McCall McPhersonFounder, Modern Thyroid Clinic.

Unlocking the Secrets of LDN: Dosing Explained

27 Jan 2025 · 1 min

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0:48

A short YouTube monologue by McCall McPherson explaining low-dose naltrexone (LDN). The speaker defines LDN as a microscopic (compounded) dose of naltrexone, contrasts it with standard naltrexone dosing (normal dosing ~50 mg), and describes a proposed mechanism: microdosing partially blocks endogenous opioids, signaling the body to increase its own opioid production.

Chapters

Let's talk about ldn. LDN dosing. I get this question a lot. The dose of LDN or low dose naltrexone, which let's back up and say exactly what that is. It is a microscopic dose of a medication called naltrexone. Naltrexone is an opioid blocker. It is a pain medicine blocker. When it's compounded into microscopic doses, normal dosing starts at 50 milligrams. Compounded can be any dose you want it to be. It does something unique at a microdose. It blocks a small amount of our natural endogenous opioids that we produce ourselves, and that communicates to our body that we don't have enough opioids. So what ends up happening is our body gets this signal that we need more. So.