McCall McPhersonFounder, Modern Thyroid Clinic.

Hormone Therapy: Does it REALLY Increase Breast Cancer Risk?

3 May 2025 · 1 min

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1:13

Short excerpt from a McCall McPherson YouTube video ("Hormone Therapy: Does it REALLY Increase Breast Cancer Risk?", uploaded 2025-05-03). The speaker argues that hormone replacement therapy (HRT) does not increase breast cancer risk and may improve outcomes. Cites the Women's Health Initiative estrogen-alone arm (conjugated equine estrogen) as showing a 23% reduction in breast cancer, notes an ~80% decline in HRT prescriptions since 2003 while breast cancer incidence rose, and claims HRT users have less aggressive disease and better outcomes compared with non-users.

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But when we actually look at the data, even the data out of the Women's Health Initiative, the benefit of hormones is undeniable. And in the estrogen alone group, and that wasn't even bioidentical estrogen, right? That was conjugated equine estrogen, which is horse estrogen and has 30 estrogens that are not even endogenous estrogens. These are estrogens that our body hasn't even seen. And even then there was a 23% reduction in breast cancer. 23%. Now when we look at the population of women that take hormones as compared to the population of women that don't, they both get breast cancer, right? We've seen since 2003, like an 80% drop off in hormone replacement prescriptions. And yet what happened with breast cancer incidents? It just went up, right? So that didn't change. Breast cancer incidents. So both groups get breast cancer. But when you look at the women who take hormone replacement and compare them to the women who don't, they have better outcomes, they have less aggressive disease.