Jaiwant Rangi, MD, FACEEndocrinologist | Founder, Lower The Dose® | Speaker

Metabolic Chaos: Cortisol, Glucose, and the Liver

18 May 2026 · 1 min

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Dr. Jaiwant Rangi explains how chronic cortisol exposure causes the liver to continuously release glucose into the bloodstream. Combined with a sedentary lifestyle, this excess sugar stays in the blood, creating a persistent drip of glucose and insulin that drives insulin resistance and metabolic dysfunction.

Chapters

There's a process called gluconeogenesis where our liver makes sugar, and also cortisol signals the liver to release the stored glucose for the body to heal as a fuel or fight or flight. So under normal circumstances, our liver should be able to store that glucose and release it only when needed. But you're constantly giving that cortisol to the liver, then you're going to constantly put out the sugar. So that is one main mechanism how it works. You know, when we're sitting on our desk all the time and the sugar isn't used, it just lingers in the blood. It just stays there, and over time, this constant drip of glucose and insulin resistance creates some metabolic chaos in our body.