Jaiwant Rangi, MD, FACEEndocrinologist | Founder, Lower The Dose® | Speaker

Mastering Metabolic Health Through Inflammation and Nutrient Optimization

3 Jun 2026 · 1 min

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Dr. Jaiwant Rangi explains how chronic inflammation damages insulin signaling and glucose metabolism. Muscle is where your body disposes most glucose, so losing muscle worsens metabolic dysfunction. Vitamin D and B12 deficiencies amplify insulin resistance, especially in people taking metformin.

Chapters

What is contributing to the inflammation? If we can reverse that, that can help us improve insulin signaling, glucose metabolism. And in some cases, like I mentioned, muscle is your biggest glucose disposal organ. And if you have muscle loss or if you have poor muscle mass to begin with, in some cases we see nutrient deficiencies. For example, if you have vitamin D deficiency, your insulin signaling does not work well. You have more insulin resistance. Vitamin B12 deficiency, we see that a lot in people on metformin.