McCall McPhersonFounder, Modern Thyroid Clinic.

GLP1s and Hashimotos 🤝🤝🤝 #hashimotos #hashimotosthyroiditis #hashimotosdisease #glps #glp1 i

28 Jun 2026 · 2 min

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In this clinical commentary, McCall McPherson of Modern Thyroid Clinic explains how GLP‑1 medications can dramatically improve outcomes for patients with Hashimoto's thyroiditis, especially those who have exhausted lifestyle interventions. He reports that GLP‑1 agents reduce systemic inflammation within about 48 hours, quickly lowering the high inflammatory burden typical of Hashimoto's. Over longer periods, patients show consistent reductions in thyroid‑specific antibodies when measured every three months, even without additional lifestyle changes. These immunologic improvements are accompanied by better blood‑sugar regulation, more effective thyroid hormone activity, and overall symptom relief. McPherson emphasizes that Modern Thyroid Clinic has amassed what he believes to be the world’s largest dataset of thyroid patients on GLP‑1 therapy, providing ongoing, real‑world evidence of these benefits.

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A GLP-1 can be life-changing for people with Hashimoto's. I especially love to see this in my thyroid patients who have literally done everything. They've exercised, they eat right, they do so much more than humans should have to do, and they can't move a needle. And then they go on a GLP and boom, their whole life changes. And that happens from so many different facets. But number one, within 48 hours inflammation reduces. And inflammation in thyroid people is huge. Hashimoto's even more. We are inflamed. And a lot of times it's not influenced enough by diet to make a difference. So this just takes the volume, turns it way down right away. It changes the way our blood sugar shifts. It actually reverses and reduces Hashimoto's antibodies. If you asked me this 5 years ago, I wouldn't have known,, but we just happen to run a massive amount of data on people at Modern Thyroid Clinic who take GLPs, who are in our weight loss program, and we analyze that data constantly. I honestly think we might have the largest data set in the world of people with thyroid conditions on GLPs, and what we found was pretty cool. We found that GLPs almost ubiquitously, meaning almost across the board, reduce antibodies. We check them every 3 months,, and we see them reduce despite no real other lifestyle changes, which also makes people feel better. It makes their hormones sometimes activate better. So it impacts all these facets in people who can't influence them with their own effort. And it's been one of the coolest, most exciting things I've been able to witness in my career.