mthfr e-book
PDF · 26 Sept 2025
A practitioner-focused guide explaining the MTHFR gene, common variants (C677T/rs1801133 and A1298C/rs1801131), their effects on MTHFR enzyme activity and methylation, health implications (cardiovascular, reproductive, mental health, detoxification, energy, thyroid), testing and interpretation, communication strategies in nutrigenomics, dietary sources of folate, and evidence-informed supplement and monitoring recommendations (including 5‑MTHF, B12, B6, B2). The document includes tables summarising genotype-to-activity estimates and suggested interventions.
Questions this document answers
400 mcg per day.
600 mcg per day during pregnancy.
500 mcg per day during breastfeeding.
1,000 mcg per day for adults.
rs1801133.