1:16

In this personal science video, the creator recounts a month‑long experiment in which he ate roughly 1,000 sardines, noting an unexpected side effect: he no longer felt cold during New England winter blizzards. To explain the phenomenon, he consulted scientific literature and experts, discovering that the massive intake of omega‑3 fatty acids can be metabolized into the hormone 12‑HEPE. This hormone activates brown‑fat thermogenesis, increasing energy expenditure and heat production, which accounts for his cold‑resistance. Intriguingly, the receptor for 12‑HEPE is an olfactory (smell) receptor that is expressed in multiple tissues—including liver, brain, and brown fat—linking the characteristic sardine odor to the metabolic pathway. The video ends by questioning whether the metabolic “superpower” is worth the trade‑off of constantly smelling like fish.

Chapters

More from Nick

1:04
youtube.com

What People Get Wrong About Lp(a)

2d ago
20:44
youtube.com

The Focus Trick I Wish I Knew Sooner

4d ago
0:53
youtube.com

Healthy Things That Are Really Unhealthy

6d ago
0:57
youtube.com

What Happens When You Eat Blueberries vs Syrup?

1w ago
1:05
youtube.com

The Weirdest GLP-1 Weight-Loss Paradox

1w ago
23:17
youtube.com

How to Lose Fat AND Build Muscle

1w ago
0:59
youtube.com

Fermented Foods vs. Fiber—Who Wins?

2w ago
1:15
youtube.com

Do You Feel Like You Have ADHD?

2w ago
15:47
youtube.com

What I Wish I Knew About Caffeine Sooner

2w ago
1:01
youtube.com

Don’t Eat Bananas Until You Know This.

2w ago
0:53
youtube.com

The Next Ozempic Could Be a Sleep Drug

3w ago
See all content