasizes the importance of long‑term doctor‑patient relationships and how her mother’s OB‑GYN helped her get a proper diagnosis. Nicole describes her shift to a whole‑foods, bio‑individuality approach after a health coach introduced her to eliminating processed foods, gluten, and dairy, and to mindfulness practices. She studied at the Institute of Integrative Nutrition, which deepened her understanding of personalized nutrition. She later incorporated modern tools like GLP‑1 agonists (tirzepatide), various peptides (thymosin α‑1, lorazotide), and micro‑dosing strategies to manage inflammation and weight. The conversation moves to her fertility journey. After being warned that PCOS could make pregnancy difficult, she optimized her body with supplements (CoQ10, fish oil), strict diet, reduced alcohol, and limited travel. Within three months she conceived, noting that while lifestyle optimization helps, fertility also involves an element of luck. Nicole then details her experience with long COVID, which began after a highly stressful period surrounding her wedding. She suffered severe fatigue, histamine spikes, and was eventually diagnosed with mast cell activation syndrome (MCAS). Treatment involved a multidisciplinary team, including RD Michelle Shapiro, and a regimen of GLP‑1 micro‑dosing, thymosin α‑1, and lorazotide to restore gut integrity and calm the immune system. A major focus is on the clinic’s proprietary therapies: Extracorporeal Blood Oxygenation and Ozonation (EBO2) and Therapeutic Plasma Exchange, both blood‑filtration methods that remove inflammatory proteins, micro‑plastics, and toxins, followed by ozone‑enriched oxygen and red‑light therapy. Nicole explains the procedure, its benefits for conditions like Hashimoto’s, Lyme disease, and PCOS, and how it has become a quarterly maintenance treatment for her. Finally, Nicole shares the growth of PureForm and its partnership with Humanaut Health, describing the range of services offered—stem‑cell therapies (including Muse cells), advanced diagnostics (VO₂ max, DEXA, carotid ultrasound, grip strength), red‑light beds, infrared saunas, cryotherapy, and concierge medicine. She highlights the mission to empower women with personalized, integrative care and directs listeners to her Instagram, website, and podcast for more resources. Overall, the episode weaves personal narrative, clinical insights, and business development to illustrate how a combination of lifestyle fundamentals, cutting‑edge regenerative therapies, and individualized treatment can transform chronic hormonal and post‑viral conditions.

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