McCall McPhersonFounder, Modern Thyroid Clinic.

Transform Your Health: 3 Steps to Influence mTOR

26 Mar 2025 · 1 min

Watch on YouTube

0:36

A short YouTube interview/Q&A where McCall McPherson asks an expert (Speaker B) for practical steps to influence mTOR signaling. Key guidance: improve metabolic health to enable proper mTOR on/off cycling, consider a lower-protein but protein-sufficient diet (meeting per-kg recommendations, aiming below ~10% of calories), and use fasting to improve nutrient sensitivity; a final audience question asks about links between mTOR and GLP‑1 medications.

Love for you to share three ish practical steps that people can take and implement in their lives to influence mtor.
Generally speaking, being in better health is associated with lower MTOR signaling in general, and so obesity and insulin resistance work in part by raising MTOR activity. So people who are in better metabolic health are going to have lower MTOR activity on average, or more importantly, they're gonna be able to turn MTOR on and off during the day as they're supposed to and as nutrients become more available or less available.
About a low protein diet.
Is definitely associated with lower MTOR activity and that's gonna be a diet that is probably still protein sufficient so meets those recommendations of around 0 point grams per kilogram of protein, but it's probably below 10% of daily calories. Fasting could definitely help improve sensitivity to nutrients for both MTOR signaling and other signaling pathways as well.
Thank you for that. And then I have one final question that is purely out of my own curiosity, selfishly and and there might not be any research to date about this, but I'm curious if there is or if there is research being conducted on the influence of MTOR with the utilization of GLP1 medications.