Jaiwant Rangi, MD, FACEEndocrinologist | Founder, Lower The Dose® | Speaker

The Heavy Cost of Quick Weight Loss: Why Muscle Mass Matters

6 Aug 2026 · 1 min

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0:31

Dr. Jaiwant Rangi explains that GLP-1 drugs like Ozempic and Wegovy cause patients to lose about 10% of their muscle mass alongside fat. He's seen people drop 30 to 100 pounds on these medications. Exercise during weight loss is critical to preserve muscle.

We get so many people asking for Ozempic and Wegovy and Zepbound and Mounjaro and that class of medication, GLP-1 agonists. People need to understand you lose 10% of muscle mass, 10%. So I have many patients I've helped lose 50 pounds, 100 pounds, 30 pounds, whatever it is. But I always tell them, if you're losing almost 10% of muscle mass, you have to see where you started with. You cannot afford to lose muscle. So you really need to continue to exercise to build up that muscle so you don't lose it.

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