This content was created by McCall McPherson. This content was uploaded by McCall McPherson. This is a YouTube video titled "Who are good candidates for weight loss medications like Ozempic?" (created 2024-01-23T17:21:29Z) featuring McCall McPherson presenting a monologue about candidacy for GLP-1/Tirzepatide class medications (Wegovy, Mounjaro/Manjaro, Ozempic, semaglutide, tirzepatide). McCall argues these drugs are valuable not only for people with obesity or type 2 diabetes but especially for women with thyroid and hormonal dysfunction whose metabolism remains impaired despite normal lab values and healthy behaviors. She explains the drugs can reset baseline weight and promote metabolic healing — improving insulin sensitivity, lowering hemoglobin A1c, and improving leptin — so patients can eventually discontinue medication and maintain weight with normal effort. She states the Modern Thyroid Clinic targets before stopping therapy: A1c close to or below 5.0 and fasting insulin below 10 (ideally near 6), and emphasizes that underlying thyroid issues must be addressed first.
Questions this video answers
Close to or less than 5.0.
Below 10 μU/mL, ideally close to 6 μU/mL.
Chapters
Who is the perfect candidate for weight loss medications like wegovy, Manjaro, Ozempic, Semaglutide, Tirzepatide, and we're going controversial. Okay? So I know people think that these meds are only for obese people, people with type 2 diabetes, chronically obese people, that kind of thing. I disagree. So. So obviously in my practice, I'm dealing with women who have thyroid and hormonal issues, right? That's what modern thyroid clinic is completely centered around. These women, even when their thyroid function is perfect, y'. All. And my definition of perfect is not. Yeah, yeah, yeah, I know you have all these symptoms, but your thyroid labs are fine. No, my definition of perfect is these people do not have thyroid symptoms anymore. It takes a long time after that for these women to repair their metabolism. Thyroid issues create metabolic damage, you lose your metabolic potency. And what leads. What happens with that is, hey, you can actually eat perfect or reasonably perfect and exercise and have a fantastic lifestyle and not lose weight. The answer for these women is not eat less, exercise more. No, no, no. Okay, that doesn't work. And so in my opinion, whether these women have 15 pounds or 75 pounds to lose, this class of weight loss medication is amazing for this particular subset of person. Why? Because A, yes, it allows them to reset their baseline weight. It allows them to lose weight and return to what their optimal weight is. But B, B is where it gets good. While these women are losing weight, there is metabolic healing and repair taking place. Their insulin is resensitizing their blood sugar. Their hemoglobin A1C is dropping. And I'll give you the numbers at the end of where I like these women to be optimally, from a metabolic standpoint, their leptin is improving so that by the time they reset their weight, already we fix their thyroid problem. Right. By the time their weight is resetting, their metabolism is also healed or almost healed. And what does that mean? It means they can come off of these medications and maintain their weight with normal people effort without basically having an eating disorder to maintain their weight. Right? Because honestly, that's what a lot of these women are doing. They are over restricting. They're having to over restrict to maintain their weight. They're having to eat rigidly, perfectly all the time to not gain weight. So the goal is, hey, you come off of these meds and you're able to maintain that weight successfully with normal people, reasonable effort. Okay? So I told you I would give you my ranges. So by the time people at mtc, at modern thyroid clinic come off of our weight loss program. I want their hemoglobin A1C to be close or less than 5.0, and I want their insulin to be below 10, but really I want it ideally close to 6, and that's fasting insulin. So those are the markers that I look for that say, hey, look, these people are in metabolically a good place to come off successfully. And obviously you have to have your thyroid problem fixed, addressed and perfected for this to work. Otherwise, you're just going to recreate that loss of metabolic potency.
