Fast This Way: World-Renowned Biohacker’s Fasting Strategies with Dave Asprey

19 Dec 2022 · 49 min
Episode

19 Dec 2022 · 49 min

0:00

In this episode of Flow Research Collective Radio, host Ryan Dorris and bestselling author Steven Kotler interview biohacker Dave Asprey about his new book Fast This Way. Asprey explains why skipping breakfast and extending the nightly fast is the single most powerful dietary lever for health and performance. He breaks down practical “fasting hacks” that make fasting painless: drinking black coffee (which doubles ketone production and suppresses ghrelin), Bulletproof Coffee with the specific Brain Octane MCT oil (which further raises ketones), and adding a small amount of prebiotic soluble fiber to feed gut microbes that produce anti‑inflammatory short‑chain fatty acids. He discusses the physiology of fasting—how ketosis, insulin, ghrelin, CCK, mTOR, and cortisol interact, and how circadian timing (eating only while the sun is up) amplifies benefits. Asprey outlines a spectrum of fasts, from the minimal 12‑hour fast to 24‑hour OMAD, multi‑day water‑only fasts, protein‑fasts, fasting‑mimicking diets, and even non‑food fasts such as dopamine, social‑media, and “hate” fasts. He warns about over‑fasting, describing gender‑specific warning signs (sleep disruption, hair thinning, menstrual changes) and advises adjusting fast length based on daily stress, sleep quality, and workout intensity. The conversation also touches on spiritual fasting, historical practices like hair‑shirt fasting, and the role of water‑lipid interactions (citing Dr. Gerald Pollack’s fourth‑phase water research) in enhancing ketone utilization. Throughout, Asprey emphasizes a flexible, data‑driven approach—using tools like continuous glucose monitors, HRV rings, and personal observation—to tailor fasting protocols for optimal flow and peak performance. The episode closes with a “research genie” question, where Asprey calls for deeper scientific study of food anti‑nutrients and personalized nutrition.

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