Never get Alzheimer’s Disease: The NAD Story
In this presentation, the speaker highlights a pivotal finding that the essential cellular energy cofactor NAD+ is markedly reduced in the brains of individuals with Alzheimer’s disease compared to healthy controls. Because NAD+ underpins major metabolic pathways—including glucose metabolism, fatty acid oxidation, and mitochondrial respiration—its depletion compromises neuronal energy production. The speaker then reviews preclinical animal studies and supporting human data showing that restoring NAD+ levels can not only slow but sometimes reverse core Alzheimer’s pathology: memory performance improves, neuronal function recovers, and neuroinflammation diminishes. Finally, the talk emphasizes that NAD+ can be naturally elevated through lifestyle interventions such as regular exercise and intermittent fasting, suggesting a potentially accessible strategy for disease mitigation.
