Short YouTube clip by McCall McPherson (founder of Modern Thyroid Clinic) explaining low-dose naltrexone (LDN) for autoimmune thyroid disorders. McPherson defines LDN as microdosed naltrexone (example: starting 1.5 mg vs standard 50 mg), describes a proposed mechanism—brief opioid-receptor blockade that upregulates endogenous opioids—and claims broad anti-inflammatory and immunomodulatory benefits. He applies LDN clinically to Hashimoto’s and Graves (reports using it in nearly all Graves patients), cites an anecdote of a >500-point drop in TPO antibodies over three months after starting LDN, and mentions potential anti-aging and anti-cancer-supportive effects. Research links are promised but not provided in the excerpt.
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LDN or Lotus Naltrexone is honestly a pretty miraculous medication in a lot of ways. McCall McPherson here, thyroid expert and founder of Modern Thyroid Clinic. So low dose naltrexone or LDN is used often for autoimmune diseases like Hashimoto's or MS, multiple sclerosis or I use it in people with multiple autoimmune diseases. Why? Because it's freaking impact is incredible. So low dose naltrexone is a microscopic amount of a medication called naltrexone that's used as a pain medicine antagonist, as an opioid antagonist. It blocks opioids when you make it into microscopic amounts and you give it to someone. So I'm talking about starting doses of 1.5 milligrams, where normal starting doses is 50. You give it to that person and you titrate them up a couple times. What it actually does is it blocks a tiny, tiny bit of their opioid receptors and their opioids and it, it tells their body, it sends a message and says, hey, we need more opioid production. We're in a depleted state. So your body actually increases and produces extra opioids. So instead of reducing your natural levels of opioids, it puts you in a state of excess. What does that do? A heck of a lot of things. So it lowers inflammation from anything. So it doesn't matter what's driving the inflammation that's creating your autoimmune disease like Hashimoto's, it lowers the inflammat response that's driving that mechanism, whether it's food, whether it's stress, whether it's genetics, anything. So it turns down the volume of your inflammatory response. At the same time, excess opioids change your immune system in such a way to lower inflammation but not weaken your immune system, not in an immunosuppressive way and in an immunosupportive way that actually can promote the pruning of weak cancer cells to protect you from cancer. It also breaks slows the breakdown of your body due to aging over time. So it has a lot of anti aging benefits. To give you an idea, I have seen someone's TPO antibodies, their thyroid peroxidase antibodies reduce over 500 points in three months without changing anything else and adding an LDN. I also use it in almost, if not all, 100% of my graves patients. It is a very quick way to get someone's GRAVES antibodies down, which means the fluctuations in their thyroid function massively reduce. So pretty, pretty incredible. I'LL try and post some research articles about it. You guys like. Please Comment Follow Stay tuned. So many more thyroid things to come.
